Day: February 13, 2023

Nitropyrazoles. 3. Synthesis of C-(diformylmethyl)nitropyrazoles was written by Dalinger, I. L.;Shkineva, T. K.;Shevelev, S. A.;Krat, V.;Arnold, Z.. And the article was included in Izvestiya Akademii Nauk, Seriya Khimicheskaya in 1993.Category: pyrazoles-derivatives This article mentions the following:

A double Vilsmeier formylation of a C-Me group in pyrazole derivatives occurs when a nitro group is adjacent to the Me group. Thus, dimethylnitropyrazole I was treated with DMF and POCl₃ to give diperchlorate II, which was hydrolyzed to bis(diformylmethyl) derivative III. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Category: pyrazoles-derivatives).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reactions of N-aminopyrazoles with halogenating reagents and synthesis of 1,2,3-triazines was written by Osawa, Akio;Kaiho, Terumitsu;Ito, Takashi;Okada, Mamiko;Kawabata, Chikako;Yamaguchi, Kentaro;Igeta, Hiroshi. And the article was included in Chemical & Pharmaceutical Bulletin in 1988.Synthetic Route of C5H7ClN2 This article mentions the following:

Reactions of N-aminopyrazoles with halogenating reagents (Cl₂, Br₂, I₂, BrCl, ICl, IBr, N-chlorosuccinimide, and N-bromosuccinimide) were examined Some of these reagents preferentially leas to oxidation of the amino group to give the corresponding 1,2,3-triazines as major products, while others mainly gave either or both of 1-amino-4-halopyrazoles and 5-halo-1,2,3-triazines as the result of halogenation of the 4-position of the pyrazole ring prior to the oxidation of the amino group. In some cases, the oxidation of the amino group and the halogenation of the pyrazole ring proceeded concurrently to form not only the unhalogenated triazines but also the 1-amino-4-halopyrazines and the 5-halotriazines. Various reagents and reaction conditions were explored to utilize the reaction for the synthesis of halogenated and unhalogenated 1,2,3-triazines. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Synthetic Route of C5H7ClN2).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Synthetic Route of C5H7ClN2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

A simple and environmentally benign nitration of pyrazoles by impregnated bismuth nitrate was written by Ravi, P.;Gore, Girish M.;Tewari, Surya P.;Sikder, Arun K.. And the article was included in Journal of Heterocyclic Chemistry in 2013.HPLC of Formula: 54210-32-1 This article mentions the following:

A facile, rapid, and environmentally friendly synthesis of nitropyrazoles in good yields was reported using silica-bismuth nitrate and silica-sulfuric acid-bismuth nitrate at room temperature The relatively non-toxic nature, ease of handling, easy availability, and low cost make the present procedure attractive for the nitration of a wide variety of diazoles in drug and pharmaceutical industries. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1HPLC of Formula: 54210-32-1).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. HPLC of Formula: 54210-32-1

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Design, synthesis and herbicidal activities of novel 4-(1H-pyrazol-1-yl)-6-(alkynyloxy)-pyrimidine derivatives as potential pigment biosynthesis inhibitors was written by Ma, Hong-Ju;Zhang, Jian-Hua;Xia, Xiang-Dong;Xu, Meng-Han;Ning, Jun;Li, Jian-Hong. And the article was included in Pest Management Science in 2014.COA of Formula: C4H5N3O2 This article mentions the following:

BACKGROUND With the objective of finding novel valuable herbicidal candidates, a series of novel 4-(1H-pyrazol-1-yl)-6-(alkynyloxy)-pyrimidine derivatives were synthesized and their herbicide activities were evaluated in vivo. RESULTS The results showed that many target compounds expressed bleaching activities. Among these, compound 5 h showed the best bleaching activity to gramineous weeds, being able to produce the highest inhibition of chlorophyll level in seedlings of Pennisetum alopecuroides L. (IC₅₀ = 3.48 mg L-1). Moreover, compound 5 h expressed good selective toxicity between gramineous P. alopecuroides L. and broadleaf plant Brassica campestris L. CONCLUSIONS The present work demonstrates that pyrimidine derivatives containing pyrazole can be used as potential lead compounds for developing novel pigment biosynthesis inhibitors. 婕?2013 Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4COA of Formula: C4H5N3O2).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 鎺矯).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.COA of Formula: C4H5N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Dipole moment and tautomeric form of 3(5)-nitropyrazole in dioxane solution was written by Aksamentova, T. N.;Krivoruchka, I. G.;Elokhina, V. N.;Vokin, A. I.;Lopyrev, V. A.;Turchaninov, V. K.. And the article was included in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) in 1999.Formula: C4H5N3O2 This article mentions the following:

The dipole moments of 3(5)-nitropyrazole, its Me-substituted derivatives, and H-complexes with dioxane were measured exptl. and estimated by ab initio calculations (6-31G^* basis set). Comparison of the exptl. and calculated dipole moments suggests a shift of the tautomeric equilibrium toward the 3-nitro isomer. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Formula: C4H5N3O2).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Formula: C4H5N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of 1H-pyrazolo[3,4-b]pyridines was written by Haeufel, Jochen;Breitmaier, Eberhard. And the article was included in Angewandte Chemie in 1973.Recommanded Product: 3528-58-3 This article mentions the following:

The pyrazolopyridines [I; R = Me, Pr, Bu; R1 = H; or RR1 = (CH2)n, n = 4,5,6, or 10; R2 = Me, Et, Ph; R3 = H, Me] were prepared in 51-87% yield by reaction of the pyrazoles II with R1COCR:CHR4 (R4 = OH, alkoxy, NH2) in HOAc and subsequent precipitation with H2O, or addition of NaOH and extraction with Et2O, or distillation of HOAc. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Recommanded Product: 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Recommanded Product: 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis and biological activities of 3-substituted-6- pyrazolyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles was written by An, Yue;Yao, Mingxing;Zhou, Xiaoxia;Liu, Mingyang. And the article was included in Yingyong Huaxue in 2014.Synthetic Route of C11H10N2O2 This article mentions the following:

The three kinds of 1-methyl-5-substituted-pyrazole-3-carboxylic acid were obtained by 5-substituted-1H-pyrazole-3-Et formate based on methylation and hydrolysis of the ester. Then the six kinds of 3-substituted-4-amino-5-mercapto-1,2,4-triazole were obtained using the substituted carboxylic acid by a series of reaction. Finally, eighteen novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles compounds were synthesized by phosphorus chloride treatment of the above two obtained intermediate. The structures of all new compounds were characterized by IR, ¹H NMR, ¹³C NMR and elemental analyses. The preliminary test shows that all the compounds display plant growth regulator activity and antibacterial activity. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8Synthetic Route of C11H10N2O2).

1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 鎺矯).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Synthetic Route of C11H10N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electronic effects in the catalytic hydrosilylation with in-situ generated iron(II)-catalysts was written by Muller, Keven;Schubert, Anett;Jozak, Thomas;Ahrens-Botzong, Annegret;Schuenemann, Volker;Thiel, Werner R.. And the article was included in ChemCatChem in 2011.Electric Literature of C9H9N3 This article mentions the following:

In combination with different aromatic N,N-donors, iron acetate and octanoate are suitable catalyst precursors for the hydrosilylation of carbonyl compounds Iron octanoate can be used to perform this catalytic transformation in cheap and non-toxic petrol ether or heptane as the solvent and with versatile polymethylhydrosiloxane (PMHS) as the silane source. Investigation of the performed catalyst (iron octanoate + N,N-ligand + PMHS) by using Moessbauer spectroscopy suggests that the active species is a high-spin iron(II) system. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Electric Literature of C9H9N3).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Electric Literature of C9H9N3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Transition metal azolates from metallocenes. Part 3: polymeric manganese(II) and nickel(II) pyrazolates; synthesis, characterization, and magnetochemistry was written by Storr, Alan;Summers, David A.;Thompson, Robert C.. And the article was included in Canadian Journal of Chemistry in 1998.Recommanded Product: 15953-73-8 This article mentions the following:

Direct reactions of nickelocene and manganocene with molten pyrazoles in an inert atm. or under vacuum gave the following metal pyrazolate compounds: [Ni(4-Xpz)₂]_x (X = H, Cl and pz = pyrazolate); [M(4-Xdmpz)₂]_x (X = Cl, Br and pzH = pyrazole). On the bases of indirect evidence all compounds are considered to have extended chain structures with metal ions linked in chains by double bridging pyrazolates. The two [Ni(4-Xpz)₂]_x compounds are diamagnetic compounds while all others are paramagnetic and reveal antiferromagnetic coupling between neighboring metal ions. Analyses of the magnetic data (Hamiltonian H = -2J 鍗?S_i-S_j) yields values of the exchange coupling compounds and -0.41 cm^-1 for the [Mn(4-Xpz)₂(4-XpzH)]_x compounds In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Recommanded Product: 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor閳ユ徆onor motifs, whether as a monocyclic ring or as a fused indazole ring. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Recommanded Product: 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Nitro azines. 20. Simple syntheses of pyrazolo-condensed nitropyridines from aliphatic nitro synthons and aminopyrazoles was written by Rusinov, V. L.;Petrova, A. Yu.;Chupakhin, O. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1992.Recommanded Product: 55361-49-4 This article mentions the following:

Treating aminopyrazoles I (R, R¹ = H, Me, Ph) with the Na salt of O₂NCH(CHO)₂ in water gave 65-75% pyrazolopyridines II (R = H, R¹ = Ph, Me, H; R = Me, R¹ = Me, H; R = Ph, R¹ = H); and in AcOH 70-90% II (R = H, Me, Ph, R¹ = Ph; R = H, Me, R¹ = Me) were obtained. Addnl. obtained were pyrazolopyridines III (R = H, Me, R¹ = Ph). In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4Recommanded Product: 55361-49-4).

1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 鎺矯).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 55361-49-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics