Elie, Jonathan; Fruit, Corinne; Besson, Thierry published the artcile< Microwave-assisted sequential one-pot synthesis of 8-substituted pyrazolo[1,5-a][1,3,5]triazines>, Application of C6H5ClN4S, the main research area is aminopyrazole ethoxycarbonyl isothiocyanate microwave assisted heterocyclization; methylsulfanyl pyrazolotriazinone preparation; 5-aza-9-deazapurines; microwave-assisted chemistry; one-pot synthesis; pyrazolo[1,5-a][1,3,5]triazines.
A convenient sequential one-pot approach for the synthesis of an array of 14 pyrazolo[1,5-a][1,3,5]triazines, I [R = H, Br, CN, etc] substituted in C8 by halogen (Br), various functions (CN and CO2Et) and alkyl or (het)aryl groups was reported. This study confirmed the interest of combining the efficient heating obtained under dielec. microwave heating and the achievement of sequential one-pot reactions, avoiding the tedious work-up and purification of intermediate compounds, achieving sustainable synthesis processes. Considering usual conventional methods, this microwave protocol was featured by advantages in terms of yields, reaction times, and convenient gram scale synthesis.
Molecules published new progress about Fused heterocyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 54346-19-9 belongs to class pyrazoles-derivatives, and the molecular formula is C6H5ClN4S, Application of C6H5ClN4S.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics