Day: November 17, 2022

Taylor, Edward C. published the artcile3-Cyano-4-aminopyrazolo[3,4-d]pyrimidine, an azalog of the aglycone of toyocamycin, SDS of cas: 54385-49-8, the main research area is .

cf. CA 63, 602a. Condensation of (NC)2C:C(CN)2 with H2NC(:NH)NH2.HCl followed by hydrolysis gave a good yield of 5-aminopyrazole-3,4-dicarbonitrile (I, R = NH2) (II). Reaction of II with HC(OEt)3 under anhydrous conditions by refluxing 7 h., isolation of the intermediate I (R = N:CHOEt) (III), and treatment with alc. NH3 gave 83% yield of the desired aglycon analog (IV, R = CN) (V). III recrystallized from C5H5N-petroleum ether without special precautions against moisture gave I (R = NHCHO). V refluxed 24 h. in 10% aqueous NaOH and acidified with 9% aqueous HCl gave the acid IV (R = CO2H), sublimed in vacuo to 4-aminopyrazolo[3,4-d] pyrimidine IV (R = H). V in 8% aqueous HCl stirred at 0° with addition of aqueous NaNO2, the mixture boiled and the isolated product recrystallized gave 3-cyano-4(5H)-pyrazolo[3,4-d]pyrimidinone.

Journal of Organic Chemistry published new progress in CAplus about 54385-49-8, 54385-49-8 belongs to class pyrazoles-derivatives, name is 5-Amino-1H-pyrazole-3,4-dicarbonitrile, and the molecular formula is C5H3N5, SDS of cas: 54385-49-8.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Jensen, Bror Skytte published the artcileSynthesis of 1-phenyl-3-methyl-4-acyl-5-pyrazolones, Name: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, the main research area is .

cf. CA 56, 6718d. Condensations of acid chlorides and anhydrides with 1-phenyl-3-methyl-5-pyrazolone in dioxane, catalyzed by suspended Ca(OH)2, give directly and in good yield the following 4-acyl-l-phenyl-3-methyl-5-pyrazolone analogs, which are promising chelating agents for the extraction of metal ions (acyl group, m.p., and % yield given): Ac, 58° (MeOH-H2O), 56; EtCO, 62° (MeOH-H2O), 50; ClCH2CO, 88° (MeOH-H2O) (enol m. 140°), 73; PrCO, 80° (MeOH-H2O), 57; EtOCO, 122° (MeOH-H2O) (enol m. 72°), 46; p-BrC6H4CO, 167° (dioxane-H2O) (enol m. 122°), 82; p-O2NC6H4CO, 200° (dioxane-H20), 79; and F3CCO, 144° (EtOH-H2O) (enol m. 132°), 78. Also prepared is 50% 1-(p-nitrophenyl)-3-methyl-4-benzoyl-5-pyrazolone, m. 174° (keto), 224° (enol) (dioxane-H2O). The method fails to give a product capable of metal extraction with pivalyl chloride. The acid strength of the 4-acylpyrazolones is of the same magnitude as that of carboxylic acids (pK 3-5). Their mol. weights are determined by titration in H2O-alc. with phenolphthalein indicator.

Acta Chemica Scandinavica published new progress in CAplus about 1691-93-6, 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Name: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Jensen, Bror Skytte published the artcileSolvent extraction of metal chelates. II. 1-Phenyl-3-methyl-4-acyl-5-pyrazolones, Synthetic Route of 1691-93-6, the main research area is .

cf. ibid. 1668; CA 56, 6718d. A comparison of the apparent mean complexity constants of various 1-phenyl-3-methyl-4-acyl-5-pyrazolones with Be++, Mn++, Zn++, Pb++, UO2++, La+++, and Th4+ in a CHCl3-H2O system shows a linear relation between the log of the distribution coefficient of an uncharged metal chelate and the log of the distribution coefficient of the un dissociated chelating agent, the slope of the line being characteristic of the metal ion. As expected, an increase of the aliphatic side-chain increases the lipophilic character of the chelating agent, and hence increases its distribution coefficient between organic phase and H2O. In the titration experiments, the chelating agents and the metal salts were 0.05 and 0.005M, resp.; when the media become alk. the metals forming slightly soluble hydroxides often precipitate out. Although some acetyl pyrazolones are inferior to, and others superior to, thenoyltrifluoroacetone (I), the caproylpyrazolone offers better separation than I for the above metal ions. As the capacity of the systems involved are rather large, and the separation adequate for many purposes, these compounds show promise as extractive chelating agents for anal. and radiochem. work.

Acta Chemica Scandinavica published new progress in CAplus about 1691-93-6, 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Synthetic Route of 1691-93-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Uzoukwu, B. A. published the artcile1-Phenyl-3-methyl-4-trifluoroacetyl-5-pyrazolone (HPMTFP) as an extraction and spectrophotometric reagent for vanadium (V), Recommanded Product: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, the main research area is vanadium determination extraction spectrophotometry; phenylmethyltrifluoroacetylpyrazolone reagent vanadium determination.

A rapid and efficient method for the determination of a large quantity of V(V) in an aqueous medium using HPMTFP is described. The percentage extraction as a function of pH of aqueous medium is reported and quant. extraction of V(V) occurs in the pH range of 1.7-2.3. The properties of the color of the extracted complex species with respect to pH of solution, various solvents, time and presence of diverse ions are reported. Beer’s law is valid up to 100 ppm of V (V) (ε = 1.1 × 102 L mol-1 cm-1).

Journal of the National Science Council of Sri Lanka published new progress about vanadium determination extraction spectrophotometry; phenylmethyltrifluoroacetylpyrazolone reagent vanadium determination. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Recommanded Product: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Mundra, S. K. published the artcileSynergistic extraction of uranyl ion with acylpyrazolones and dicyclohexano-18-crown-6, Application of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, the main research area is uranyl extraction acylpyrazolone crown synergism.

Synergistic extraction of UO22+ ion with acylpyrazolones such as 1-phenyl-3-methyl-4-trifluoroacetylpyrazolone-5 (HPMTFP, pKa = 2.7), 1-phenyl-3-methyl-4-acetylpyrazolone-5 (HPMAP, pKa = 3.8), or 1-phenyl-3-methyl-4-benzoylpyrazolone-5 (HPMBP, pKa = 4.2) in combination with dicyclohexano-18-crown-6 (DC-18-C6) was studied at various temperatures The results indicate that the equilibrium constants of the organic phase addition reaction, log Ks, at 30° are almost constant (2.72, 2.69, 2.84, resp., for the above 3 systems). The similarity and low log Ks values with DC-18-C6 as compared with TBP systems with these pyrazolones appears to arise due to the limitation to the approach of the large crown ether mol. in bonding with the uranyl chelate. This is in contrast to the fact that the relative basicities of the 2 donors (equilibrium constant for HNO3 uptake) are comparable. Thermodn. data for chelate extraction with HPMTFP evaluated by the temperature coefficient method indicates that a hydrated chelate is extracted into the organic phase. Also, the organic phase addition reaction with DC-18-C6 is stabilized by exothermic enthalpy change, the entropy change counteracting in all the 3 cases.

Journal of Radioanalytical and Nuclear Chemistry published new progress about uranyl extraction acylpyrazolone crown synergism. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Application of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Mao, Jiajun published the artcileSome observations on the synergistic extraction of uranium(VI) with double chelating agent systems, Synthetic Route of 1691-93-6, the main research area is uranium extraction synergism; phenylmethylbenzoglypyrazolone thenoyltrifluoroacetone extraction uranium.

The synergistic extraction was studied of VI) from HNO3 media with double-chelating agent systems 1-phenyl-3-methyl-4-benzoyl-pyrazolone-5 (PMBP) plus thenoyltrifluoroacetone (TTA), and PMBP plus 1-phenyl-3-methyl-4-trifluoroacetylpyrazolone-5 (PMTFP). Some synergistic effects were observed The composition of synergistic complex species is probably UO2PMBP.TTA and UO2PMBP.PMTFP, resp. The equilibrium constants for these synergistic extractions are calculated by 3 methods and the mechanism and the regularity of extraction are discussed as well.

Journal of Radioanalytical and Nuclear Chemistry published new progress about uranium extraction synergism; phenylmethylbenzoglypyrazolone thenoyltrifluoroacetone extraction uranium. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Synthetic Route of 1691-93-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Mao, Jiajun published the artcileSynergistic extraction of uranium(VI) with 1-phenyl-3-methyl-4-acylpyrazolone-5 and neutral extractants, Computed Properties of 1691-93-6, the main research area is uranium extraction phenylmethylacetylpyrazolone neutral extractant; dioctylsulfoxide pyrazolone extraction uranium; TOPO pyrazolone extraction uranium; TBP pyrazolone extraction uranium.

The synergistic extraction of uranium(VI) from hydrochloric acid solution with five chelating agents: 1-phenyl-3-methyl-4-benzoylpyrazolone-5 (PMBP), 1-phenyl-3-methyl-4-acetylpyrazolone-5 (PMAP), 1-phenyl-3-methyl-4-(2′-chlorobenzoyl)pyrazolone-5 (PMCBP), 1-phenyl-3-methyl-4-(p-nitrobenzoyl)pyrazolone-5 (PMNBP) and 1-phenyl-3-methyl-4-trifluoroacetylpyrazolone-5 (PMTFP) plus the neutral extractants TBP, dioctyl sulfoxide (DOSO) and TOPO in chloroform were investigated. The extraction coefficients were greater for such mixtures than the individual component. The formulas of the extracted species were determined to be UO2A2B (where HA = chelating agent, B = neutral extractant). Extraction power of these chelating agents increases as follows: PMCBP > PMNBP > PMTFP = PMBP > PMAP. Synergistic extraction power of the neutral extractants increases as follows: TOPO > DOSO > TBP. The extraction equilibrium constants were calculated The mechanism of the synergistic extraction and possible structure of the extracted species are discussed.

Journal of Radioanalytical and Nuclear Chemistry published new progress about uranium extraction phenylmethylacetylpyrazolone neutral extractant; dioctylsulfoxide pyrazolone extraction uranium; TOPO pyrazolone extraction uranium; TBP pyrazolone extraction uranium. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Computed Properties of 1691-93-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Shakir, Mohammed published the artcile3,4-Dicyano-5-aminopyrazole complexes of anhydrous divalent transition metal chlorides and their triphenylphosphine derivatives, Synthetic Route of 54385-49-8, the main research area is transition metal aminocyanopyrazole complex; pyrazole dicyanoamino transition metal complex; cyanoaminopyrazole transition metal complex.

3,4-Dicyano-5-aminopyrazole (L) reacts either with anhydrous MCl2 or with [M(PPh3)2Cl2] to yield ML4Cl2 (M = Cr, Mn, Fe, Co, Ni, Cu, Zn, Cd, Hg), whose monomeric and covalent natures were confirmed by their solubility in most nonpolar solvents and their low elec. conductivities. The bonding mode of substituted pyrazole is inferred from the position of the ν(C:N) band in the IR spectra. The electronic spectra and the magnetic moments of these compounds were recorded.

Transition Metal Chemistry (Dordrecht, Netherlands) published new progress about transition metal aminocyanopyrazole complex; pyrazole dicyanoamino transition metal complex; cyanoaminopyrazole transition metal complex. 54385-49-8 belongs to class pyrazoles-derivatives, name is 5-Amino-1H-pyrazole-3,4-dicarbonitrile, and the molecular formula is C5H3N5, Synthetic Route of 54385-49-8.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zimmermann, Diane published the artcileUnambiguous synthesis of 1-methyl-3-hydroxypyrazoles, Quality Control of 27412-71-1, the main research area is pyrazolol methyl preparation.

2,3-Dihydropyrazolo[3,2-b]oxazoles were used as intermediates in a new method for preparation of 1-methyl-3-hydroxypyrazoles. Synthesis of this bicyclic system was achieved either by alkylation of 3-hydroxypyrazole with 1,2-dibromoethane or, with better yields, by cyclization of 1-tosyl-2-(2-hydroxyethyl)pyrazol-3-ones via a nitrogen to oxygen transfer of the tosyl group. Alkylation with Me trifluoromethanesulfonate followed by dihydrooxazole ring-opening with sodium iodide led to the 1-methyl-2-(2-iodoethyl)pyrazoles. Removal of the iodoethyl chain on N-2 to give the target 3-hydroxypyrazoles was achieved either via a cyanation and then a decyanoethylation reaction or via an elimination of hydrogen iodide, followed by an iodine-based oxidation of the resulting vinylic derivative Using the latter method, 1-methyl-3-hydroxypyrazoles were obtained in 58-73% yields from the corresponding 2,3-dihydropyrazolo[3,2-b]oxazoles.

Tetrahedron published new progress about pyrazolol methyl preparation. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Quality Control of 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Baddar, F. G. published the artcilePhenylpropiolic acids. IX. Reaction of arylpropiolic acids with hydrazine and phenylhydrazine, Computed Properties of 27412-71-1, the main research area is phenyl propiolic acid hydrazines; propiolic acid phenyl hydrazines; acid phenyl propiolic hydrazines; hydrazines phenyl propiolic acid; pyrazolones; azines aromatic.

Phenyl-, p-chlorophenyl-, and 3,4-methylenedioxyphenylpropiolic acids react with N2H4 to give, in each case, a mixture of the corresponding pyrazol-5-one and azine. p-Methoxyphenyl- and 3,4-dimethoxy-phenylpropiolic acids give azines only. Phenyl-, p-chlorophenyl-, and m-chlorophenylpropiolic acids react with PhNHNH2 to give the corresponding 5-aryl-1-phenylpyrazol-3-ones.

Journal of the Chemical Society [Section] C: Organic published new progress about phenyl propiolic acid hydrazines; propiolic acid phenyl hydrazines; acid phenyl propiolic hydrazines; hydrazines phenyl propiolic acid; pyrazolones; azines aromatic. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Computed Properties of 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics