Calculation of one-electron reduction potentials for nitroheterocyclic hypoxia-selective agents was written by Beveridge, Allan J.;Williams, Mark;Jenkins, Terence C.. And the article was included in Journal of the Chemical Society, Faraday Transactions in 1996.Quality Control of 1-Methyl-3-nitro-1H-pyrazole This article mentions the following:
Theor. one-electron reduction potentials, E1, have been determined for a set of eight nitroarene hypoxic cell radiosensitizers using a combination of classical statistical mechanics and quantum mech. methods. Gas-phase electron affinities were calculated using lab initio Hartree-Fock calculations and relative hydration energies were computed using the free energy perturbation (FEP) method. The results were used to estimate the relative one-electron reduction potentials for these mols. in solution In general, the computed results are in good agreement with experiment although further work is required by determine the limitations of the method. Nevertheless, the method shows sufficient promise to be of value in the rational design of improved oxidative agents for use as hypoxia-selective radiosensitizers and bioreductivity activated cytotoxins. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Quality Control of 1-Methyl-3-nitro-1H-pyrazole).
1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Quality Control of 1-Methyl-3-nitro-1H-pyrazole
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics