Day: January 6, 2023

Acidity constants of some biheterocycles was written by Tjiou, El Mostafa;Fruchier, Alain;Pellegrin, Valdo;Tarrago, Georges. And the article was included in Journal of Heterocyclic Chemistry in 1989.Category: pyrazoles-derivatives This article mentions the following:

The pKa₁ and pKa₂ of 19 biheterocycles of the form R(CH₂)_nR¹ [R, R¹ = (un)substituted imidazolyl, (un)substituted pyrazolyl, 2-pyridyl; n = 0, 1] were determined in H₂O at 25° by potentiometry and UV spectroscopy. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Category: pyrazoles-derivatives).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Weak C-H…O and C-H…N interactions in nitropyrazoles was written by Foces-Foces, C.;Jagerovic, N.;Elguero, J.. And the article was included in Acta Crystallographica, Section C: Crystal Structure Communications in 2000.Name: 1-Methyl-3-nitro-1H-pyrazole This article mentions the following:

The structures of 1-methyl-3-nitropyrazole and 1-methyl-4-nitropyrazole, C₄H₅N₃O₂, were determined The 3-nitro derivative has crystallog. m-symmetry while the 4-nitro compound has no imposed symmetry. The significant differences in bond distances and angles between the structures are ascribable to the electron-withdrawing effects of the nitro group attached to C3 or C4, resp. In both structures, the mols. are organized into layers by an extensive network of C-H…O or C-H…N H interactions. Within a layer, the mols. are arranged in a similar way, although differences of up to 0.3 Å in the analogous H…O or H…N intermol. distances are observed The cohesion of the layers is due to van der Waals and C-H…O contacts. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Name: 1-Methyl-3-nitro-1H-pyrazole).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Name: 1-Methyl-3-nitro-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis and characterisation of palladium(II) and platinum(II) compounds containing pyrazole-derived ligands: crystal structure of [PdCl₂(HL¹)] (HL¹ = 3-phenyl-5-(2-pyridyl)pyrazole) was written by Perez, Jose Antonio;Pons, Josefina;Solans, Xavier;Font-Bardia, Merce;Ros, Josep. And the article was included in Inorganica Chimica Acta in 2005.Related Products of 19959-77-4 This article mentions the following:

Reaction of the ligands 3-phenyl-5-(2-pyridyl)pyrazole (HL¹), 3,5-bis(2-pyridyl)pyrazole (HL²), 3-methyl-5-(2-pyridyl)pyrazole (HL³) and 3-methyl-5-phenylpyrazole (HL⁴) with [MCl₂(MeCN)₂] (M = Pd(II), Pt(II)) or [PdCl₂(cod)] gives [PdCl₂(HL)₂] (HL = HL¹, HL², HL³), [Pt(L)₂] (L = L¹, L², L³) and [MCl₂(HL⁴)₂] (M = Pd(II), Pt(II)). The new complexes were characterized by elemental analyses, conductivity measurements, IR and ¹H NMR spectroscopies. The crystal and mol. structure of [PdCl₂(HL¹)] was resolved by x-ray diffraction, and consists of monomeric cis-[PdCl₂(HL¹)] mols. The Pd center has a typical square planar geometry, with a slight tetrahedral distortion. The tetracoordinated metal atom is bonded to one pyridine N, one pyrazolic N and two chloro ligands in a cis disposition. The ligand HL¹ is not completely planar. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Related Products of 19959-77-4).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Related Products of 19959-77-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Effects of hydrogen bond on the melting point of azole explosives was written by Wang, Jian-Hua;Shen, Chen;Liu, Yu-Cun;Luo, Jin;Duan, Yingjie. And the article was included in Journal of Molecular Structure in 2018.Recommanded Product: 54210-32-1 This article mentions the following:

M.p. is an important index to determine whether an explosive can be a melt cast carrier. In this study, the relationship among the mol. structure, crystal structure, and m.p. of explosives was investigated by using nitroazole compounds Hydrogen bonds influence crystal packing modes in chem. understandable ways. Hydrogen bonds also affect the changes in entropy and enthalpy in balancing melting process. Hence, different types of hydrogen bonds in explosive crystal structures were compared when the relationship between the mol. structure and the m.p. of nitroazole explosives were analyzed. The effects of Me and amino groups on intermol. hydrogen bonds were also compared. Results revealed that the Me and amino groups connected on the N(1) of the heterocyclic compound can reduce the m.p. of azole explosive. This finding is possible because Me and amino groups destroy the intermol. hydrogen bond of the heterocyclic compound In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Recommanded Product: 54210-32-1).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Recommanded Product: 54210-32-1

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Diene synthesis in the pyrazole series. Preparation of 6-anilinopyridines was written by Abjean, Francois. And the article was included in Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques in 1974.Electric Literature of C6H9N3O This article mentions the following:

The anilinopyridinium tetrafluoroborates I (R = Ph, p-O2NC6H4), p-ClC6H4) were formed by treating BF3 complexes of the pyrazoles II with MeO2CCCCO2Me. Treatment of I with KOH gave the pyridineamines III. The pyrazoles II (R = Ac, Bz, CONH2) also formed BF3 complexes which did not undergo diene synthesis, giving instead II (R = H). In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Electric Literature of C6H9N3O).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Electric Literature of C6H9N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Mass spectrometry of nitroazoles. I. The mass spectra of methyl substituted nitropyrazoles was written by Luijten, W. C. M. M.;Van Thuijl, J.. And the article was included in Organic Mass Spectrometry in 1979.COA of Formula: C4H5N3O2 This article mentions the following:

The mass spectra of all isomers of methylnitropyrazoles are reported. Generally, the spectra are characteristic of nitropyrazoles. In some cases however, ortho effects occur, which were recognizable by the primary loss of •OH, H₂O, •CHO and HCHO. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4COA of Formula: C4H5N3O2).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.COA of Formula: C4H5N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Five new mononuclear complexes of 2-(5-methyl-1H-pyrazol-3-yl)pyridine: Synthesis, crystalline architectures through supramolecular interactions and spectroscopy was written by Zhu, Guang-Zhou;Xing, Bei-Bei;Yang, Feng-Lei;Li, Xiu-Ling. And the article was included in Polyhedron in 2014.Recommanded Product: 19959-77-4 This article mentions the following:

Five new mononuclear complexes with 2-(5-methyl-1H-pyrazol-3-yl)pyridine (L) were synthesized, namely [ZnLCl₂] (1), [NiL₂(H₂O)₂]Cl₂·0.5N₂H₄ (2), [MnL₂Cl₂]·3H₂O (3), [CdL₂(NO₃)₂] (4) and [MnL₂(Pa)₂] (5, Pa = m-phthalic acid). All these compounds were characterized by elemental anal., IR and UV-visible spectroscopy, and x-ray single crystal diffraction. The crystal structures reveal that compounds 2, 3 and 5 afford six-coordinated octahedral spheres, while compound 1 displays a four-coordinated tetrahedral core and compound 4 forms an eight-coordinated geometry. Furthermore, the 3D supramol. networks, formed through plentiful H-bonds and weak mol. interactions, were analyzed. The photoluminescent properties of the ligand L, together with compounds 1 and 4, were also studied in methanol solution at room temperature In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Recommanded Product: 19959-77-4).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 19959-77-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

N-Amination of pyrazoles: a general approach was written by Vinogradov, Vasilii M.;Dalinger, Igor L.;Shevelev, Svyatoslav A.. And the article was included in Mendeleev Communications in 1993.Recommanded Product: 5334-39-4 This article mentions the following:

A general approach to N-amination of pyrazoles, allowing the synthesis of previously inaccessible N-aminopyrazoles with electron-acceptor substituents in the ring, has been proposed, consisting of treatment of the pyrazoles with hydroxylamine-O-sulfonic acid in aqueous media at controlled pH depending on the pK_a of the pyrazole. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Recommanded Product: 5334-39-4).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 5334-39-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Determination of volatile flavor compounds in raw and treated duck meats of different body parts was written by Zhen, Zong-Yuan;Liu, Yi-Lin;Wang, Jie;Li, Jing-Jun;Li, Xian-Bao;Zheng, Hai-Bo. And the article was included in Journal of Food Biochemistry in 2022.Product Details of 934-48-5 This article mentions the following:

The compounds in volatile flavor substances in duck meats of three different body parts (breast, leg, and wing) were extracted by headspace solid-phase micro-extraction and determined by gas chromatog.-mass spectrometry. A total of 16 main volatile compounds including 4 hydrocarbons, 4 alcs., 2 acids, 3 aldehydes, and 3 others (N-containing, S-containing) were identified in raw duck meats from three different body parts. The hydrocarbon compounds account for more than 50% of all volatile substances in all three body parts. And the percentage of hydrocarbon compounds in raw duck breast meat reaches 82.76%. A total of 81 volatile compounds including 15 hydrocarbons, 10 alcs., 7 acids, 12 aldehydes, 4 esters, 19 S-containing and N-containing compounds, and 14 others were isolated and identified in 1 h-marinated and cooked duck meats. A total of 101 kinds of volatile flavor compounds including 13 hydrocarbons, 14 alc., 7 acids, 8 aldehydes, 12 esters, 23 S-containing and N-containing compounds, and 24 others were detected in 3 h-marinated duck meats of the three body parts. It was proved in this study that under the same conditions, the volatile compounds in duck legs are more than those in duck breasts and wings, and the types of volatile flavor substances increase significantly in duck meats after cooked. Practical applications Prepared and cooked duck meat, especially wings and legs are popular food in China. The results suggest that Pickling makes duck meat more flavory while proper pickling time is less than 3 h. Duck wings are better for marinating and cooking compared with duck breasts and legs. The acceptance study of duck meat from different body parts and the anal. of volatile flavor compounds are beneficial for optimizing utilization of whole parts of duck meat. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Product Details of 934-48-5).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Product Details of 934-48-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Deprotonation of metal complexes derived from ligands containing pyrrole, pyrazole, and indene residues was written by Chiswell, B.. And the article was included in Inorganica Chimica Acta in 1972.Formula: C9H9N3 This article mentions the following:

The synthesis of several new planar nitrogenous tridentate ligands, specially designed to present their donor atoms at positions very close to the normal octahedral sites of a metal atom, are described. Each of these ligand moieties, when complexed to a metal atom, also possess the potential ability to lose a proton from the periphery of the ligand mol. to yield deprotonated non-charged metal complexes. The lack of change in color and magnetic moment of complexes of these ligands, upon undergoing such deprotonation reactions, is compared with the marked increase in color intensity and decrease in magnetic moment when charged complexes containing a 2-pyridylhydrazine entity in the ligand residue undergo similar deprotonation reactions. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Formula: C9H9N3).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Formula: C9H9N3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics