Day: November 10, 2022

Uzoukwu, B. A. published the artcileSpectroscopic studies of Th(IV), La(III) and Pb(II) complexes of 4-trifluoroacetyl and 4-trichloroacetyl derivatives of 3-methyl-1-phenylpyrazol-5-one, Product Details of C12H9F3N2O2, the main research area is acetylpyrazolone lanthanum thorium lead complex preparation; lanthanum acetylpyrazolone complex preparation; thorium acetylpyrazolone complex preparation; lead acetylpyrazolone complex preparation.

Th(IV), La(III) and Pb(II) complexes of 4-trifluoroacetyl and 4-trichloroacetyl derivatives of 3-methyl-1-phenylpyrazol-5-one were synthesized and characterized by elemental, UV, IR,1H and 13C NMR spectral studies. Spectral analyses show that the complexes are dehydrated and have the general mol. formula MLn where M(n) = Th(4),La(3) and Pb(2). The analyses further showed that the CO-M bond of metal-trifluoroacetylpyrazolonate complexes are weaker than the metal-trichloroacetylpyrazolonate complexes.

Journal of the National Science Council of Sri Lanka published new progress about. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Product Details of C12H9F3N2O2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Si, Wei-Jie published the artcileDesign, synthesis, antifungal activity and 3D-QSAR study of novel pyrazole carboxamide and niacinamide derivatives containing benzimidazole moiety, Synthetic Route of 769132-77-6, the main research area is pyrazole carboxamide niacinamide benzimidazole preparation antifungal; quant structure activity relationship.

A series of novel pyrazole carboxamide I (R1 = H, Cl, Me; R2 = Me, CF3), II (R1 = H, Cl, Me; R2 = Me, i-Bu) and niacinamide derivatives III (R1 = H, Cl, Me; R2 = H, Cl, SH) containing a benzimidazole moiety were designed and synthesized as antifungal candidate agents. The structure of compound I (R1 = H; R2 = Me) was confirmed by single crystal X-ray diffraction anal. The antifungal activities of the target compounds were evaluated in vitro against four phytopathogenic fungi (namely Botrytis cinerea, Rhizoctonia solani, Fusarium graminearum and Alternaria solani) by the mycelium growth inhibition method. The bioassay results indicated that some of the compounds exhibited good antifungal activity against B. cinerea at 100 μg ML-1 compared to other three fungi. In order to better explore the structure-activity relationship (SAR), the EC50 values of target compounds against B. cinerea were measured and assessed. Subsequently, a 3D quant. structure-activity relationship (3D-QSAR) study was carried out using the comparative mol. field anal. (CoMFA) technique based on the inhibitory activities of tested compounds against B. cinerea. Mol. modeling results revealed fine predictive ability with cross-validated q2 and non-cross-validated r2 values of 0.578 and 0.850, resp.

New Journal of Chemistry published new progress about Fungal plant disease. 769132-77-6 belongs to class pyrazoles-derivatives, name is 3-Isobutyl-1-methyl-1H-pyrazole-5-carboxylic acid, and the molecular formula is C9H14N2O2, Synthetic Route of 769132-77-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics