Broom, N. J. P.; Elder, J. S.; Hannan, P. C. T.; Pons, J. E.; O’Hanlon, P. J.; Walker, G.; Wilson, J.; Woodall, P. published the artcile< The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocycle-substituted oxazole derivatives>, Electric Literature of 17827-61-1, the main research area is pseudomonic acid heterocycle oxazole derivative preparation; bactericide heterocycle oxazole derivative preparation.
Semisynthetic analogs of pseudomonic acid A were prepd containing a heterocycle-substituted oxazole. Derivatives in which the heterocycle was thiophene, furan, pyridine, or isoxazole showed good antibacterial potency and were further evaluated in vivo. Both pharmacokinetic parameters and oral activity against an exptl. i.p. sepsis were superior to results obtained from previously described pseudomonic acid A derivatives
Journal of Antibiotics published new progress about 17827-61-1. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Electric Literature of 17827-61-1.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics