Zhou, You; Wang, Li-Sheng; Lei, Shuang-Gui; Gao, Yun-Xiang; Ma, Jin-Tian; Yu, Zhi-Cheng; Wu, Yan-Dong; Wu, An-Xin published the artcile< I2-Promoted site-selective C-C bond cleavage of aryl methyl ketones as C1 synthons for constructing 5-acyl-1H-pyrazolo[3,4-b]pyridines>, Recommanded Product: 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine, the main research area is aryl methyl ketone aminopyrazole enaminone iodine cleavage cyclization; pyrazolopyridine regioselective preparation.
A novel iodine promoted [1 + 3 + 2] cleavage cyclization reaction for the synthesis of 1H-pyrazolo[3,4-b]pyridines from aryl Me ketones, 5-aminopyrazoles and enaminones was established. This transition metal-free catalysis method has simple reaction conditions and good substrate compatibility, and was demonstrated in the transformation of alkyl and natural mol.-derived enaminones. Mechanistic studies showed that two cyclization pathways affording different key intermediates were involved, but affording the same target product after site-selective cleavage of the unstrained C-C bond of the acyl group.
Organic Chemistry Frontiers published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, Recommanded Product: 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics