Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3-one nucleosides was written by Abdou, Ibrahim M.;Saleh, Ayman M.;Zohdi, Hussein F.. And the article was included in Molecules in 2004.Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one This article mentions the following:
2,4-Dihydropyrazole glucosides were prepared and tested for their antitumor activity. The structures of these compounds were established by 1H and 13C- NMR spectroscopy. The para-fluoro glucoside shows an in vitro IC50 value of 16.4 娓璏 against proliferation of the human promyelotic leukemia (HL60) cell line. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one).
3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics