Day: November 25, 2022

Pan, Fu-de published the artcileDetermination of total amount of rare earth elements in tea by arsenazo III-spectrophotometry coupled with extraction with PMBP, Name: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Lihua Jianyan, Huaxue Fence (2016), 52(1), 93-95, database is CAplus.

In the work, the sample was subjected to mixed acid digestion, the test solution was purified by combined masking, extraction, and back extraction methods, and the content of rare earth elements was determined by arsenazo III-spectrophotometry. The results of the method were accurate and reliable. Spectrophotometry had the advantages of simplicity, fastness, low cost, etc., and had the significance of popularization and application.

Lihua Jianyan, Huaxue Fence published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Name: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Zhu, Luqun published the artcileA trinuclear [Zn₃(L)₂(OAc)₂] complex based on the asymmetrical bis-Schiff-base ligand H₂L for ring-opening copolymerization of CHO and MA, Application of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Inorganic Chemistry Communications (2013), 182-185, database is CAplus.

Based on asym. bis-Schiff-base ligand H₂L from o-vanillin and the half-unit Schiff-base precursor HL synthesized from 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone (PMBP) and o-phenylenediamine, a trinuclear [Zn₃(L)₂(OAc)₂] (1) is obtained. In complex 1, the unsaturated five and four-coordinate coordination environment for the catalytic active centers (Zn²⁺ ions) permits the monomer insertion for the effective bulk or solution copolymerization of CHO (cyclohexene oxide) and MA (maleic anhydride) in the presence of co-catalyst of DMAP (4-(dimethylamino)pyridine), TPP (triphenylphosphine) or n-Bu₄NBr. All the bulk copolymerizations afford poly(ester-co-ether)s, while some of the solution copolymerizations produce perfectly alternating polyester copolymers. Of the three co-catalysts, DMAP is found to be the most efficient, while an excess thereof is detrimental for chain growth of the copolymers.

Inorganic Chemistry Communications published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C12H16N2O2, Application of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Wu, Jing published the artcileElectronic and steric effects of substituents in series of Zn²⁺ asymmetrical bis-Schiff-base ligands complexes on catalytic ring-opening copolymerization of CHO and MA, SDS of cas: 4551-69-3, the publication is Journal of Organometallic Chemistry (2014), 302-311, database is CAplus.

Based on the half-unit Schiff-base ligand HL and series of asym. bis-Schiff-base ligand H₂Lⁿ (n = 1-6) in situ synthesized from the reaction of 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone (PMBP), o-phenylenediamine, and/or different salicylaldehyde derivatives, complexes [Zn(L)₂] (1) and series of [Zn(Lⁿ)] (n = 1-6, 2-7) are obtained, resp. Complex 1 proves to be inactive, resulting from its saturated octahedral coordination environment around the central Zn²⁺ ion, while in complexes 2-7, the unsaturated coordination environment for the catalytic active centers (Zn²⁺ ions) permits the monomer insertion for the effective bulk or solution copolymerization of CHO (cyclohexene oxide) and MA (maleic anhydride). As to the electron and steric effect in complexes 2-7 on the catalytic behaviors, the copolymerization results show that the introduction of withdrawing -Br substituent para to the phenoxide group endows higher reactive activity, while the bulkiness effect of the encumbering substituent (-Br, -OMe or tert-butyl) ortho to the phenoxide groups is in favor of the chain growth of the copolymers. Moreover, all the bulk copolymerizations in 2-7/DMAP (4-(dimethylamino)pyridine) systems afford poly(ester-co-ether)s, while lower catalyst and co-catalyst concentration for 3/DMAP system is helpful for the formation of perfectly alternating polyester in solution Of the three co-catalysts, DMAP is found to be the most efficient, while an excess thereof is detrimental for the chain growth of the copolymers.

Journal of Organometallic Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, SDS of cas: 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Li, Fang published the artcileMetal-ion controlled solid-state reactivity and photoluminescence in two isomorphous coordination polymers, Quality Control of 19959-71-8, the publication is Inorganic Chemistry Frontiers (2014), 1(2), 172-177, database is CAplus.

Reactions of [M(NH₃)₂]OH (M = Ag and Cu) and 4-(1H-pyrazol-4-yl)pyridine (Hpypz), using p-xylene (C₈H₁₀) as the template, gave isomorphous two-dimensional porous metal azolate frameworks [Ag₂(pypz)₂]·0.5C₈H₁₀ (MAF-36(Ag), 1·g) and [Cu₂(pypz)₂]·0.5C₈H₁₀ (MAF-36(Cu), 2·g). Powder and single-crystal x-ray diffraction studies showed that, upon guest removal, 1·g transformed into a three-dimensional nonporous framework [Ag₆(pypz)₆] (1‘), while 2·g can retain its porous two-dimensional structure. Depending on the metal ion, framework flexibility/rigidity, and/or porosity, 1·g and 2·g, as well as their guest-free derivatives, showed distinctly different photoluminescence and guest-responsive behaviors.

Inorganic Chemistry Frontiers published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Quality Control of 19959-71-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Pan, Zhongwei published the artcileStudies on extraction equilibrium of rare earths in ion liquid extraction system using 1-butyl-3-methyl-imidazolium hexafluorophosphate and 1-phenyl-3-methyl-4-benzoyl-pyrazolone-5, Formula: C17H14N2O2, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2013), 602-604(Pt. 2), 887-891, database is CAplus.

The extraction equilibrium of four rare earth ions (REⁿ⁺, n = 3 or 4) was investigated in ionic liquid (IL) extraction system using 1-butyl-3-methyl-imidazolium hexafluorophosphate ([Bmim]PF₆) ionic liquid as extraction solvent and 1-phenyl-3-methyl-4-benzoyl-pyrazolone-5 (HPMBP, HP) as extractant. The extraction percentage could be higher than 99%. The extracted species in the REⁿ⁺-[Bmim]PF₆-HP system was neutral REP_n (n = 3 or 4) and complete recovery of REⁿ⁺ extracted into [Bmim]PF₆ can be achieved using diluent HCl as stripping agent. [Bmim]PF₆ can be recycled in the experiment The extraction equilibrium constants and the pH_1/2 values of four REs and their separation factors between adjacent rare earths were estimated and comparatively studied.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Formula: C17H14N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Tng, Jiahui published the artcileAchiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation, Recommanded Product: 1H-Pyrazole-4-boronic acid, the publication is Journal of Medicinal Chemistry (2020), 63(11), 5956-5971, database is CAplus and MEDLINE.

AR-42 is an orally active inhibitor of histone deacetylases (HDACs) in clin. trials for multiple myeloma, leukemia, and lymphoma. It has few hydrogen bond donors and acceptors but is a chiral 2-arylbutyrate and potentially prone to racemization. We report achiral AR-42 analogs incorporating a cycloalkyl group linked via a quaternary carbon atom, with up to 40-fold increased potency against human class I HDACs (e.g., JT86, IC₅₀ 0.7 nM, HDAC1), 25-fold increased cytotoxicity against five human cancer cell lines, and up to 70-fold less toxicity in normal human cells. JT86(I) was ninefold more potent than racAR-42 in promoting accumulation of acetylated histone H4 in MM96L melanoma cells. Mol. modeling and structure-activity relationships support binding to HDAC1 with tetrahydropyran acting as a hydrophobic shield from water at the enzyme surface. Such potent inhibitors of class I HDACs may show benefits in diseases (cancers, parasitic infections, inflammatory conditions) where AR-42 is active.

Journal of Medicinal Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C15H23BO2, Recommanded Product: 1H-Pyrazole-4-boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Tng, Jiahui published the artcileAchiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation, Name: (1H-Pyrazol-5-yl)boronic acid, the publication is Journal of Medicinal Chemistry (2020), 63(11), 5956-5971, database is CAplus and MEDLINE.

AR-42 is an orally active inhibitor of histone deacetylases (HDACs) in clin. trials for multiple myeloma, leukemia, and lymphoma. It has few hydrogen bond donors and acceptors but is a chiral 2-arylbutyrate and potentially prone to racemization. We report achiral AR-42 analogs incorporating a cycloalkyl group linked via a quaternary carbon atom, with up to 40-fold increased potency against human class I HDACs (e.g., JT86, IC₅₀ 0.7 nM, HDAC1), 25-fold increased cytotoxicity against five human cancer cell lines, and up to 70-fold less toxicity in normal human cells. JT86(I) was ninefold more potent than racAR-42 in promoting accumulation of acetylated histone H4 in MM96L melanoma cells. Mol. modeling and structure-activity relationships support binding to HDAC1 with tetrahydropyran acting as a hydrophobic shield from water at the enzyme surface. Such potent inhibitors of class I HDACs may show benefits in diseases (cancers, parasitic infections, inflammatory conditions) where AR-42 is active.

Journal of Medicinal Chemistry published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C22H32O2, Name: (1H-Pyrazol-5-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Solum, Eirik J. published the artcileSynthesis and biological evaluation of analogs of didehydroepiandrosterone as potential new anticancer agents, Name: 1H-Pyrazole-4-boronic acid, the publication is Molecules (2020), 25(13), 3052, database is CAplus and MEDLINE.

The synthesis, cytotoxicity and inhibition of CDK8 by thirteen analogs I (Ar = C₆H₅, isoquinolin-5-yl, indole-5-yl, etc.) of cortistatin A are reported. These efforts revealed that the analogs with either a 6- or 7-isoquinoline or 5-indole side chain in the 17-position are the most promising anti-proliferative agents. These compounds exhibited potent cytotoxic effects in CEM, HeLa and HMEC-1 cells. All three compounds exhibited IC₅₀ values < 10μM. The analog I (Ar = indole-5-yl) exhibited an IC50 value of 0.59μM towards the human dermal microvascular endothelial cell line (HMEC-1), significantly lower than the reference standard 2-methoxyestradiol. At a concentration at 50 nM the most potent I (Ar = isoquinolin-5-y) compound reduced the activity of CDK8 to 35%.

Molecules published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C7H4ClIO2, Name: 1H-Pyrazole-4-boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Liu, Mingming published the artcileDiscovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis, Computed Properties of 763120-58-7, the publication is Journal of Medicinal Chemistry (2019), 62(20), 9299-9314, database is CAplus and MEDLINE.

In order to discover novel hypoxia-inducible factor 1 (HIF-1) inhibitors for the cancer metastasis treatment, 68 new aryl carboxamide compounds were synthesized and evaluated for their inhibitory effect by dual luciferase-reporter assay. Based on five rounds of investigation on structure-activity relationships step by step, compound I was discovered as the most active inhibitor (IC₅₀ = 0.32 μM) with no obvious cytotoxicity (CC₅₀ > 50 μM). It effectively attenuated hypoxia-induced HIF-1α protein accumulation and reduced transcription of vascular epidermal growth factor in a dose-dependent manner, which was further demonstrated by its inhibitory potency on capillary-like tube formation, angiogenesis of zebrafish as well as cellular migration and invasion. Importantly, compound I exhibited antimetastatic potency in breast cancer lung metastasis in the mice model, indicating its promising therapeutic potential for prevention and treatment of tumor metastasis. These results definitely merit attention for further rational design of more efficient HIF-1 inhibitors in the future.

Journal of Medicinal Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Computed Properties of 763120-58-7.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Guo, Jun-ling published the artcileOne-step synthesis and thermal behavior of 1-methyl-3,4,5-trinitropyrazole, Product Details of C4H6N2, the publication is Hanneng Cailiao (2015), 23(3), 304-306, database is CAplus.

1-Methyl-3, 4 ,5-trinitropyrazole (MTNP) as an insensitive energetic compound was one-step synthesized with 1-methylpyrazole via direct nitration using mixture of nitric acid and fuming sulfuric acid for the first time. The structure of MTNP was characterized by IR, NMR, elemental anal., and mass spectrum. The reaction conditions were optimized as following: reaction temperature 90 °C, reaction time 6 h , molar ratio of HNO₃ and fuming sulfuric acid 1 : 8. At this condition, the yield of MTNP can reach up to 15.2%. Thermal behavior of MTNP was studied by DSC. Results show that its decomposition temperature is 272.0 °C, indicating a good heat stability.

Hanneng Cailiao published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Product Details of C4H6N2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics