Xun, Zhan; Feng, Xian; Wang, Jianjun; Shi, Daqing; Huang, Zhibin published the artcile< Multicomponent Strategy for the Preparation of Pyrrolo[1,2-a]pyrimidine Derivatives under Catalyst-Free and Microwave Irradiation Conditions>, Name: 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine, the main research area is pyrrolopyrimidine preparation microwave irradiation regioselective; aminopyrazole acetylenedicarboxylate malononitrile multicomponent reaction.
A simple and efficient one-pot procedure has been developed for the construction of pyrrolo[1,2-a]pyrimidines I (R = Me, Et; R1 = H, CH3, C6H5; R2 = Me, Ph, cyclopropyl) via the three-component domino reaction of 5-aminopyrazoles II, acetylenedicarboxylates RCO2CCCO2R and malononitrile under catalyst-free, microwave irradiation conditions. The key step in this transformation is the N-N bond cleavage reaction of the II substrate, which has been reported in this context for the first time in this study. The advantages of this protocol include readily available starting materials, short reaction times and good regioselectivity.
Chinese Journal of Chemistry published new progress about Microwave irradiation. 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, Name: 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics