Day: October 25, 2022

Pyrazole is an organic compound with the formula C3H3N2H. It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms, which are in ortho-substitution. 269410-08-4, formula is C9H15BN2O2, Name is 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Pyrazoles are a class of compounds that have the ring C3N2 with adjacent nitrogen atoms.Notable drugs containing a pyrazole ring are celecoxib (celebrex) and the anabolic steroid stanozolol. Related Products of 269410-08-4.

Lv, Xiu-Liang;Wang, Kecheng;Wang, Bin;Su, Jie;Zou, Xiaodong;Xie, Yabo;Li, Jian-Rong;Zhou, Hong-Cai research published 《 A base-resistant metalloporphyrin metal-organic framework for C-H bond halogenation》, the research content is summarized as follows. Manganese metalloporphyrin, meso-(PzC₆H₄)₄PorMnCl (Pz = 1H-pyrazol-4-yl) was prepared, both free porphine and its manganese complex were reacted with M(OAc)₂ to give metal-organic frameworks, PCN-602(Ni) and PCN-602(Mn), resp. A base-resistant porphyrin metal-organic framework (MOF), namely PCN-602 has been constructed with 12-connected [Ni₈(OH)₄(H₂O)₂Pz₁₂] (Pz = pyrazolate) cluster and a newly designed pyrazolate-based porphyrin ligand, 5,10,15,20-tetrakis(4-(pyrazolate-4-yl)phenyl)porphyrin under the guidance of the reticular synthesis strategy. Besides its robustness in hydroxide solution, PCN-602 also shows excellent stability in aqueous solutions of F^–, CO₃^2-, and PO₄^3- ions. Interestingly, the Mn³⁺-porphyrinic PCN-602, as a recyclable MOF catalyst, presents high catalytic activity for the C-H bond halogenation reaction in a basic system, significantly outperforming its homogeneous counterpart. For the first time, a porphyrinic MOF was thus used as an efficient catalyst in a basic solution with coordinating anions, to the best of our knowledge.

269410-08-4, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, also known as 4-Pyrazoleboronic acid pinacol ester , is a useful research compound. Its molecular formula is C9H15BN2O2 and its molecular weight is 194.04 g/mol. The purity is usually 95%.

4-Pyrazoleboronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. 4-Pyrazoleboronic acid pinacol ester is also a useful reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors.

4-Pyrazoleboronic acid pinacol ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.

4-Pyrazoleboronic acid pinacol ester is an organic compound that is the product of a bifunctional coupling reaction between 4-pyrazolecarboxylic acid and pinacol. It has been shown to inhibit protein S6 kinase, which is involved in the regulation of cell growth and proliferation. This compound has also been shown to be effective against cancer cells, including those that are resistant to conventional chemotherapeutic drugs. 4-Pyrazoleboronic acid pinacol ester may also be used as a precursor for other compounds with pharmaceutical activity., Related Products of 269410-08-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazole is an organic compound with the formula C3H3N2H. It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms, which are in ortho-substitution. 37622-90-5, formula is C6H8N2O2, Name is Ethyl 4-pyrazolecarboxylate. Pyrazoles are a class of compounds that have the ring C3N2 with adjacent nitrogen atoms.Notable drugs containing a pyrazole ring are celecoxib (celebrex) and the anabolic steroid stanozolol. Recommanded Product: Ethyl 4-pyrazolecarboxylate.

Lu, Ke;Xue, Chu-ran;Qiao, Hui;Liu, Shu-wen;Xu, Xiang-wen research published 《 Analysis of aroma composition of litchi ice wine by different extraction fibers》, the research content is summarized as follows. The aroma compounds of litchi ice wine were analyzed by head-space solid-phase micro-extraction (HSSPME) coupled to gas chromatog.-mass spectrometry (GC-MS). The efficiency of three different extraction fibers was evaluated by comparing the number, chem. group and cumulative area normalization value (CANV) of the extracted compounds The results indicated that the extraction efficiency of aroma compounds were very different in litchi ice wine because of different fibers. Totally 62, 56 and 52 aroma compounds in litchi ice wine were extracted through PA, CAR/PDMS and DNB/CAR/PDMS, resp. The major constituents were esters, alcs., acids, ketones, aldehydes, and a few terpenes. The most important aroma compounds were Et caprylate (38.96%), Et caprate (25.14%), Et caproate (9.31%), isoamyl alc. (7.89%), Me methacrylate (1.52%), Et laurate (1.49%), 3-furaldehyde (1.26%), decanoic acid (1.25%), benzyl alc. (1.21%), damascenone (1.21%), and phenethyl alc. (0.30%). The anal. of cumulative area normalization value indicated that 85 μm PA was more sensitive to extract acids but least sensitive to other compounds, 75 μm CAR/PDMS was more sensitive to esters and alcs., and 50/30 μm DNB/CAR/PDMS was more sensitive to ketones and aldehydes. Considering all factors above, 75 μm CAR/PDMS was the optimal fiber for the extraction of aroma compounds in litchi ice wine.

37622-90-5, Ethyl 4-pyrazolecarboxylate, also known as Ethyl pyrazole-4-carboxylate, is a useful research compound. Its molecular formula is C6H8N2O2 and its molecular weight is 140.14 g/mol. The purity is usually 95%.

Ethyl pyrazole-4-carboxylate is a low yield, transition metal salt that is used in the synthesis of pyrazoles. It can be synthesized by the reaction of sodium ethoxide with ethyl chloroformate and a Grignard reagent. Sodium ethoxide is added to a suspension of sodium chloride and dried ethyl chloroformate, followed by addition of magnesium turnings. The mixture is refluxed for one hour, cooled, and filtered to give crystals. Ethyl pyrazole-4-carboxylate is used in the preparation of ethyl esters from aliphatic alcohols by reacting with boron trichloride or phosphorus pentachloride. It participates in certain chemical reactions as a byproduct and can damage equipment during chemical reactions. The yield of this compound can be increased by using an excess amount of Grignard reagent or adding hexamethylenetetramine to the reaction mixture, Recommanded Product: Ethyl 4-pyrazolecarboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Category: pyrazoles-derivatives.

Lloyd, Matthew G.;Huckvale, Rosemary;Cheung, Kwai-Ming J.;Rodrigues, Matthew J.;Collie, Gavin W.;Pierrat, Olivier A.;Gatti Iou, Mahad;Carter, Michael;Davis, Owen A.;McAndrew, P. Craig;Gunnell, Emma;Le Bihan, Yann-Vai;Talbot, Rachel;Henley, Alan T.;Johnson, Louise D.;Hayes, Angela;Bright, Michael D.;Raynaud, Florence I.;Meniconi, Mirco;Burke, Rosemary;van Montfort, Rob L. M.;Rossanese, Olivia W.;Bellenie, Benjamin R.;Hoelder, Swen research published 《 Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket》, the research content is summarized as follows. We describe the optimization of modestly active starting points to potent inhibitors of BCL6 by growing into a subpocket, which was occupied by a network of five stably bound water mols. Identifying potent inhibitors required not only forming new interactions in the subpocket but also perturbing the water network in a productive, potency-increasing fashion while controlling the physicochem. properties. We achieved this goal in a sequential manner by systematically probing the pocket and the water network, ultimately achieving a 100-fold improvement of activity. The most potent compounds displaced three of the five initial water mols. and formed hydrogen bonds with the remaining two. Compound 25 showed a promising profile for a lead compound with submicromolar inhibition of BCL6 in cells and satisfactory pharmacokinetic (PK) properties. Our work highlights the importance of finding productive ways to perturb existing water networks when growing into solvent-filled protein pockets.

Category: pyrazoles-derivatives, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., 761446-44-0.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazoles are synthesized by the reaction of α,β-unsaturated aldehydes with hydrazine and subsequent dehydrogenation. 2075-46-9, formula is C3H3N3O2, Name is 4-Nitro-1H-pyrazole. Substituted pyrazoles are prepared by condensation of 1,3-diketones with hydrazine (Knorr-type reactions). For example, acetylacetone and hydrazine gives 3,5-dimethylpyrazole. Recommanded Product: 4-Nitro-1H-pyrazole.

Liu, Yong-zheng;Guo, Heng-jie research published 《 Solubility determination and crystallization thermodynamics of an intermediate in different organic solvents》, the research content is summarized as follows. This study reported the solid-liquid equilibrium solubility of 4-nitropyrazole at the temperature ranging 288.15 K to 328.15 K in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, isobutanol, 1-pentanol, isoamyl alc., acetonitrile, acetone, Me acetate, Et acetate, THF and water, resp. All the experiments were performed with the gravimetric method under the ambient pressure of 0.1 MPa. At the temperature ranging from 288.15 K to 328.15 K, 4-nitropyrazole in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, isobutanol, 1-pentanol, isoamyl alc., acetonitrile, acetone, Me acetate, Et acetate, THF and water exhibited the mole fraction solubility values of 0.109034-0.365964, 0.101321-0.310165, 0.087146-0.312564, 0.048152-0.238024, 0.079024-0.282653, 0.054890-0.247235, 0.071382-0.275687, 0.062864-0.21521, 0.039062-0.135087, 0.038140-0.058187, 0.007271-0.027222, 0.004829-026068, 0.004126-0.021975 and 0.002174-0.015095, resp. The acquired solubility data of 4-nitropyrazole in the selected solvents was correlated with the modified Apelblat equation, λh equation, the ideal equation, as well as the polynomial empirical equation. Next, the correlated values of the four equations were significantly consistent with the experiment values, and the polynomial empirical equation yielded more effective correlated results than other equations. In addition, the solvent effect on 4-nitropyrazole solubility was investigated with Kamlet-Taft parameters. Moreover, to clarify the sequence of solubility in a range of solvents, the mol. modeling studies were conducted. Activity coefficient was to access the solute-solvent mol. interactions. Furthermore, the thermodn. properties exhibited by 4-nitropyrazole (i.e., standard dissolution enthalpy (ΔdisHo), standard dissolution entropy (ΔdisSo) and standard dissolution Gibbs free energy (ΔdisGo)) in the selected solvents were characterized and then discussed from the experiment data. Besides, ΔdisHo, ΔdisSo and ΔdisGo at mean temperature in different pure solvents reached 22.40 kJ·mol^-1-38.07 kJ·mol^-1, 58.21 J·K^-1·mol^-1-81.10 J·K^-1·mol^-1 and 4.20 kJ·mol^-1-13.13 kJ·mol^-1, resp. As revealed from the result, 4-nitropyrazole in solvents selected showed a non-spontaneous and entropy-driven dissolution The present study could present the fundamental data to sep. 4-nitropyrazole.

Recommanded Product: 4-Nitro-1H-pyrazole, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g/mol. The purity is usually 95%.

4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson’s disease., 2075-46-9.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazoles are synthesized by the reaction of α,β-unsaturated aldehydes with hydrazine and subsequent dehydrogenation. 37622-90-5, formula is C6H8N2O2, Name is Ethyl 4-pyrazolecarboxylate. Substituted pyrazoles are prepared by condensation of 1,3-diketones with hydrazine (Knorr-type reactions). For example, acetylacetone and hydrazine gives 3,5-dimethylpyrazole. Computed Properties of 37622-90-5.

Liu, Wen-Xing;Yang, Zhusheng;Qiao, Zhi;Zhang, Long;Zhao, Ning;Luo, Sanzhong;Xu, Jian research published 《 Dynamic multiphase semi-crystalline polymers based on thermally reversible pyrazole-urea bonds》, the research content is summarized as follows. Constructing responsive and adaptive materials by dynamic covalent bonds is an attractive strategy in material design. Here, we present a kind of dynamic covalent polyureas which can be prepared from the highly efficient polyaddition reaction of pyrazoles and diisocyanates at ambient temperature in the absence of a catalyst. Owing to multiphase structural design, poly(pyrazole-ureas) (PPzUs) show excellent mech. properties and unique crystallization behavior. Besides, the crosslinked PPzUs can be successfully recycled upon heating (∼130°C) and the mol.-level blending of polyurea and polyurethane is realized. Theor. studies prove that the reversibility of pyrazole-urea bonds (PzUBs) arises from the unique aromatic nature of pyrazole and the N-assisting intramol. hydrogen transfer process. The PzUBs could further broaden the scope of dynamic covalent bonds and are very promising in the fields of dynamic materials.

Computed Properties of 37622-90-5, Ethyl 4-pyrazolecarboxylate, also known as Ethyl pyrazole-4-carboxylate, is a useful research compound. Its molecular formula is C6H8N2O2 and its molecular weight is 140.14 g/mol. The purity is usually 95%.

Ethyl pyrazole-4-carboxylate is a low yield, transition metal salt that is used in the synthesis of pyrazoles. It can be synthesized by the reaction of sodium ethoxide with ethyl chloroformate and a Grignard reagent. Sodium ethoxide is added to a suspension of sodium chloride and dried ethyl chloroformate, followed by addition of magnesium turnings. The mixture is refluxed for one hour, cooled, and filtered to give crystals. Ethyl pyrazole-4-carboxylate is used in the preparation of ethyl esters from aliphatic alcohols by reacting with boron trichloride or phosphorus pentachloride. It participates in certain chemical reactions as a byproduct and can damage equipment during chemical reactions. The yield of this compound can be increased by using an excess amount of Grignard reagent or adding hexamethylenetetramine to the reaction mixture, 37622-90-5.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazole is an organic compound with the formula C3H3N2H. It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms, which are in ortho-substitution. 2075-46-9, formula is C3H3N3O2, Name is 4-Nitro-1H-pyrazole. Pyrazoles are a class of compounds that have the ring C3N2 with adjacent nitrogen atoms.Notable drugs containing a pyrazole ring are celecoxib (celebrex) and the anabolic steroid stanozolol. HPLC of Formula: 2075-46-9.

Liu, Wen-dong;Li, Yong-xiang;Cao, Duan-lin;Li, Zi-yang research published 《 Solubility and thermodynamic properties of an energetic intermediate in four binary solvents (water + n-butanol, n-pentanol, isobutanol and isoamyl alcohol)》, the research content is summarized as follows. The solubility of 4-nitropyrazole (4-NP) in four different binary solvents (i.e., water + n-butanol, water + n-pentanol, water + isobutanol, and water + isoamyl alc.) was firstly determined by a gravimetric method within a temperature range of 288.15 K to 328.15 K at atm. pressure (P = 0.1 MPa). The exptl. results indicated that the solubility of 4-NP in selected binary solvents increases with the increasing temperature and decreases with the rising water mass-fraction ranging. Besides, the (solid + liquid) equilibrium values in the studied solvents were correlated based on the modified Apelblat equation, Jouyban-Acree model, CNIBS/R-K model, and Wilson model. Moreover, all of the 324 exptl. values were used to correlate the parameters of the Wilson model, and the correlated results were superior to the other three models by comparing the average 10⁴RMSD and R². The average root-mean-square deviation (10⁴RMSD) values were 1.87, 31.83, 6.04, and 1.18, resp. In addition, Hansen solubility parameters were employed to provide a reasonable illustration for the solubility order of 4-NP in the 4 binary mixed solvents, and the order of 4-NP solubility in each binary solvent mixture was the result of the combined effects of hydrogen bonding, dispersion, and polarity. Furthermore, the Wilson model was applied to calculate the thermodn. properties of 4-NP including mixing enthalpy, mixing entropy, and mixing free Gibbs energy in the studied binary solvent mixtures at a given temperature It is easy to understand that dissolution is an exothermic process from the results. Solid-liquid surface tension (γ) and surface entropy factor (f) of 4-NP were estimated by using the exptl. solubility data, and the results showed that γ and f increase with the increasing mass-fraction of water content in the binary mixed solvent and decrease with the increasing temperature The exptl. solubility values, model parameters, and thermodn. properties of 4-NP in different mixed solvents will provide the necessary support for its preparation, crystallization process, and further theor. studies.

2075-46-9, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g/mol. The purity is usually 95%.

4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson’s disease., HPLC of Formula: 2075-46-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazoles are synthesized by the reaction of α,β-unsaturated aldehydes with hydrazine and subsequent dehydrogenation. 37622-90-5, formula is C6H8N2O2, Name is Ethyl 4-pyrazolecarboxylate. Substituted pyrazoles are prepared by condensation of 1,3-diketones with hydrazine (Knorr-type reactions). For example, acetylacetone and hydrazine gives 3,5-dimethylpyrazole. SDS of cas: 37622-90-5.

Liu, Shaohua;He, Peixin;Tian, Zhaofu;Li, Xiaolan;Xu, Chunping research published 《 Ultrasound-assisted extraction and characterization of polysaccharide from Maryland tobacco leaves》, the research content is summarized as follows. Ultrasound-assisted extraction (UAE) of polysaccharide from Maryland tobacco leaves was studied by response surface methodol. Furthermore, the crude polysaccharide was purified and two components (Fr-I and Fr-II) were obtained. FT-IR spectral anal. of the purified polysaccharide revealed prominent characteristic groups. The monosaccharide composition anal. by gas chromatog.-mass spectrometry (GC/MS) indicated the main composition between Fr-I and Fr-II was different. Furthermore, thermo gravimetric anal. (TGA) indicated the degradation temperature (Td) of the Fr-I (241 °C) was higher than those of Fr-II (216 °C). Detected by the pyrolysis gas chromatog.-mass spectrometry (py-GC/MS), it was found that the main kinds of pyrolysis products from both Fr-I and Fr-II were similar. Finally, On the basis of hydroxyl and DPPH radical scavenging assay, Fr-II has stronger antioxidant activities than Fr-I. The thermal behavior and antioxidant activity might be attributed to the configuration of the chem. compositions

SDS of cas: 37622-90-5, Ethyl 4-pyrazolecarboxylate, also known as Ethyl pyrazole-4-carboxylate, is a useful research compound. Its molecular formula is C6H8N2O2 and its molecular weight is 140.14 g/mol. The purity is usually 95%.

Ethyl pyrazole-4-carboxylate is a low yield, transition metal salt that is used in the synthesis of pyrazoles. It can be synthesized by the reaction of sodium ethoxide with ethyl chloroformate and a Grignard reagent. Sodium ethoxide is added to a suspension of sodium chloride and dried ethyl chloroformate, followed by addition of magnesium turnings. The mixture is refluxed for one hour, cooled, and filtered to give crystals. Ethyl pyrazole-4-carboxylate is used in the preparation of ethyl esters from aliphatic alcohols by reacting with boron trichloride or phosphorus pentachloride. It participates in certain chemical reactions as a byproduct and can damage equipment during chemical reactions. The yield of this compound can be increased by using an excess amount of Grignard reagent or adding hexamethylenetetramine to the reaction mixture, 37622-90-5.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns. 269410-08-4, formula is C9H15BN2O2, Name is 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. 1-Methyl-5-(trifluoromethyl)pyrazole underwent deprotonation and subsequent carboxylation mainly or exclusively at either the 4-position of the heterocycle or at the nitrogen-attached methyl group. Safety of 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole.

Liu, Kevin G.;Kim, Ji-In;Olszewski, Kellen;Barsotti, Anthony M.;Morris, Koi;Lamarque, Christophe;Yu, Xuemei;Gaffney, Jack;Feng, Xiao-Jiang;Patel, Jeegar P.;Poyurovsky, Masha V. research published 《 Discovery and Optimization of Glucose Uptake Inhibitors》, the research content is summarized as follows. Aerobic glycolysis, originally identified by Warburg as a hallmark of cancer, has recently been implicated in immune cell activation and growth. Glucose, the starting material for glycolysis, is transported through the cellular membrane by a family of glucose transporters (GLUTs). Therefore, targeting glucose transporters to regulate aerobic glycolysis is an attractive approach to identify potential therapeutic agents for cancers and autoimmune diseases. Herein, we describe the discovery and optimization of a class of potent, orally bioavailable inhibitors of glucose transporters, targeting both GLUT1 and GLUT3.

Safety of 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, also known as 4-Pyrazoleboronic acid pinacol ester , is a useful research compound. Its molecular formula is C9H15BN2O2 and its molecular weight is 194.04 g/mol. The purity is usually 95%.

4-Pyrazoleboronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. 4-Pyrazoleboronic acid pinacol ester is also a useful reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors.

4-Pyrazoleboronic acid pinacol ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.

4-Pyrazoleboronic acid pinacol ester is an organic compound that is the product of a bifunctional coupling reaction between 4-pyrazolecarboxylic acid and pinacol. It has been shown to inhibit protein S6 kinase, which is involved in the regulation of cell growth and proliferation. This compound has also been shown to be effective against cancer cells, including those that are resistant to conventional chemotherapeutic drugs. 4-Pyrazoleboronic acid pinacol ester may also be used as a precursor for other compounds with pharmaceutical activity., 269410-08-4.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazoles and pyrimidines have diverse biological and pharmacological activities. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Product Details of C10H17BN2O2.

Liu, Dandan;Ge, Huan;Xu, Fangling;Xu, Yufang;Liu, Wenjun;Li, Honglin;Zhu, Lili;Diao, Yanyan;Zhao, Zhenjiang research published 《 Design, synthesis and SAR study of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors》, the research content is summarized as follows. The abnormal activation of JAK2 kinase is closely related to the occurrence and progression of myeloproliferative neoplasms (MPNs). At present, there is still an obvious unmet medical need for selective JAK2 inhibitors in clinic. In this paper, a class of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors was obtained by combining drug design, synthesis and structure-activity relationship studies based on the previously identified lead Crizotinib. Among them, I exhibited high inhibitory activity against JAK2 with an IC₅₀ of 9 9 nmol/L, moreover, it showed 276- and 184-fold selectivity over JAK1 and JAK3, resp. Besides, I had a significant antiproliferative activity against HEL cells, and also inhibited the phosphorylation of JAK2 and its down-stream signaling pathway. These results indicated that 2-aminopyridine compound I had the potential to be developed as a selective JAK2 inhibitor for further study.

761446-44-0, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., Product Details of C10H17BN2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazole is an organic compound with the formula C3H3N2H. It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms, which are in ortho-substitution. 269410-08-4, formula is C9H15BN2O2, Name is 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Pyrazoles are a class of compounds that have the ring C3N2 with adjacent nitrogen atoms.Notable drugs containing a pyrazole ring are celecoxib (celebrex) and the anabolic steroid stanozolol. Name: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole.

Liu, Dandan;Ge, Huan;Xu, Fangling;Xu, Yufang;Liu, Wenjun;Li, Honglin;Zhu, Lili;Diao, Yanyan;Zhao, Zhenjiang research published 《 Design, synthesis and SAR study of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors》, the research content is summarized as follows. The abnormal activation of JAK2 kinase is closely related to the occurrence and progression of myeloproliferative neoplasms (MPNs). At present, there is still an obvious unmet medical need for selective JAK2 inhibitors in clinic. In this paper, a class of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors was obtained by combining drug design, synthesis and structure-activity relationship studies based on the previously identified lead Crizotinib. Among them, I exhibited high inhibitory activity against JAK2 with an IC₅₀ of 9 9 nmol/L, moreover, it showed 276- and 184-fold selectivity over JAK1 and JAK3, resp. Besides, I had a significant antiproliferative activity against HEL cells, and also inhibited the phosphorylation of JAK2 and its down-stream signaling pathway. These results indicated that 2-aminopyridine compound I had the potential to be developed as a selective JAK2 inhibitor for further study.

Name: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, also known as 4-Pyrazoleboronic acid pinacol ester , is a useful research compound. Its molecular formula is C9H15BN2O2 and its molecular weight is 194.04 g/mol. The purity is usually 95%.

4-Pyrazoleboronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. 4-Pyrazoleboronic acid pinacol ester is also a useful reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors.

4-Pyrazoleboronic acid pinacol ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.

4-Pyrazoleboronic acid pinacol ester is an organic compound that is the product of a bifunctional coupling reaction between 4-pyrazolecarboxylic acid and pinacol. It has been shown to inhibit protein S6 kinase, which is involved in the regulation of cell growth and proliferation. This compound has also been shown to be effective against cancer cells, including those that are resistant to conventional chemotherapeutic drugs. 4-Pyrazoleboronic acid pinacol ester may also be used as a precursor for other compounds with pharmaceutical activity., 269410-08-4.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics