Day: December 1, 2022

Bouaik, Hassan published the artcileOptimal parameters and structural composition of bio-oil and biochar from intermediate pyrolysis of red algal biomass, Related Products of pyrazoles-derivatives, the publication is Comptes Rendus Chimie (2021), 24(Spec.Iss.1), 1-15, database is CAplus.

Intermediate pyrolysis of red algal biomass was performed in a fixed-bed tubular reactor. To study the parametric effect on product distribution, the experiments were carried out at different temperatures ranging from 400 to 600 °C and different heating rates of 15, 30 and 50 °C/min. The objective of this study is to understand the effect of pyrolysis temperature and heating rate on the yields and compositions of the pyrolysis products of red algal biomass. The bio-oil, biochar and biogas yields ranged between 33 and 45 wt%, 29 and 42 wt%, and 18 and 35 wt%, resp., at different pyrolysis conditions. The highest bio-oil yield (45.02%) was obtained at 450 °C temperature at a heating rate of 50 °C/min. The bio-oil was characterized by proximate and ultimate anal., FTIR, 1H-NMR and GC-MS anal. whereas the biochar was characterized by proximate, ultimate, FTIR, SEM and BET. Higher heating value and d. of the bio-oil were 20.11 MJ/kg, 1289 kg/m³, resp. The bio-oil with relatively high fuel potential can be obtained from the pyrolysis of the red algal biomass. The characterization of bio-oil showed a high percentage of aliphatic functional groups and presence of phenolic, ketone- and nitrogen-containing groups. The characterization results showed that the bio-oil obtained from red algal biomass can be potentially valuable as a source of value-added chems. The biochar obtained with a high heating value of 22.89 MJ/kg can be used as an adsorbent as well as a solid fuel.

Comptes Rendus Chimie published new progress about 890590-91-7. 890590-91-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid, name is 3-Isopropyl-1H-pyrazole-5-carboxylic acid, and the molecular formula is C7H10N2O2, Related Products of pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Liu, Zheng published the artcileC-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors, Application In Synthesis of 724710-02-5, the publication is Bioorganic & Medicinal Chemistry (2016), 24(8), 1757-1770, database is CAplus and MEDLINE.

A series of C-3 phenyl- and heterocycle-substituted derivatives of C-3 deoxybetulinic acid and C-3 deoxybetulin was designed and synthesized as HIV-1 maturation inhibitors (MIs) and evaluated for their antiviral activity and cytotoxicity in cell culture. A 4-subsituted benzoic acid moiety was identified as an advantageous replacement for the 3’3′-dimethylsuccinate moiety present in previously disclosed MIs that illuminates new aspects of the topog. of the pharmacophore. The new analogs exhibit excellent in vitro antiviral activity against wild-type (wt) virus and a lower serum shift when compared with the prototypical HIV-1 MI bevirimat (1, BVM), the first MI to be evaluated in clin. studies. Compound 9a exhibits comparable cell culture potency toward wt virus as 1 (WT EC₅₀ = 16 nM for 9a compared to 10 nM for 1). However, the potency of 9a is less affected by the presence of human serum, while the compound displays a similar pharmacokinetic profile in rats to 1. Hence 9a, the 4-benzoic acid derivative of deoxybetulinic acid, represents a new starting point from which to explore the design of a 2nd generation MI.

Bioorganic & Medicinal Chemistry published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Application In Synthesis of 724710-02-5.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Fuse, Shinichiro published the artcileDesign, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity, Application of 1-Methylpyrazole, the publication is Bioorganic & Medicinal Chemistry (2020), 28(1), 115207, database is CAplus and MEDLINE.

In this study, indeno[2,1-c]pyrazolones, compounds I [Y = C, N; R¹ = H, Me; R² = H, Me, Ph, etc] were designed as readily available synthetic inhibitors of HIF-1 transcriptional activity. Nine compounds were synthesized in 4-5 steps from com. available starting materials. In evaluations of the ability to inhibit the hypoxia-induced transcriptional activity of HIF-1, compound I [Y = C, R¹ = H, R² = 4-MeC₆H₄] showed a higher level compared with that of known inhibitor, YC-1. The compound I [Y = C, R¹ = H, R² = 4-MeC₆H₄] suppressed HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA.

Bioorganic & Medicinal Chemistry published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Application of 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Karthik, Murugan published the artcileGraphene Oxide as a Carbocatalyst for Sustainable ipso-Hydroxylation of Arylboronic Acids: A Simple and Straightforward Strategy To Access Phenols, Category: pyrazoles-derivatives, the publication is ACS Sustainable Chemistry & Engineering (2019), 7(9), 9028-9034, database is CAplus.

A metal-free and straightforward protocol for the synthesis of phenols from aryl and heteroaryl boronic acids has been demonstrated using graphene oxide as a carbocatalyst. This sustainable ipso-hydroxylation takes place under mild conditions using aqueous H₂O₂ as an oxidant in a water medium in a short time under organocatalytic and base-free conditions. The control experiments reveal that the presence of carboxyl groups promotes ipso-hydroxylation. The developed methodol. offers GO as a benign solid-acid catalyst with good sustainability which can be reused several times without significant loss in its catalytic activities; this was proven by the Fourier transform IR and powder X-ray diffraction studies of the reused catalyst.

ACS Sustainable Chemistry & Engineering published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Song, Song published the artcileEfficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization, COA of Formula: C4H6N2, the publication is Organic Letters (2015), 17(12), 2886-2889, database is CAplus and MEDLINE.

An efficient and practical system for inexpensive bromination and iodination of arenes as well as heteroarenes by using readily available DMSO (DMSO) and HX (X = Br, I) reagents is reported. This mild oxidative system demonstrates a versatile protocol for the synthesis of aryl halides. HX (X = Br, I) are employed as halogenating reagents when combined with DMSO which participates in the present chem. as a mild and inexpensive oxidant. This oxidative system is amenable to late-stage bromination of natural products. The kilogram-scale experiment (>95% yield) shows great potential for industrial application.

Organic Letters published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C3H5BN2O2, COA of Formula: C4H6N2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Li, Hao published the artcileEfficient Synthesis of 1,9-Substituted Benzo[h][1,6]naphthyridin-2(1H)-ones and Evaluation of their Plasmodium falciparum Gametocytocidal Activities, COA of Formula: C3H5BN2O2, the publication is ACS Combinatorial Science (2017), 19(12), 748-754, database is CAplus and MEDLINE.

A novel three-component, two-step, 1-pot nucleophilic aromatic substitution (S_NAr)-intramol. cyclization-Suzuki coupling reaction was developed for the synthesis of benzo[h][1,6]naphthyridin-2(1H)-ones (Torins). On the basis of the new efficiently convergent synthetic route, a library of Torin 2 analogs was synthesized. The antimalarial activities of these compounds were evaluated against asexual parasites using a growth inhibition assay and gametocytes using a viability assay.

ACS Combinatorial Science published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, COA of Formula: C3H5BN2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Yang, Xiaoqun published the artcileAsymmetric Synthesis of Structurally Sophisticated Spirocyclic Pyrano[2,3-c]pyrazole Derivatives Bearing a Chiral Quaternary Carbon Center, Name: 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, the publication is Organic Letters (2022), 24(29), 5474-5479, database is CAplus and MEDLINE.

A carbene-catalyzed enantio- and diastereoselective [2 + 4] cycloaddition reaction is developed for quick and efficient access to structurally complex multicyclic pyrano[2,3-c]pyrazole mols. I (R = Me, Ph, 1-naphthyl, etc.; R¹ = H, Me, F; R² = H, Br, F; R³ = H, Me; R⁴ = Me, Bn, Ac, H; R⁵ = Me, Ph, 2-chlorophenyl). The reaction tolerates a broad scope of substrates bearing various substitution patterns, with the multicyclic pyrano[2,3-c]pyrazole products I afforded in generally good to excellent yields and optical purities. The chiral mols. obtained from this approach have found promising applications in the development of novel bactericides for plant protection.

Organic Letters published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C5H8N2O, Name: 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Teng, Qing-Hu published the artcileDesign, syntheses and antitumor activities evaluation of 1,5-diaryl substituted pyrazole secnidazole ester derivatives, Computed Properties of 13599-22-9, the publication is Journal of Heterocyclic Chemistry (2021), 58(8), 1656-1664, database is CAplus.

According to the drug hybridization principle, a series of novel 1,5-diaryl substituted pyrazole secnidazole ester derivatives I (R¹ = 4-I, 3-Me, 4-Cl, etc.; R² = H, Me, Cl) have been synthesized by the combinations of various 1,5-diarylpyrazole-3-carboxylic acids II with secnidazole. The in vitro antitumor/cytotoxicities activities against tumor and normal cell lines, including NCI-H460 (lung tumor cell), MCG-803 (gastric tumor cell), Skov-3 (ovarian tumor cell), BEL-7404 (liver tumor cell) and HL-7702 (normal liver cell), have been evaluated using MTT assay. All compounds I showed promising inhibitory activities against four tumor cell lines. The IC₅₀ of I (R¹ = 4-I; R² = H) against the BEL-7404 cell was 2.03μM, and those of I (R¹ = 3-Me; R² = H) against the NCI-H460, MCG-803 and Skov-3 were 1.34, 0.14, and 0.87μM, resp. All these values were much lower than those of the cisplatin. Furthermore, I (R¹ = 3-Me, R² = H; R¹ = 4-I, R² = H) were also verified to be considerably safe for normal human liver cell, since the lower IC₅₀ values than cisplatin. Based on these results, the cell cycle anal., apoptosis ratio detection and mitochondrial membrane potential assay of I (R¹ = 3-Me, R² = H; R¹ = 4-I, R² = H) were further performed aiming to investigate their inhibition mechanism of BEL-7404 cells. It is revealed that they have effectively inhibited the cell growth by arresting the BEL-7404 cells at S phase and induced apoptosis through the mitochondria-mediated pathway.

Journal of Heterocyclic Chemistry published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C8H15ClN2, Computed Properties of 13599-22-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Toonchue, Saowanee published the artcileMetal-free direct oxidative C-C bond coupling of pyrazolones and quinoxalinones, Product Details of C10H9ClN2O, the publication is Organic Chemistry Frontiers (2018), 5(12), 1928-1932, database is CAplus.

A highly efficient transition metal-free oxidative chemo- and regioselective C-C bond coupling of pyrazolones and quinoxalinones mediated by K₂S₂O₈ was described. This reaction was conveniently carried out under mild conditions which gave various hydroxy-pyrazolyl quinoxalinone products in moderate to excellent yields in a short reaction time.

Organic Chemistry Frontiers published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C5H5NO3S, Product Details of C10H9ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Gouda, Ayman A. published the artcileDevelopment of cloud-point extraction method for preconcentration of trace quantities of cobalt and nickel in water and food samples, Related Products of pyrazoles-derivatives, the publication is RSC Advances (2016), 6(96), 94048-94057, database is CAplus.

A new, efficient, and sensitive cloud point methodol. was developed for preconcentration of trace quantities of cobalt and nickel in water and food samples prior to their determination by flame at. absorption spectrometry (FAAS). The metals react with 2-(benzothiazolylazo)-4-nitrophenol (BTANP) at pH 7.0 and micelle-mediated extraction using the nonionic surfactant Triton X-114 medium. The surfactant-rich phase was diluted with acidified methanol and the cobalt and nickel content was determined by FAAS. The optimum conditions (e.g. pH, reagent and surfactant concentrations, temperature and centrifugation times) were evaluated and optimized. The proposed CPE method showed linear calibration within the ranges 5.0-100 and 5.0-150 ng mL^-1 of cobalt and nickel, resp., and the limits of detection of the method was 1.4 and 1.0 ng mL^-1 of cobalt and nickel, resp. The interference effect of some cations and anions was also studied. The method was applied to the determination of both metals in water and food samples with a recovery from the spiked water samples in the range of 95-102%. The validation of the procedure was carried out by anal. of a certified reference material.

RSC Advances published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Related Products of pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics