Day: November 14, 2022

Heinisch, Gottfried published the artcilePyrazoles. 3. N-1 Protected 4-substituted pyrazoles – synthesis and NMR investigation, SDS of cas: 116228-41-2, the main research area is benzylpyrazole preparation carbon NMR; pyrazole benzyl preparation carbon NMR; benzenesulfonylpyrazole preparation carbon NMR.

Pyrazoles I (R1 = cyano, CO2Et, H; R2 = cyano, CO2Et, CO2H, Ph) and II (R1 = Me, NO2; R2 = H, NO2; R3 = Me, NO2) were prepared, and 13C NMR for I and II were obtained. 1-Benzyl-4-pyrazolecarboxyldehyde was treated with CH2(CO2H)2 to give I (R1 = H, R2 = CO2H). 13C NMR were also obtained for III (R4 = PhCO, PhSO2, tosyl; R5 = H, Br, iodo, substituted ethanyl, Me, NO2; R6 = H, Br).

Heterocycles published new progress about NMR (nuclear magnetic resonance). 116228-41-2 belongs to class pyrazoles-derivatives, name is 4-Bromo-1-tosyl-1H-pyrazole, and the molecular formula is C10H9BrN2O2S, SDS of cas: 116228-41-2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Songsichan, T. published the artcileThiocyanation of Pyrazoles Using KSCN/K2S2O8 Combination, COA of Formula: C9H8N2O, the main research area is pyrazole potassium thiocyanate persulfate promoter regioselective thiocyanation green chem; thiocyanatopyrazole preparation.

A convenient and practical thiocyanation of pyrazoles employed a combination of KSCN and K2S2O8 in DMSO (DMSO) was reported. The salient features of the present reaction included environmentally benign reagents, solvents and simple operation. The reaction showed wide functional group tolerance and gave moderate to excellent yields.

SynOpen published new progress about Cyanation, thiocyanation (regioselective). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, COA of Formula: C9H8N2O.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Perkins, Robert J. published the artcileElectrochemical Nickel Catalysis for Sp2-Sp3 Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides, Product Details of C10H9BrN2O2S, the main research area is electrochem nickel catalysis electrophile coupling reaction alkyl halide.

A constant-current electrochem. method for reducing catalytic Ni complexes in sp2-sp3 cross-electrophile coupling reactions was developed. The electrochem. reduction provides reliable Ni catalyst activation and turnover and offers a tunable parameter for reaction optimization, in contrast to more standard activated metal powder reductants. The electrochem. reactions give yields (i.e., 51-86%) and selectivities as high or superior to those using metal powder reductants and provide access to a wider substrate scope.

Organic Letters published new progress about Coupling reaction catalysts (electrochem.). 116228-41-2 belongs to class pyrazoles-derivatives, name is 4-Bromo-1-tosyl-1H-pyrazole, and the molecular formula is C10H9BrN2O2S, Product Details of C10H9BrN2O2S.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Umetani, Shigeo published the artcileSolvent extraction of alkaline earth metals, and lithium with 1-phenyl-3-methyl-4-acylpyrazol-5-ones and trioctylphosphine oxide, Recommanded Product: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, the main research area is alk earth extraction phenylmethylacylpyrazolone; pyrazolone derivative extraction alk earth; octylphosphine oxide extraction alk earth; lithium extraction pyrazolone derivative.

The synergic extraction of Mg, Ca, Sr, Ba, and Li into cyclohexane or benzene containing 1-phenyl-3-methyl-4-acyl-pyrazol-5-one (HA) [acyl = benzoyl or trifluoroacetyl] and tri-n-octylphosphine oxide (TOPO) was investigated as a function of pH, HA and TOPO concentrations The extracted species when the 4-benzoyl compound was used, were MA2(TOPO)2 (M = Mg, Ca, Sr), BaA2(TOPO)3 and LiA(TOPO)2. When the 4-trifluoroacetyl derivatives was used, the extracted species were the same except for SrA2(TOPO)3. Extraction constants for the synergic extractions were calculated

Analytica Chimica Acta published new progress about Alkaline earth metals Role: PRP (Properties). 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Recommanded Product: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Yamamoto, Takeshi published the artcileRhodium-catalyzed C(sp2)-H addition of arylboronic acids to alkynes using a boron-based, convertible ortho-directing group, Category: pyrazoles-derivatives, the main research area is diarylacrylate dioxaborolanyl diarylethene preparation regioselective diastereoselective; arylboronic acid preparation alkyne addition rhodium catalyst; pyrazolylaniline directed arylboronate borylation.

Temporary modification of a boronyl group with pyrazolylaniline allowed insertion of arylpropiolates and diphenylacetylenes into ortho-C-H bond of arylboronic acids in the presence of rhodium catalysts, giving 3,3-diarylacrylates I [R1 = H, Me, OMe, CF3; R2 = H, Me, Br, OMe, CF3; R3 = H, OMe; R4 = Ph, 1-naphthyl, 2-naphthyl, etc.; R5 = CO2Et, C6H5, 4-CF3C6H4] and diarylethenes II containing aryl groups bearing an o-boryl group stereoselectively. The boronyl group in the 3,3-diarylacrylate I [R1 = R2 = R3 = H, R4 = Ph, R5 = CO2Et] was converted into various functional groups, including chlorine, hydrogen, hydroxy, and aromatic groups.

Chemistry Letters published new progress about Addition reaction catalysts, stereoselective. 111562-32-4 belongs to class pyrazoles-derivatives, name is 2-(1H-Pyrazol-3-yl)aniline, and the molecular formula is C9H9N3, Category: pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Belmar, J. published the artcileSynthesis and tautomerism of new 1-n-alkyl-5-pyrazolone derivatives, Related Products of pyrazoles-derivatives, the main research area is pyrazolone alkylation acylation nitrosation tautomerism.

3-Phenyl-5-pyrazolone (1) is selectively alkylene at position 1 in 40% yield. The alkylated compound (2) is acylated (3) in 60% yield and nitrosated (4) in 80% yield. According to the spectroscopic data a N-H or O-H structure can be proposed for 1 in DMSO. The proton may be at N-2 or on the oxygen at C-5, resp. The alkylated compound 2 exists as 5-pyrazolone in chloroform with a CH2 at C-4. In DMSO, 2 is a 5-hydroxypyrazole. For compound 3 in chloroform the structure corresponds to 4-acyl-5-hydroxypyrazole. For compound 4 in chlorolform there is one tautomer with a 4-nitroso-5-hydroxypyrazole structure while in DMSO the same 4-nitroso-5-hydroxypyrazole (92%) and a 4-nitroso-5-pyrazolone (8%) tautomer can be found.

Boletin de la Sociedad Chilena de Quimica published new progress about Acylation (of 1-alkyl-3-phenyl-5-pyrazolone). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Related Products of pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Wang, Alan X. published the artcileSynthesis and immunosuppressant activity of pyrazolecarboxamides, Quality Control of 217073-76-2, the main research area is pyrazolecarboxamide derivative preparation immunosuppressant activity.

A series of novel pyrazolecarboxamides, e.g., I, is disclosed that demonstrate strong immunosuppressant activity in rodent and human mixed leukocyte response (MLR) assays (IC50 <1 μM). The synthesis, biol. activity, mode of action, and pharmacokinetic properties of this new lead series are discussed. Bioorganic & Medicinal Chemistry Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 217073-76-2 belongs to class pyrazoles-derivatives, name is 1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid, and the molecular formula is C11H9FN2O2, Quality Control of 217073-76-2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Morozov, Oleg S. published the artcileHydrohydrazination of Arylalkynes Catalyzed by an Expanded Ring N-Heterocyclic Carbene (er-NHC) Gold Complex Under Solvent-Free Conditions, COA of Formula: C9H8N2O, the main research area is aryldiazepinylidene gold carbene complex preparation mol crystal structure; diastereoselective hydroamination aryl alkyne hydrazine aryldiazepinylidene gold complex catalyst; hydrazone stereoselective preparation green chem solvent free; aryl alkyne hydrazine hydrohydrazination gold carbene catalyst; expanded ring nitrogen heterocyclic carbene gold complex catalyst.

The gold carbene complex [(THD-Dipp)AuOTf], containing the strongly electron donating, sterically bulky 1,3-bis(2,6-diisopropylphenyl)hexahydro-2H-1,3-diazepine-2-ylidene ligand, was an effective catalyst for the stereoselective hydroamination of aryl alkynes with tosylhydrazine and tert-Bu carbazate under solvent-free conditions to give (E)-tosyl and Boc hydrazones. The structure of (THD-Dipp)AuOTf was determined by X-ray crystallog.

Advanced Synthesis & Catalysis published new progress about Addition reaction, stereoselective (hydrohydrazination). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, COA of Formula: C9H8N2O.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zheng, Zhaoyan published the artcileTautomerism-Dependent Ring Construction of N-Heterocyclic Compounds from the Reactions of 1-Alkynyl Fischer Carbene Complexes and Substituted Pyrazolinones, Safety of 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is pyrazolone fused preparation alkynyl Fischer carbene complex.

Four types of N-heterocyclic ring systems were successfully constructed from the reactions of 1-alkynyl Fischer carbene complexes (OC)5M:C(OEt)CCPh (I, M = Cr, W) and substituted pyrazolinones. Reactions of I with 3-methyl-, 3-propyl-, 3,4-dimethyl-, 3,4-trimethylene-, or 3,4-tetramethylene-2-pyrazolin-5-one generated three kinds of Fischer aminocarbene complexes, and reactions of I with 3-phenyl-2-pyrazolin-5-one and its tautomer 3-phenyl-3-pyrazolin-5-one, gave Fischer alkoxycarbene complexes as the major products and aminocarbene complexes as the minor products. Multiple tautomerism of pyrazolinones is attributed to the versatile formation of N-heterocyclic Fischer carbene complexes. Oxidative demetalation of the complexes with pyridine N-oxide or m-chloroperoxybenzoic acid efficiently afforded organic carbonyl products, and thus, strongly fluorescent syn-mixed-bimanes were prepared The present findings constitute an alternative new method to synthesize mixed bimanes and other novel N-heterocyclic compounds

Journal of Organic Chemistry published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Safety of 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Salvado, Oriol published the artcileStereoselective Cyclopropanation of 1,1-Diborylalkenes via Palladium-Catalyzed (Trimethylsilyl)diazomethane Insertion, Synthetic Route of 111562-32-4, the main research area is diborylalkene preparation silyl cyclopropanation insertion reaction diazomethane; chiral silyl boryl naphthyl cyclopropane preparation crystal structure; mol structure chiral silyl boryl naphthyl cyclopropane; diborylation aldehyde; diborylcyclopropane stereoselective preparation.

Pd catalyzes the cyclopropanation of 2-substituted 1,1-diborylalkenes with (trimethylsilyl)diazomethane. The relative stereoselectivity is controlled via a carbene insertion sequence generating an exclusive anti conformation between the R and SiMe3 substituents. Mixed 1,1-diborylalkenes also contributed to the formation of stereoselective B, B, Si-cyclopropanes. Orthogonal activation with NaOtBu gives protodeborylation preferentially on the B moiety syn to the aryl group. Further oxidation gives access to polyfunctional cyclopropyl alcs. with controlled enantioselectivity when chiral boryl motifs are involved.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 111562-32-4 belongs to class pyrazoles-derivatives, name is 2-(1H-Pyrazol-3-yl)aniline, and the molecular formula is C9H9N3, Synthetic Route of 111562-32-4.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics