Day: January 4, 2023

Use of pyrazoles as ligands greatly enhances the catalytic activity of titanium iso-propoxide for the ring-opening polymerization of L-lactide: a cooperation effect was written by Wang, Tzu-Fang;Kosuru, Someswara Rao;Yu, Shu-Chun;Chang, Yung-Chi;Lai, Hsin-Yu;Chang, Yu-Lun;Wu, Kuo-Hui;Ding, Shangwu;Chen, Hsuan-Ying. And the article was included in RSC Advances in 2020.Application of 15953-73-8 This article mentions the following:

Using TiOⁱPr₄ with a pyrazole ligand for one-pot LA polymerization improved catalytic activity compared with using TiOⁱPr₄ only. At 60°, TiOⁱPr₄ with ^furPz exhibited a higher catalytic activity (approx. 3-fold) than TiOⁱPr₄. At room temperature, TiOⁱPr₄ with ^BuPz exhibited a higher catalytic activity (approx. 17-fold) than TiOⁱPr₄. High mol. mass PLA (M_nGPC = 51 100, and D = 1.10) could be produced by using TiOⁱPr₄ with ^furPz in melt polymerization ([TiOⁱPr₄] : [^furPz] = 1000 : 1 : 1 at 100°, 240 min). The crystal structure of ^MePz₂Ti₂OⁱPr₇ revealed the cooperative activation between two Ti atoms during LA polymerization In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Application of 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Application of 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Interaction of sulfaphenazole derivatives with human liver cytochromes P450 2C: molecular origin of the specific inhibitory effects of sulfaphenazole on CYP 2C9 and consequences for the substrate binding site topology of CYP 2C9 was written by Mancy, Annah;Dijols, Sylvie;Poli, Sonia;Guengerich, F. Peter;Mansuy, Daniel. And the article was included in Biochemistry in 1996.Recommanded Product: 3528-58-3 This article mentions the following:

The effects of sulfaphenazole (I) on typical activities catalyzed by human cytochromes P 450 of the 1A, 3A, and 2C subfamilies expressed in yeast were studied. I acts as a strong, competitive inhibitor of CYP 2C9 (K_i = 0.3 ± 0.1 μM); it is much less potent toward CYP 2C8 and 2C18 (K_i = 63 and 29 μM, resp.) and fails to inhibit CYP 1A1, 1A2, 3A4, and 2C19. From difference visible spectroscopy experiments using microsomes of yeast expressing various human P450s, I selectively interacts only with CYP 2C9 with the appearance of a peak at 429 nm as expected for the formation of a P 450 Fe(III)-nitrogenous ligand complex (K_s = 0.4 ± 0.1 μM). Comparative studies of the spectral interaction and inhibitory effects of twelve compounds related to I with CYP 2C9 showed that the aniline function of I is responsible for the formation of the iron-nitrogen bond of the 429 nm-absorbing complex and is necessary for the inhibitory effects of I. The study of two new compounds synthesized during this work, in which the N-Ph group of I was replaced with either an Et group or a 3,4-dichlorophenyl group, showed that the presence of an hydrophobic substituent at position I of the pyrazole function of I is required for a strong interaction with CYP 2C9. A model for the binding of I in the CYP 2C9 active site is proposed; that takes into account three major interactions that should be at the origin of the high-affinity and specific inhibitory effects of I toward CYP 2C9: (i) the binding of its nitrogen atom to CYP 2C9 iron, (ii) an ionic interaction of its SO₂N^– anionic site with a cationic residue of CYP 2C9, and (iii) an interaction of its N-Ph group with an hydrophobic part of the protein active site. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Recommanded Product: 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Recommanded Product: 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Solvatochromism of Heteroaromatic Compounds: XX. 4(5)-Nitroimidazole was written by Vokin, A. I.;Sherstyannikova, L. V.;Krivoruchka, I. G.;Aksamentova, T. N.;Krylova, O. V.;Turchaninov, V. K.. And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) in 2003.Related Products of 54210-32-1 This article mentions the following:

4(5)-Nitroimidazole in solution is stabilized as the 5-nitro isomer due to formation of hydrogen bond with an aprotic protophilic solvent. Amphiprotic medium favors displacement of the tautomeric equilibrium toward the 4-nitro isomer via formation of a solvate complex where 4-nitroimidazole acts as hydrogen bond acceptor. The observed specific solvatochromic effect in the UV spectrum of 4-nitroimidazole and related heterocyclic nitro compounds is determined by the electronic configuration of the excited π,π*-state. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Related Products of 54210-32-1).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Related Products of 54210-32-1

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Heterocyclic fungicides. Part IV was written by Mitra, P.;Mittra, A. S.. And the article was included in Journal of the Indian Chemical Society in 1984.Electric Literature of C4H5BrN2O This article mentions the following:

Thiazolidones I [R = Ph, C₆H₄OMe, C₆H₄NO₂, C₆H₄OH, C₆H₃(OH)OMe, CH:CHPh, C₆H₄NMe₂, furyl] condensed with bromopyrazolinones II (R¹ = H, Ph) to give thiazolidonylpyrazolinones III. At 1000 ppm, III gave 28.0-66.0% inhibition of spore germination for P. oryzae and H. oryzae. The most effective compounds were III (R = Ph, C₆H₄NO₂-2, CH:CHPh, R¹ = H, Ph; R = C₆H₄NO₂-3, C₆H₄OMe, R¹ = Ph), with 51.4-66.0% germination inhibition for both fungi at 1000 ppm. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Electric Literature of C4H5BrN2O).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Electric Literature of C4H5BrN2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reaction of hydrazine hydrate with 4-alkyl-1-cyanoacetylthiosemicarbazides was written by O’Callaghan, C. N.. And the article was included in Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science in 1976.Quality Control of 3,5-Dimethyl-1H-pyrazole-1-carboxamide This article mentions the following:

NCCH2CONHNHCSNHR (R = Me, Et, Pr, PhCH2) were cyclized by H2NNH2.H2O at 20° to cyanomethyltriazolinethiones I, which at higher temperature were converted to II. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Quality Control of 3,5-Dimethyl-1H-pyrazole-1-carboxamide).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Quality Control of 3,5-Dimethyl-1H-pyrazole-1-carboxamide

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

A new synthesis of azopyrazoles by oxidation of C-aminopyrazoles on a NiO(OH) electrode was written by Lyalin, Boris V.;Sigacheva, Vera L.;Kokorekin, Vladimir A.;Petrosyan, Vladimir A.. And the article was included in Mendeleev Communications in 2015.Recommanded Product: 3528-58-3 This article mentions the following:

Oxidation of C-amino-N-alkylpyrazoles on a NiO(OH) electrode in an aqueous alk. medium afforded the corresponding azopyrazoles. The success in implementation of these processes was due to the structure of C-aminopyrazoles. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Recommanded Product: 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Recommanded Product: 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Equilibrium nitrogen acidity of nitrogen heterocycles was written by Terekhova, M. I.;Petrov, E. S.;Rokhlina, E. M.;Kravtsov, D. N.;Shatenshtein, A. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1979.Application In Synthesis of 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

The acid pK values of 18 heterocycles were determined in Me₂SO by spectral observation of the transmetalation equilibrium with indicator CH acids. The pK values ranged from 23.3 for pyrrole to 7.8 for 2,4,5-tribromoimidazole. The pK decreased as the number of N atoms in the ring and the number of annulated benzene rings increased. LFER between pK and Σσ_m were found for imidazoles and pyrazoles. The pK were lower in MeOCH₂CH₂OMe than in Me₂SO. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Application In Synthesis of 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Application In Synthesis of 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Enaminone-derived pyrazoles with antimicrobial activity was written by Bhat, Mashooq Ahmad;Al-Omar, Mohamed A.;Naglah, Ahmed M.;Khan, Abdul Arif. And the article was included in Journal of Chemistry in 2019.Recommanded Product: 73387-46-9 This article mentions the following:

A series of pyrazoles I [R = 4-methoxy, 4-bromo, 4-morpholino, etc.; R¹ = H, 2-phenylacetyl] derived from the substituted enaminones were synthesized and were evaluated for antimicrobial activity. All the compounds were characterized by the spectral data and elemental anal. Thesynthesized compounds were initially screened for their antimicrobial activity against ATCC 6538, NCTC 10400, NCTC 10418 and ATCC 27853. During initial screening, compounds I [R = 2,4,6-trimethoxy; R¹ = H, R = 2,4-dimethoxy; R¹ = H, R = 4-bromo; R¹ = H] presented significant antimicrobial activity through disk diffusion assay. These compounds were further evaluated for antimicrobial activity at different time points against Gram-pos. and Gram-neg. bacteria and presented significant activity for 6h. The activity was found to be greater against Gram-pos. bacteria. In contrast at 24h, the activity was found only against Gram-pos. bacteria except compound I [R = 4-bromo; R¹ = H], showing activity against both types of bacteria. Compound I [R = 4-bromo; R¹ = H] was found to have highest activity against both Gram-pos. and Gram-neg. bacteria. In the experiment, the researchers used many compounds, for example, 3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9Recommanded Product: 73387-46-9).

3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Recommanded Product: 73387-46-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Facile and environmentally friendly synthesis of nitropyrazoles using montmorillonite K-10 impregnated with bismuth nitrate was written by Ravi, P.;Tewari, Surya P.. And the article was included in Catalysis Communications in 2012.Recommanded Product: 3-Methyl-4-nitro-1H-pyrazole This article mentions the following:

Nitropyrazoles in higher yields were synthesized using montmorillonite K-10 impregnated with bismuth nitrate and the present procedure may be applied for the nitration of a wide variety of azoles in the drug and pharmaceutical industries. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Recommanded Product: 3-Methyl-4-nitro-1H-pyrazole).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Recommanded Product: 3-Methyl-4-nitro-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics