Day: October 18, 2022

Ward, D. D.; Grimmett, M. R. published the artcile< Separation of pyrazoles by gas chromatography>, Name: 4-Bromo-3-phenyl-1H-pyrazole, the main research area is pyrazole separation gas chromatog.

Pyrazole derivatives were separated by gas chromatog. by using glass columns (2.5 m × 1.5 mm) packed with silanized Chromosorb W (100-200 mesh) coated with 12% OV-17 or OV-225, N carrier gas at 20-25 cm3-min, inlet temperature 130-40°, a flame ionization detector at 300-50°, and temperature programming from 50° at 10°/min. Relative retention indexes and linear programmed indexes are given for alkyl-, 4-bromo-, 1-nitro-, C-nitro-, and bromonitropyrazoles. Although both N-substituted and N-unsubstituted pyrazoles could be separated on the same columns, 1-nitropyrazoles were sometimes susceptible to denitration at the higher temperatures used.

Journal of Chromatography published new progress about Gas chromatography. 13808-65-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Name: 4-Bromo-3-phenyl-1H-pyrazole.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kline, Mike; Cheatham, Steve published the artcile< A robust method for determining 1H-15N long-range correlations: 15N optimized CIGAR-HMBC experiments>, Name: 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine, the main research area is amine hydrogen nitrogen optimized CIGAR HMBC; nitrogen heterocycle optimized CIGAR HMBC.

An examination of a variety of common N-containing systems was undertaken to optimize parameters for observation of 1H-15N long-range correlations. Because of the diversity of coupling constants encountered with 1H-15N correlations, a modified accordion-based sequence was used to provide the best results. Optimization of the values for the accordion delay revealed that a range between 3 and 10 Hz provided the best compromise between detection of weak correlations and loss of signal to T2 processes. Multiple bond correlations were readily detected for each class of compound with the exception of anilines. Correlations within heterocyclic systems revealed some general patterns. In general, stronger correlations were observed from protons to pyrrole-like nitrogens than to the pyridine-type nitrogens of imidazoles and pyrazoles. Very long-range (four- and five-bond) correlations were routinely observed between Me groups and the nitrogens of aromatic heterocycles.

Magnetic Resonance in Chemistry published new progress about Amines Role: PRP (Properties). 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, Name: 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Marin-Luna, Marta; Claramunt, Rosa M.; Lopez, Concepcion; Perez-Torralba, Marta; Sanz, Dionisia; Reviriego, Felipe; Alkorta, Ibon; Elguero, Jose published the artcile< A GIPAW versus GIAO-ZORA-SO study of 13C and 15N CPMAS NMR chemical shifts of aromatic and heterocyclic bromo derivatives>, HPLC of Formula: 13808-65-6, the main research area is bromo heterocycle CPMAS NMR chem shift shielding IR spectra; GIAO; GIPAW; HALA; Heterocyclic compounds; NMR crystallography; ZORA.

We reported herein the theor. characterization of 13C and 15N CPMAS NMR of known bromo-derivative crystals by using both the GIPAW and the combined GIAO-ZORA-SO approximation methods. Several statistical analyses were performed to compare both approaches, with non-relativistic GIPAW method being more useful to predict the 13C and 15N chem. shifts. The problem of applying GIPAW to crystal structures showing static or dynamic crystalline disorder of the special class resulting in half-protons will be discussed in detail.

Solid State Nuclear Magnetic Resonance published new progress about Azoles Role: PRP (Properties). 13808-65-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, HPLC of Formula: 13808-65-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

He, Yuanjun; Duckett, Derek; Chen, Weimin; Ling, Yuan Yuan; Cameron, Michael D.; Lin, Li; Ruiz, Claudia H.; LoGrasso, Philip V.; Kamenecka, Theodore M.; Koenig, Marcel published the artcile< Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors>, Computed Properties of 936250-20-3, the main research area is pyridylisoxazole preparation JNK inhibitor SAR selectivity p38; Isoxazole; JNK; Kinase; c-Jun.

The design and synthesis of isoxazole I is described, a potent JNK inhibitor with two fold selectivity over p38. Optimization of this scaffold led to compounds II and III which showed greatly improved selectivity over p38 by maintaining the JNK3 potency of compound I. Extensive SAR studies will be described as well as preliminary in vivo data of the two lead compounds

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 936250-20-3 belongs to class pyrazoles-derivatives, and the molecular formula is C10H17BN2O2, Computed Properties of 936250-20-3.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics