The author of 《Inhibition of fatty acid release by pyrazole derivatives》 were Bizzi, Adalgisa. And the article was published in Progress in Biochemical Pharmacology in 1968. Recommanded Product: (3-methyl-1H-pyrazol-5-yl)methanol The author mentioned the following in the article:
In rats, 3,5-dimethylpyrazole (I) is quiet active in decreasing free fatty acid (FFA) and glycerol in adipose tissue as well as in plasma with doses as low as 50 μg/kg, i.p. In plasma after 2 hr, I and 5-carboxyl-3-methylpyrazole (II) appear more active than 3-methylpyrazole. When tested in vitro on the release of FFA from adipose tissue, II appeared to be the most active. The 3 compounds when given orally in doses of 0.75-30 mg/kg also produce up to a 50% decrease in plasma triglycerides. This effect is proportional to the dose used. The experimental part of the paper was very detailed, including the reaction process of (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7Recommanded Product: (3-methyl-1H-pyrazol-5-yl)methanol)
(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Recommanded Product: (3-methyl-1H-pyrazol-5-yl)methanol
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics