He, Yuanjun; Duckett, Derek; Chen, Weimin; Ling, Yuan Yuan; Cameron, Michael D.; Lin, Li; Ruiz, Claudia H.; LoGrasso, Philip V.; Kamenecka, Theodore M.; Koenig, Marcel published the artcile< Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors>, Computed Properties of 936250-20-3, the main research area is pyridylisoxazole preparation JNK inhibitor SAR selectivity p38; Isoxazole; JNK; Kinase; c-Jun.
The design and synthesis of isoxazole I is described, a potent JNK inhibitor with two fold selectivity over p38. Optimization of this scaffold led to compounds II and III which showed greatly improved selectivity over p38 by maintaining the JNK3 potency of compound I. Extensive SAR studies will be described as well as preliminary in vivo data of the two lead compounds
Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 936250-20-3 belongs to class pyrazoles-derivatives, and the molecular formula is C10H17BN2O2, Computed Properties of 936250-20-3.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics