Day: February 9, 2023

Michael addition of α-nitroacetate to α, β-unsaturated pyrazolamide catalyzed by triethylamine was written by Liu, Yingying;He, Qian;Chen, Feng;Li, Xuefeng. And the article was included in Shandong Huagong in 2018.Recommanded Product: 15953-73-8 This article mentions the following:

An efficient Michael addition of α-nitroacetate to α, β-unsaturated pyrazolamide was developed in the presence of triethylamine. Synthetically useful yields (50% ∼ 88%) have been achieved with various α, β-unsaturated pyrazolamides. The structures of adducts have been clearly confirmed by ¹H-NMR, ¹³C-NMR and HRMS anal. Adducts resulting from this protocol are useful synthetic intermediates for further synthetic modification. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Recommanded Product: 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

A simple and catalyst free one pot access to the pyrazolone fused 2,8-dioxabicyclo[3.3.1]nonanes was written by Bingi, Chiranjeevi;Emmadi, Narender Reddy;Chennapuram, Madhu;Nanubolu, Jagadeesh Babu;Atmakur, Krishnaiah. And the article was included in RSC Advances in 2014.Reference of 401-73-0 This article mentions the following:

A series of novel aryl and heteroaryl fused 2,8-dioxabicyclo[3.3.1]nonanes I (R = 4-Cl, 4-MeO, 4-Br, etc.; R¹ = C₆H₅, 2-BrC₆H₄, 4-CNC₆H₄, etc.; R² = H, Ph) was accomplished by one pot, catalyst free reaction of 2-hydroxy chalcones with 3-trifluoromethyl substituted pyrazolones in xylene at reflux temperature The role of the trifluoromethyl functional group in formation of I was confirmed by comparative studies with 3-Me substituted pyrazolones and the outcome is presented. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0Reference of 401-73-0).

3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Reference of 401-73-0

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Novel Pyrazolo[3,4-d]pyrimidin-4-one Derivatives as Potential Antifungal Agents: Design, Synthesis, and Biological Evaluation was written by Cheng, Xiang;Wang, Wei;Wang, Yunxiao;Xia, Dongguo;Yin, Fang;Liu, Qiaoyun;Luo, Huisheng;Li, Meng;Zhang, Chengqi;Cao, Haiqun;Lv, Xianhai. And the article was included in Journal of Agricultural and Food Chemistry in 2021.Name: 5-Amino-1-(p-tolyl)-1H-pyrazole-4-carboxylic acid This article mentions the following:

Plant pathogenic fungi seriously threaten agricultural production There is an urgent need to develop novel fungicides with low toxicity and high efficiency. In this study, we designed and synthesized 44 pyrazolo[3,4-d]pyrimidin-4-one derivatives and evaluated them for their fungicidal activities. The bioassay data revealed that most of the target compounds possessed moderate to high in vitro antifungal activities. Especially compound (I) exhibited remarkable antifungal activity against Sclerotinia sclerotiorum with an EC₅₀ value of 1.25 mg/L, close to that of com. fungicide boscalid (EC₅₀ = 0.96 mg/L) and fluopyram (EC₅₀ = 1.91 mg/L). Moreover, compound g22 possessed prominent protective activity against S. sclerotiorum in vivo for 24 h (95.23%) and 48 h (93.78%), comparable to pos. control boscalid (24 h (96.63%); 48 h (93.23%)). Subsequent studies indicated that compound I may impede the growth and reproduction of S. sclerotiorum by affecting the morphol. of mycelium, destroying cell membrane integrity, and increasing cell membrane permeability. In addition, the application of compound I did not injure the growth or reproduction of Italian bees. This study revealed that compound I is expected to be developed for efficient and safe agricultural fungicides. In the experiment, the researchers used many compounds, for example, 5-Amino-1-(p-tolyl)-1H-pyrazole-4-carboxylic acid (cas: 14678-93-4Name: 5-Amino-1-(p-tolyl)-1H-pyrazole-4-carboxylic acid).

5-Amino-1-(p-tolyl)-1H-pyrazole-4-carboxylic acid (cas: 14678-93-4) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Name: 5-Amino-1-(p-tolyl)-1H-pyrazole-4-carboxylic acid

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Chemiluminescence vs. Kjeldahl determination of nitrogen in oil shale retort waters and organonitrogen compounds was written by Jones, Bonnie M.;Daughton, Christian G.. And the article was included in Analytical Chemistry in 1985.Reference of 934-48-5 This article mentions the following:

The applicability of combustion/chemiluminescent N determination to determining N in oil shale wastewaters and various representative chem. classes was demonstrated. Only azoxy compounds and those containing the pyrazole nucleus were not amenable to anal. The majority of 56 compounds tested yielded 90-110% of their theor. N content; enhanced recovery was found for N oxide salts. For 12 oil shale wastewaters, combustion/chemiluminescence gave total N values (1100-28,800 mg/L) that did not differ statistically (P > 0.10) from those obtained by the time-consuming wet-chem. Kjeldahl method. The relative standard deviations for 10 replicates of each wastewater were less than 3.5%. No matrix or solvent effects were found. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Reference of 934-48-5).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Reference of 934-48-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The Reactivity Trends in Electrochemical Chlorination and Bromination of N-Substituted and N-Unsubstituted Pyrazoles* was written by Lyalin, B. V.;Petrosyan, V. A.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2014.Application of 15953-73-8 This article mentions the following:

The authors’ study of electrochem. chlorination and bromination of pyrazoles decorated with electron-withdrawing and electron-donating groups showed that the product yield and composition depended on the substitution at the N-1 atom. The authors showed for the 1st time the significant differences in halogenation reactivity patterns of N-unsubstituted and N-alkylpyrazoles. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Application of 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Application of 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Transition metal azolates from metallocenes. Part 1: Dimetallic and trimetallic cyclopentadienylnickel pyrazolates, synthesis and structural studies was written by Rettig, Steven J.;Storr, Alan;Summers, David A.;Thompson, Robert C.;Trotter, James. And the article was included in Canadian Journal of Chemistry in 1997.Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

The reactions of nickelocene with pyrazoles in benzene solution gave either dimeric compounds, [CpNi(μ-pz)]₂, (room temperature conditions) or trimetallic complexes, [CpNi(μ-pz)₂]₂Ni, (elevated temperature conditions). Both dimeric and trimetallic species were obtained as red crystalline materials and x-ray structural studies are reported for representative samples of each type. Structural features are interpreted and compared with similar, previously reported, Ni pyrazolate structures. Crystals of [CpNi(3,5-diMepz)]₂ (C₂₀H₂₄N₄Ni₂), are orthorhombic, a 15.204(1), b 17.967(2), c 6.9786(9) Å, Z = 4, space group Ama2; those of [CpNi(4-NO₂-3,5-diMepz)]₂ (C₂₀H₂₂N₆Ni₂O₂), are orthorhombic, a 17.145(3), b 17.738(1), c 7.006(1) Å, Z = 4, space group P2₁2₁2₁; those of [CpNi(3,5-F₆diMepz)]₂ (C₂₀H₁₂F₁₂N₄Ni₂), are orthorhombic, a 18.7134(8), b 15.619(2), c 7.7263(9) Å, Z = 4, space group Pnma; those of [CpNi(3,5-diMepz)₂]₂Ni (C₃₀H₃₈N₈Ni₃), are triclinic, a 10.078(2), b 16.134(2), c 9.992(1) Å, α 91.586(10), β 111.050(9), γ 86.95(1)°, Z = 2, space group P1; and those of [CpNi(4-Cl-3,5-diMepz)₂]₂Ni (C₃₀H₃₄Cl₄N₈Ni₃), are monoclinic, a 10.2201(7), b 16.174(1), c 10.7207(9) Å, β 108.193(5)°, Z = 2, space group P2₁la. The structures were solved by direct (dimetallic species) or Patterson (trimetallic complexes) methods and were refined by full-matrix least-squares procedures to R = 0.035, 0.032, 0.058, 0.032, and 0.033 (R_w = 0.021, 0.026, 0.053, 0.028, and 0.032) for 1157, 1894, 1642, 4499, and 2113 reflections with I ≥ 3σ(F²), resp. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

One-pot, procedure for the preparation of some thiazino[2,3-b]quinoxaline derivatives was written by Bakavoli, Mehdi;Eshghi, Hossein;Azizollahi, Hamid;Saberi, Sattar;Bazrafshan, Faezeh. And the article was included in Journal of Chemical Research in 2014.SDS of cas: 51395-52-9 This article mentions the following:

An efficient and convenient synthesis of new thiazino[2,3-b]quinoxaline derivatives I (R = CH₃, C₆H₅, 4-MeC₆H₄, etc.) has been developed by employing a one-pot cyclocondensation of several α-haloketones and 3-aminoquinoxaline-2-thiol in acetic acid. A similar reaction with 4-bromo-3-methyl-4,5-dihydro-1H-5-pyrazolone gave a new heterocyclic system, 3-methyl-1,4-dihydropyrazolo[4′,3′:5,6][1,4]thiazino[2,3-b]quinoxaline. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9SDS of cas: 51395-52-9).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.SDS of cas: 51395-52-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The pyrolytic rearrangement of 1-alkynoyl-3-methylpyrazoles: synthesis of pyrazolo[1,5-a]pyridin-5-ols and related compounds was written by Brown, Roger F. C.;Eastwood, Frank W.;Fallon, Gary D.;Lee, Swee Choo;McGeary, Ross P.. And the article was included in Australian Journal of Chemistry in 1994.COA of Formula: C5H7ClN2 This article mentions the following:

Flash vacuum pyrolysis of 1-(2-alkynoyl)-3-methylpyrazoles (e.g., I; R = H, Me, Ph) at 650°/0.03 mm forms pyrazolo[1,5-a]pyridin-5-ols (e.g., II), often in high yield, which may bear substituents at C2, C3 or C7. In the absence of a 3-Me group in the precursor, N-ethynylpyrazoles are formed in low yield. The formation of both types of product is interpreted as involving 3-(N-pyrazolyl)propadienones formed by N1 → N2 migration of the N-alkynoyl group with inversion of the three-carbon chain. The fused-ring structure of 2-methylpyrazolo[1,5-a]pyridin-5-ol was established by x-ray crystallog. of the O-benzoyl derivative In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8COA of Formula: C5H7ClN2).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.COA of Formula: C5H7ClN2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Lanthanide pyrazolecarboxylates for OLEDs and bioimaging was written by Utochnikova, Valentina V.;Latipov, Egor V.;Dalinger, Alexander I.;Nelyubina, Yulia V.;Vashchenko, Andrey A.;Hoffmann, Michael;Kalyakina, Alena S.;Vatsadze, Sergey Z.;Schepers, Ute;Brase, Stefan;Kuzmina, Natalia P.. And the article was included in Journal of Luminescence in 2018.Reference of 10199-53-8 This article mentions the following:

Novel materials based on lanthanide complexes with six pyrazolecarboxylates were obtained. They possess high solubility due to the purposeful introduction of the nitrogen heteroatom in α-position to the carboxy-group, and their luminescence quantum yields reach 100%. High absorption and non-toxicity allowed their successful use for bioimaging in cellulo. While the special approach to electron transport enhancement allowed using them as OLED emission materials. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8Reference of 10199-53-8).

1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Reference of 10199-53-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of quinazolone and its derivatives as potential fungicides was written by Das, N. B.;Mittra, A. S.. And the article was included in Journal of the Indian Chemical Society in 1979.Computed Properties of C4H5BrN2O This article mentions the following:

Condensation of 4-bromo-2-pyrazolin-5-one with 2-mercapto-3-aryl-4-quinazolones afforded quinazolones I (R = aryl,R¹ = H, Ph). They are fungitoxic against the rice blast pathogen Pyricularia oryzae and brown leaf spot pathogen Helminthosporium oryzae. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Computed Properties of C4H5BrN2O).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Computed Properties of C4H5BrN2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics