Day: April 18, 2022

Application of 1300746-79-5. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). Author is Rai, Ganesha; Brimacombe, Kyle R.; Mott, Bryan T.; Urban, Daniel J.; Hu, Xin; Yang, Shyh-Ming; Lee, Tobie D.; Cheff, Dorian M.; Kouznetsova, Jennifer; Benavides, Gloria A.; Pohida, Katie; Kuenstner, Eric J.; Luci, Diane K.; Lukacs, Christine M.; Davies, Douglas R.; Dranow, David M.; Zhu, Hu; Sulikowski, Gary; Moore, William J.; Stott, Gordon M.; Flint, Andrew J.; Hall, Matthew D.; Darley-Usmar, Victor M.; Neckers, Leonard M.; Dang, Chi V.; Waterson, Alex G.; Simeonov, Anton; Jadhav, Ajit; Maloney, David J..

The authors report the discovery and medicinal chem. optimization of a novel series of pyrazole-based inhibitors of human lactate dehydrogenase (LDH). Utilization of a quant. high-throughput screening paradigm facilitated hit identification, while structure-based design and multiparameter optimization enabled the development of compounds with potent enzymic and cell-based inhibition of LDH enzymic activity. Lead compounds such as 63 exhibit low nM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate production, and inhibition of glycolysis in MiaPaCa2 pancreatic cancer and A673 sarcoma cells. Moreover, robust target engagement of LDHA by lead compounds was demonstrated using the cellular thermal shift assay (CETSA), and drug-target residence time was determined via SPR. Anal. of these data suggests that drug-target residence time (off-rate) may be an important attribute to consider for obtaining potent cell-based inhibition of this cancer metabolism target.

After consulting a lot of data, we found that this compound(1300746-79-5)Application of 1300746-79-5 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Computed Properties of C13H23NO4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-tert-Butyl 2-ethyl piperidine-1,2-dicarboxylate, is researched, Molecular C13H23NO4, CAS is 362703-48-8, about New short and general synthesis of three key Maillard flavour compounds: 2-Acetyl-1-pyrroline, 6-acetyl-1,2,3,4-tetrahydropyridine and 5-acetyl-2,3-dihydro-4H-1,4-thiazine. Author is Deblander, Jurgen; Van Aeken, Sam; Adams, An; De Kimpe, Norbert; Abbaspour Tehrani, Kourosch.

A general synthetic route was developed to obtain 3 key Maillard flavor compounds, namely 2-acetyl-1-pyrroline, 6-acetyl-1,2,3,4-tetrahydropyridine, and 5-acetyl-2,3-dihydro-4H-1,4-thiazine. The key step in the process is the methylenation reaction of azaheterocyclic carboxylic esters by dimethyltitanocene, giving rise to intermediate vinyl ethers which can be considered stable precursors for the title compounds Simple acidic treatment of these precursors can release the characteristic Maillard flavor compounds

After consulting a lot of data, we found that this compound(362703-48-8)Computed Properties of C13H23NO4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: 17190-29-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Efficient lipase-catalyzed kinetic resolution and dynamic kinetic resolution of β-hydroxy nitriles. A route to useful precursors for γ-amino alcohols. Author is Pamies, Oscar; Backvall, Jan-E..

An efficient kinetic resolution of racemic β-hydroxy nitriles was performed via Candida antarctica lipase (N-435)-catalyzed transesterification. A variety of racemic alkyl, aryl, and aryloxymethyl substituted β-hydroxy nitriles was efficiently transformed to the corresponding enantiomerically pure acetates (ee >99% and conversion = 50%) with E values from 40 to >1000. The combination of the enzymic kinetic resolution with a ruthenium-catalyzed alc. racemization led to a dynamic kinetic resolution (ee’s up to 99%, yields up to 85%).

After consulting a lot of data, we found that this compound(17190-29-3)HPLC of Formula: 17190-29-3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Category: pyrazoles-derivatives. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Development and validation of the HPLC-DAD method for the quantification of 16 synthetic dyes in various foods and the use of liquid anion exchange extraction for qualitative expression determination.

Synthetic dyes can cause many health problems, and their use as food additives is rigorously regulated worldwide. Two methods for the determination of synthetic dyes in food are described in this article. The visual qual. expression method was based on the extraction of synthetic dyes using a liquid anion exchanger (0.01 M solution of trioctylmethylammonium chloride in chloroform). Using this reagent, an optimal transition of 15 anionic synthetic dyes from the aqueous to the organic phase was achieved (R > 99.8%). It was applicable for testing food that must not contain synthetic dyes (wines, juices, etc.) in a very short time (5-10 min). In the case of coloring of the organic phase, identification and quantification was carried out using the HPLC-DAD method described. The rapid and simple method allows for simultaneous determination of 16 synthetic dyes from all food types. The LOD and LOQ ranged from 0.026 to 0.086μg mL-1 and from 0.077 to 0.262μg mL-1 resp., and recovery was 83.7-107.5%. Hypothesis: anionic synthetic dyes have hydrophobic properties, as a result they are retained on the non-polar stationary phase of the chromatog. column and are easily extracted from aqueous solutions by liquid anion exchangers.

After consulting a lot of data, we found that this compound(25956-17-6)Category: pyrazoles-derivatives can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Walther, Martin; Matterna, Madlen; Juran, Stefanie; Faehnemann, Silke; Stephan, Holger; Kraus, Werner; Emmerling, Franziska published the article 《Imidazole-containing bispidine ligands: synthesis, structure and Cu(II) complexation》. Keywords: copper imidazole bispidine complex preparation crystal structure.They researched the compound: (1H-Imidazol-2-yl)methanamine dihydrochloride( cas:22600-77-7 ).Category: pyrazoles-derivatives. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:22600-77-7) here.

The preparation and characterization of tris-pyridyl bispidine (3,7-diazabicyclo[3.3.1]nonane) derivatives with benzimidazole and imidazole donor groups at the N-3 position of the bispidine skeleton and their copper(II) complexes are reported. The impact of the hetaryl substituents on the configurational isomerism of piperidones and their corresponding bispidones was studied by NMR spectroscopy, revealing the exclusive appearance in the enol form for the piperidones in solution and the trans-configuration regarding the two pyridyl substituents, as well as the sole formation of the unsym. exo-endo isomers for the corresponding bispidones. Thus, the bispidones are preorganized ligands for building pentacoordinated complexes, confirmed by the preparation and characterization of the corresponding Cu(II) complexes. Of the di-pyridyl piperidones with benzimidazole and imidazole substituents, and of the Cu(II) complex of the benzimidazole-containing bispidone, crystals have become available for the anal. by x-ray diffraction, showing that the piperidones form the enol tautomers also in the solid state.

After consulting a lot of data, we found that this compound(22600-77-7)Category: pyrazoles-derivatives can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics