2075-46-9, These common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dimethyl sulphate (3.33g, 26.4mmol) was slowly added to a stirred solution of 2b (1.Og, 8.85mmol) in IN NaOH (1OmL) that had been warmed to 3O0C. After being stirred at r.t. for 3.5h, the reaction mixture was extracted with ethyl acetate (10mLx4), combined the organic phase, washed with brine (2OmL), dried over MgSO4, filtered and concentrated. The residue was triturated with petrol and filtered to give 3a (0.98g, 87%) as a white solid.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2075-46-9.