Morgentin, Remy; Barlaam, Bernard; Foote, Kevin; Hassall, Lorraine; Hawkins, Janet; Jones, Clifford D.; Le Griffon, Antoine; Peru, Aurelien; Ple, Patrick published the artcile< Two-Directional Approach for the Rapid Synthesis of 2,4-Bis-Aminoaryl Pyridine Derivatives>, Electric Literature of 118430-74-3, the main research area is aminoarylpyridine preparation coupling palladium; pyridine aminoaryl preparation coupling palladium; Buchwald Hartwig regioselective nucleophilic substitution bisaminoarylpyridine preparation.
We have developed two different approaches in parallel to rapidly access 2,4-bis(aminoaryl)pyridine compounds, e.g., I, from a common starting material. The C-4/C-2 approach uses palladium-mediated coupling reactions to sequentially functionalize C-4 and then C-2. An alternative C-2/C-4 route uses a regioselective SNAr reaction to first substitute at C-2 then subsequently at C-4 by a palladium-mediated reaction. Both approaches have been used successfully to provide a range of 2,4-bis(aminoaryl)pyridine compounds
Synthetic Communications published new progress about Buchwald-Hartwig reaction. 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, Electric Literature of 118430-74-3.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics