Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns. 2075-46-9, formula is C3H3N3O2, Name is 4-Nitro-1H-pyrazole. 1-Methyl-5-(trifluoromethyl)pyrazole underwent deprotonation and subsequent carboxylation mainly or exclusively at either the 4-position of the heterocycle or at the nitrogen-attached methyl group. Recommanded Product: 4-Nitro-1H-pyrazole.
Barzegar-Jalali, Mohammad;Rahimpour, Elaheh;Martinez, Fleming;Jouyban, Abolghasem research published 《 Generally trained models to predict drug solubility in methanol + water mixtures》, the research content is summarized as follows. The aim of this study is to develop the trained versions of Yalkowsky and Jouyban-Acree models for the prediction of drug solubility in the binary aqueous mixtures of methanol (MeOH) at various temperatures To provide a full predictive model, the Abraham solvation parameters of solutes are combined with the proposed models. The solubility data of 41 drug and/or drug-like compounds with different polarities and structural features covering the total drug-like space are fitted by these models. The generally trained models provide reasonable estimation of the solubility behavior of drugs and can be helpful in the pharmaceutical industry.
Recommanded Product: 4-Nitro-1H-pyrazole, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g/mol. The purity is usually 95%.
4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson’s disease., 2075-46-9.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics