7119-95-1, A common heterocyclic compound, 7119-95-1, name is 1-Nitropyrazole, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-Nitro-lJH-pyrazoIe=N; [547] [Ref: Huettel, R. and Buechele, F., Chem. Ber. 1955, 88, 1586-1590] 1-Nitro-l/Z’-pyrazole (2.2g, 0.019 mol) was dissolved in sulfuric acid (lOmL) at-10¡ãC, and theresulting mixture was slowly warmed to rt overnight. The solution was added to ice (lOOg)dropwise, and the resulting white solid was collected by filtration and washed with water.The aqueous phase was extracted with EtOAc (3x30mL), the combined organic phases werewashed with brine (2x30mL), and dried over anhydrous sodium sulfate. Evaporation underreduced pressure provided an off-white solid, which was combined with the first solid anddried in vacua to provide the title compound. LC-MS (ES, Pos.): 1 14 [MH+]. ‘H NMR(DMSO-d6, 400 MHz): 8 = 8.27 (s, 1H), 8.90 (s, 1H), 13.96 (br s, 1H).
The synthetic route of 7119-95-1 has been constantly updated, and we look forward to future research findings.