Vasilevskii, S. F.; Shvartsberg, M. S. published the artcile< Oxidative iodination of substituted N-methylpyrozoles>, Computed Properties of 17827-61-1, the main research area is oxidation iodination methylpyrazole; pyrazole methyl oxidation iodination.
1-Methylpyrazole was iodinated in position 4 with iodine in aqueous KI with a low yield: introduction of an electron donor substituent in position 3 or 5 increased the reactivity of the heterocycle. Iodination of 5-amino-1,3-dimethylpyrazole gave 80% 4-iodide, but its N-acetyl derivative did not react. N-Methylpyrazole-4-carboxylic acids and -4-aldehydes underwent iodination under the same conditions and gave the 4-iodo or polyiodo derivative The presence of moderately strong electro acceptor substituents, e.g., iodo, or CO2Me, in the ring in the 4 position did not exclude the possibility of oxidative iodination at other positions of the ring. Strong electron acceptor groups, e.g., NO2, retard the reaction.
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about Iodination. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Computed Properties of 17827-61-1.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics