In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1453-58-3, name is 3-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 1453-58-3
Potassium t-butoxide (3.9 g, 0.33 mmol) was dissolved in DMSO (25 mL). Tothis solution was added 3-methyl pyrazole (2.7 g, 0.33 mmol) and the reactionwas heated at 50 C for 30 min. 1-Bromo-4-chloro-2-fluorobenzene (4.6 g, 0.22mmol) was then added and the reaction was stirred at 50 C for 16 h. The reaction was cooled to RT and extractedwith water and ethyl acetate, washed with brine, and dried over Na2SO4,filtered and concentrated in vacuo. Purification by normal phase silica gelcolumn chromatography (ethyl acetate/heptane) provided 1-(2-bromo-5-chlorophenyl)-3-methyl-1H-pyrazoleand 1-(2-bromo-5-chlorophenyl)-5-methyl-1H-pyrazole as a 4:1 mixture (41 & 42) that was used in the nextstep directly (5.4 g).
The synthetic route of 1453-58-3 has been constantly updated, and we look forward to future research findings.