The chemical industry reduces the impact on the environment during synthesis 2075-46-9, name is 4-Nitro-1H-pyrazole, I believe this compound will play a more active role in future production and life. 2075-46-9
Into a 250 mL round-bottom flask, was placed a solution of compound 28.1 (5 g, 44.22 mmol, 1.00 equiv) in CH3CN (100 mL), 2-bromoethan-1- ol (11 g, 88.02 mmol, 2.00 equiv) and potassium carbonate (18.5 g, 133.85 mmol, 3.00 equiv). The resulting solution was stirred overnight at 95C in an oil bath. The reaction was then quenched by the addition of water and extracted with 3 x 100 mL of ethyl acetate. Organic layers were combined and concentrated under vacuum. The product crude was purified using flash column chromatography to furnish 3.5 g (50%) of intermediate 28.2 as yellow oil.
The chemical industry reduces the impact on the environment during synthesis 2075-46-9. I believe this compound will play a more active role in future production and life.