Day: November 14, 2022

Pal, Sarbani published the artcileHigh speed synthesis of pyrazolones using microwave-assisted neat reaction technology, Related Products of pyrazoles-derivatives, the main research area is keto ester cyclization hydrazine microwave; pyrazolone preparation reaction acrylate; spiro cyclohexane pyrazolone preparation.

A high speed, solvent-free, and practical synthesis of pyrazolones under microwave irradiation was described. This greener synthetic methodol. involves the reaction of β-keto ester with substituted or unsubstituted hydrazine and provides a simple and straightforward one-pot approach for the synthesis of a variety of pyrazolone derivatives with high regioselectivity. These pyrazolones can exist in different tautomeric forms in solution and the aryl ring of 2-aryl pyrazol-3-ones remain twisted with respect to the pyrazole plane in the crystal state. Mechanism of the reaction accounting the regioselectivity was proposed. One of the pyrazolones obtained via this process was utilized to prepare a spiro-cyclohexanone derivative of potential biol. significance.

Journal of the Brazilian Chemical Society published new progress about Hydrazines Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Related Products of pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Schreiner, Ella published the artcileConsecutive Three-Component Synthesis of 2,6-Disubstituted Pyrimid-4(3H)-ones and 1,5-Disubstituted 3-Hydroxypyrazoles Initiated by Copper(I)-Catalyzed Carboxylation of Terminal Alkynes, Recommanded Product: 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is pyrimidone hydroxypyrazole preparation green chem; terminal alkyne carboxylation copper catalyst methylation Michael addition cyclocondensation.

A copper(I)-catalyzed carboxylation of terminal alkynes followed trapping of the carboxylate with Me iodide provides a straightforward access to 3-substituted Me propiolates that can be reacted in the same reaction vessel in a consecutive fashion to give 2,6-disubstituted pyrimid-4(3H)-ones I (R1 = Ph, 4-MeOC6H4, 4-MeC6H4, etc.; R2 = Me, Ph, 4-H2NC6H4, etc.) and 1,5-disubstituted 3-hydroxypyrazoles II (R1 = Ph, 4-MeOC6H4, etc.; R2 = H, Me, Bn, etc.) in moderate to good yields. The Cu(I)-catalyzed carboxylation with carbon dioxide as C1 source therefore provides an environmentally benign entry to three-carbon building blocks in heterocyclic synthesis.

Advanced Synthesis & Catalysis published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Recommanded Product: 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Ihara, Hideki published the artcileRuthenium-catalyzed C-H silylation of methylboronic acid using a removable α-directing modifier on the boron atom, COA of Formula: C9H9N3, the main research area is ruthenium catalyst silylation methylboronic acid; silylborane preparation cross coupling aryl halide palladium catalyst.

Ruthenium-catalyzed C-H silylation of methylboronic acid was achieved by use of 2-(1H-pyrazol-3-yl)aniline as a removable α-directing modifier on the boron atom. Cross-coupling of the product, i.e., (phenyldimethylsilyl)methylpinacolborane, with aryl halides proceeded in the presence of a [PdCl2(dppf)] catalyst and CsOH as a base.

Chemistry Letters published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 111562-32-4 belongs to class pyrazoles-derivatives, name is 2-(1H-Pyrazol-3-yl)aniline, and the molecular formula is C9H9N3, COA of Formula: C9H9N3.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics