26621-44-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26621-44-3, name is 3-Nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
MC-163-1 (2 g, 17.68 mmol, 1.0 eq), p-toluenesulfonic acid (336 mg, 1.668 mmol, 0.1 eq) was dissolved in 40 mL of tetrahydrofuran.Then DHP (1.6 g, 19.448 mmol, 1.1 eq) was added. The reaction was carried out at room temperature for 16 hours.The reaction solution was added with water 25 mL, and ethyl acetate 35 mL was extracted three times.The organic phase was washed with saturated brine and dried over anhydrous sodiumPurified by column (petroleum ether: ethyl acetate 20:1 to 5:1)Get oil MC-158-1(3.5g, 99%).
The synthetic route of 3-Nitro-1H-pyrazole has been constantly updated, and we look forward to future research findings.