Day: November 11, 2022

Anka-Lufford, Lukiana L. published the artcileNickel-Catalyzed Cross-Electrophile Coupling with Organic Reductants in Non-Amide Solvents, SDS of cas: 116228-41-2, the main research area is nickel catalyst cross electrophilic coupling aryl alkyl halide; cross-coupling; green chemistry; heterocycles; homogeneous catalysis; nickel.

Cross-electrophile coupling of aryl halides with alkyl halides has thus far been primarily conducted with stoichiometric metallic reductants in amide solvents. This report demonstrates that the use of tetrakis(dimethylamino)ethylene (TDAE) as an organic reductant enables the use of non-amide solvents, such as acetonitrile or propylene oxide, for the coupling of benzyl chlorides and alkyl iodides with aryl halides. Furthermore, these conditions work for several electron-poor heterocycles that are easily reduced by manganese. Finally, the authors demonstrate that TDAE addition can be used as a control element to ‘hold’ a reaction without diminishing yield or catalyst activity.

Chemistry – A European Journal published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 116228-41-2 belongs to class pyrazoles-derivatives, name is 4-Bromo-1-tosyl-1H-pyrazole, and the molecular formula is C10H9BrN2O2S, SDS of cas: 116228-41-2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Huang, Zhen-Zhong published the artcileA convenient oxidation of 5-substituted pyrazol-3(2H)-ones into methyl 2-alkynoates using poly[4-(diacetoxyiodo)styrene], Category: pyrazoles-derivatives, the main research area is pyrazolone polyacetoxyiodostyrene oxidation ring cleavage; alkynoate preparation; alkyne carboxylate preparation.

An operationally simple oxidation of 5-substituted pyrazol-3(2H)-ones to the corresponding Me 2-alkynoates in good yields with a mediated poly[4-(diacetoxyiodo)styrene] system in methanol and acetonitrile at room temperature was carried out. The polymeric reagent can be regenerated and reused as an environmentally benign reagent.

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about Alkynes Role: SPN (Synthetic Preparation), PREP (Preparation). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Category: pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Bhandari, Shashikant V. published the artcileDesign, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs, Name: 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is diarylpyrazolinone preparation; ethyl acetoacetate diethylmalonate benzoyl chloride condensation cyclocondensation nucleophilic substitution; NSAID inflammation antiinflammatory pain analgesic structure activity vasorelaxant; prostaglandin synthase COX2 inhibitor mol simulation acute ulcerogenicity histopathol.

Various substituted 1,5-diarylpyrazol-3-one derivatives were synthesized and screened for analgesic, anti-inflammatory activities, ulcerogenic potential and for their ability to release nitric oxide. Most compounds exhibited significant analgesic and anti-inflammatory activities. It was interesting to note that out of ten compounds, I (R = H) (59.64%) was found to have anti-inflammatory activity greater than the standard drug Indomethacin (57.89%), whereas II (R = 2-OMe) (57.89%) was found to be equipotent to that of standard, Indomethacin. The pharmacol. studies suggested that the presence of 4-nitro and 2-methoxy on Ph ring at C5 of pyrazole has a significant anti-inflammatory activity and 4-chloro substitution on same Ph ring was found to have decreased activity. However only a Ph substituted derivative was found to have most potent activity. I (R = H) containing plane Ph at C5 of pyrazole was found to have significant analgesic activity (56.86%) in acetic acid induced writhing model. I and II (R = 4-Cl) having 4-chloro substituted Ph ring showed least analgesic activity (10.78%) and (6.86%) resp. The compounds also showed significantly reduced GI-ulcerogenicity and gastroprotective results in histopathol. studies i.e. they were found to be causing no mucosal injury. All the synthesized compounds were found to exhibit significant nitric oxide releasing activity, in both in vitro and in vivo models. Mol. docking studies served to be an important tool for the study of binding of compounds with that of a COX-2 enzyme. The results of the docking studies were found to endorse the result of exptl. work. Thus, the rationale used to design the NCEs was found to produce the promising results as anticipated. Therefore it can be said that the strategy employed can serve as an important tool in future for the design and development of novel therapeutic agents of various categories too.

European Journal of Medicinal Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Name: 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Jung, Jae-Chul published the artcileSynthesis of 3-substituted and 3,4-disubstituted pyrazolin-5-ones, Application In Synthesis of 27412-71-1, the main research area is acetoacetate acid chloride acylation; malonate acid chloride acylation; hydroxybutenoate preparation hydrazine cyclocondensation; alkylidenemalonate preparation hydrazine cyclocondensation; pyrazolinone preparation.

The synthesis of 3-substituted and 3,4-disubstituted pyrazolin-5-ones from acylated Et acetoacetates and di-Et malonates is described. The reaction of acylated Et acetoacetates and di-Et acetylmalonate with hydrazine (98%) gave 3-substituted pyrazolin-5-ones and malonyldihydrazide, resp., following a deacetylation-condensation sequence. The reaction of Et 2-acetyl-3-hydroxy-2-butenoate (I; R = Me) and di-Et 2-(1-hydroxyethylidene)malonate (I; R = EtO) with hydrazine monohydrochloride yielded Et 3,5-dimethyl-1H-pyrazole-4-carboxylate (II) and 4-ethoxycarbonyl-3-methylpyrazolin-5-one (III), resp., following a dehydration-cyclocondensation sequence, in high yields.

Tetrahedron published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Application In Synthesis of 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Li, You published the artcileA one-pot synthesis of omarigliptin and its analogues through stabilized beta-amino ketone intermediate, SDS of cas: 1280210-80-1, the main research area is omarigliptin analog preparation beta amino ketone stabilization reductive amination.

A unique stabilization condition for beta-amino ketone has been described. With the above beta-amino ketone as an unprecedented intermediate, omarigliptin could be prepared in a highly efficient one-pot procedure with good yield. Also with this intermediate, some analogs of omarigliptin were readily prepared for the first time.

Synthetic Communications published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1280210-80-1 belongs to class pyrazoles-derivatives, name is 2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole benzenesulfonate, and the molecular formula is C12H15N3O5S2, SDS of cas: 1280210-80-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Yamamoto, Takeshi published the artcileRegioselective Synthesis of o-Benzenediboronic Acids via Ir-Catalyzed o-C-H Borylation Directed by a Pyrazolylaniline-Modified Boronyl Group, Application of 2-(1H-Pyrazol-3-yl)aniline, the main research area is benzenediboronic acid preparation; iridium catalyzed carbon hydrogen bond borylation arylboronate pyrazolylaniline directed; arylboronic acid iridium catalyzed borylation.

Ir-catalyzed ortho-directed C-H borylation of pyrazolylaniline (PZA)-modified arylboronic acids with bis(pinacolate)diboron afforded o-benzenediboronic acids in which two boronyl groups are differentially modified by pinacol (PIN) and PZA. By using this borylation after nondirected Ir-catalyzed C-H borylation, o-benzenediboronic acids are conveniently synthesized from unfunctionalized arenes. The differentially modified o-benzenediboronic acids undergo selective oxidation and Suzuki-Miyaura cross-coupling at the PZA-modified boronyl groups, affording o-functionalized arylboronic acids selectively.

Organic Letters published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 111562-32-4 belongs to class pyrazoles-derivatives, name is 2-(1H-Pyrazol-3-yl)aniline, and the molecular formula is C9H9N3, Application of 2-(1H-Pyrazol-3-yl)aniline.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Ghani, Lubna published the artcileLiquid-liquid extraction of Eu(lll) using synergic mixture of 1-phenyl-3-methyl-4-trifluoroacetyl-2-pyrazolin-5-one and crown ethers, Quality Control of 1691-93-6, the main research area is europium HPMTFP crown ether liquid extraction.

Synergic extraction of Eu(III) as representative of rare earth elements was conducted with 0.01 mol dm-3 of trifluoroacetyl-pyrazolin-5-one (HPMTFP) and then with synergic mixture of HPMTFP and crown ethers (benzo-15-crown-5, 18-crown-6, 15-crown-5) in dichloromethane (DCM) from aqueous solution having pH 1.0-3.5. Slope anal. method was used for determining the composition of the synergic adduct i.e. Eu(PMTFP)3 that came out to be Eu(PMTFP)3·2S, where S = neutral oxo-donor and -PMTFP = conjugate base of HPMTFP mol. Selective extraction of Eu(III) was found in the presence of various masking agents like citrate, oxalate, bromide, thiosulfate, chromate ions and of some cations. The accuracy of the developed procedure was checked by analyzing real lake sample (IAEA-SL-3) as a reference material.

SN Applied Sciences published new progress about Actinides Role: TEM (Technical or Engineered Material Use), USES (Uses). 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Quality Control of 1691-93-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Ahmadi, Tahereh published the artcileDomino synthesis of quinoxaline derivatives using SBA-Pr-NH2 as a nanoreactor and their spectrophotometric complexation studies with some metals ions, Computed Properties of 27412-71-1, the main research area is diamine aryl multicomponent spirocyclization ninhydrin malononitrile cyanoacetate active methylene; indenoquinoxaline spirocyclic preparation amino SBA catalyst; quinoxaline complexation transition metal.

Amino-functionalized SBA-15 (SBA-Pr-NH2) with a pore size of 6 nm has been used as a basic nanocatalyst in the domino one-pot synthesis of indenoquinoxaline derivatives via the four-component reaction of ninhydrin, 1,2-diaminoarenes, malonodinitrile or Et cyanoacetate, and active methylene compounds using microwave irradiation The solid basic catalyst plays a significant role in catalysis, enhancing the rate and yield of the reaction, it can be easily handled and removed from the reaction mixture by simple filtration and also reused several times without substantial loss of reactivity. Moreover, the complexation reaction between quinoxaline as a model ligand and some metal ions including Cd2+, Co2+, Cu2+, Fe3+, Hg2+, Ni2+, Pb2+, and Zn2+ ions was examined spectrophotometrically in DMF solution at 25 °C. The formation constants of the resulting complexes were calculated from the computer fitting of the molar absorbance measurements in different mole ratios. The obtained data indicated that the stability constant of the resulting complexes varied in the following order Pb2+> Hg2+> Cd2+> Ni2+> Cu2+> Fe3+> Zn2+> Co2+.

Journal of the Iranian Chemical Society published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Computed Properties of 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Fujino, O. published the artcileDetermination of uranium and thorium in apatite minerals by inductively coupled plasma atomic emission spectrometry with solvent extraction separation into diisobutyl ketone, Application In Synthesis of 1691-93-6, the main research area is uranium thorium determination apatite ICP AES.

Determination of the actinide elements (U and Th) in apatite minerals was examined by inductively coupled plasma at. emission spectrometry (ICP-AES) with solvent extraction separation The spectral interference by Ca in the apatite and the neg. interference by the macro-component (Ca phosphate) occurred simultaneously for U and Th. Therefore, after apatite mineral was treated with hot concentrated HNO3, U and Th were separated from Ca phosphate by the solvent extraction method. 1-Phenyl-3-methyl-4-trifluoroacetyl-5-pyrazolone (HPMTFP, pKa=2.56) was used as an extraction reagent. Diisobutyl ketone was selected as the extraction organic solvent. U and Th were quant. extracted over pH 2, and could be separated from the apatite composites. The organic phase was injected directly into the ICP-AES spectrometer. The U and Th contents in apatite minerals from Florida, USA, are 103 ± 2.2 and 8.84 ± 0.19 ppm. These results were quite comparable with those measured with ICP-mass spectrometry (ICP-MS).

Analytica Chimica Acta published new progress about Apatite-group minerals Role: AMX (Analytical Matrix), ANST (Analytical Study). 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Application In Synthesis of 1691-93-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Ihara, Hideki published the artcileEasily Attachable and Detachable ortho-Directing Agent for Arylboronic Acids in Ruthenium-Catalyzed Aromatic C-H Silylation, Recommanded Product: 2-(1H-Pyrazol-3-yl)aniline, the main research area is arylboronic ester silylation regioselective pyrazolylaniline ortho directing ruthenium catalyst; silylated boronic ester Suzuki Miyaura coupling arene.

O-C-H silylation of arylboronic acids has been achieved using 2-pyrazol-5-ylaniline as an ortho-directing agent, which was temporarily attached to the boryl group via Ru-catalyzed silylation with hydrosilanes. Condensation products of arylboronic acids with 2-pyrazol-5-ylaniline were prepared in situ and subjected to reaction with triorganosilanes in the presence of RuH2(CO)(PPh3)3 at 135 °C. Regioselective silylation at their ortho-positions proceeded in good yields for phenylboronic acids bearing para-substituents such as chloro, fluoro, Me, methoxy, and trifluoromethyl groups. P-Methoxycarbonyl-substituted phenylboronic acid provided the corresponding silylated product in moderate yield. M-Tolyl- and 2-naphthylboronic acids underwent silylation selectively at the less sterically hindered ortho-positions. The silylated products were utilized in Suzuki-Miyaura coupling, followed either by iodination with ICl or by Tamao oxidation to furnish iodine- or hydroxy-substituted biaryls.

Journal of the American Chemical Society published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent) (arylboronic acids). 111562-32-4 belongs to class pyrazoles-derivatives, name is 2-(1H-Pyrazol-3-yl)aniline, and the molecular formula is C9H9N3, Recommanded Product: 2-(1H-Pyrazol-3-yl)aniline.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics