《Synthesis of halosulfuron-methyl via selective chlorination at the 3- and/or 5-position of pyrazole-4-carboxylates》 was written by Morimoto, Katsushi; Sato, Toshiaki; Yamamoto, Susumu; Takeuchi, Hiroshi. Reference of Methyl 1-methyl-1H-pyrazole-4-carboxylate And the article was included in Journal of Heterocyclic Chemistry on April 30 ,1997. The article conveys some information:
Heating Me pyrazole-4-carboxylates I (X = Cl, Y = H; X = H, Y = Cl; X = Y = H) with N-chlorosuccinimide without a solvent gave I (X = Y = Cl) in good yields. Reaction of I (X = Y = H) with NaSH led to nucleophilic substitution on the 5-position regioselectively to afford I (X = Cl, Y = SH); subsequent oxidative chlorination and amination gave I (X = Cl, Y = SO2NH2). Finally, the reaction of I (X = Cl, Y = SO2NH2) with Ph 4,6-dimethoxy-2-pyrimidinyl carbamate provided halosulfuron-Me (II), a promising herbicide for cornfields. In the experimental materials used by the author, we found Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2Reference of Methyl 1-methyl-1H-pyrazole-4-carboxylate)
Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Reference of Methyl 1-methyl-1H-pyrazole-4-carboxylate
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics