Hilpert, Lukas J.; Sieger, Simon V.; Haydl, Alexander M.; Breit, Bernhard published the artcile< Palladium- and Rhodium-Catalyzed Dynamic Kinetic Resolution of Racemic Internal Allenes Towards Chiral Pyrazoles>, Synthetic Route of 13808-65-6, the main research area is pyrazole allene palladium rhodium catalyst chemoselective regioselective enantioselective hydroamination; alkenylpyrazole preparation; asymmetric catalysis; dynamic kinetic resolution; internal allenes; palladium; rhodium.
A complementing Pd- and Rh-catalyzed dynamic kinetic resolution (DKR) of racemic allenes leading to N-allylated pyrazoles was described. Such compounds are of enormous interest in medicinal chem. as certified drugs and potential drug candidates. The new methods feature high chemo-, regio- and enantioselectivities aside from displaying a broad substrate scope and functional group compatibility. A mechanistic rational accounting for allene racemization and trans-alkene selectivity was discussed.
Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 13808-65-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Synthetic Route of 13808-65-6.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics