Name: Methyl 1H-pyrazole-3-carboxylateIn 2021 ,《Route Design to Manufacture: Synthesis of the Heterocyclic Fragment of AZD5718 Using a Non-cryogenic Lithiation-Alkoxycarbonylation Reaction》 was published in Organic Process Research & Development. The article was written by Burns, Matthew; Perkins, Dave; Chan, Lai C.; Pilling, Michael J.; Jawor-Baczynska, Anna; Mullen, Alexander K.; Steven, Alan; Wimsey, Chris; Elmekawy, Ahmed; Lamacraft, Alex; Dobson, Benjamin C.; McMillan, Angus E.; Hose, David R. J.; Inglesby, Phillip A.; Raw, Steven A.; Jones, Martin F.. The article contains the following contents:
Route design and process development of the small nitrogen heterocycle I, a constituent of AZD5718 (II), is described. The novel synthetic sequence to I involves a desymmetrizing alkylation of 4-nitropyrazole, a non-cryogenic lithiation-alkoxycarbonylation, and a global reduction-cyclization. This new synthetic route was implemented in the manufacture of I and was able to deliver over 1000 kg of product with a yield of 77% over the three stages. In the experiment, the researchers used many compounds, for example, Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Name: Methyl 1H-pyrazole-3-carboxylate)
Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Name: Methyl 1H-pyrazole-3-carboxylate
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics