Day: April 15, 2022

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 17190-29-3, is researched, Molecular C9H9NO, about Direct Catalytic Aldol-Type Reactions Using RCH2CN, the main research direction is beta hydroxynitrile preparation; copper catalyst trimethylsilylacetonitrile alkyl nitrile aldehyde ketone; phosphine ligand copper catalyzed addition alkyl nitrile aldehyde ketone; triethoxysilyl fluoride reagent copper catalyzed addition trimethylsilylacetonitrile aldehyde ketone; enantioselective addition acetonitrile trimethylsilylacetonitrile aldehyde copper catalyst nonracemic binaphthylphosphine; direct catalytic aldol addition reaction nitrile.Synthetic Route of C9H9NO.

β-Hydroxynitriles are prepared from either trimethylsilylacetonitrile or from alkyl nitriles in the presence of copper catalysts; in the presence of nonracemic ligands, the copper-catalyzed addition of acetonitrile or trimethylsilylacetonitrile yields nonracemic β-hydroxynitriles in moderate enantioselectivities and yields. α-Unsubstituted-β-hydroxynitriles are prepared in 75-100% yields by the addition of trimethylsilylacetonitrile to aldehydes and ketones in the presence of copper fluoride and a stoichiometric quantity of triethoxysilyl fluoride; the reaction is effective for aryl ketones and aldehydes, alkyl and cycloalkyl aldehydes, and α,β-unsaturated aldehydes and ketones. α-Unsubstituted- and α-substituted-β-hydroxynitriles are prepared in 71-95% yields by the addition of alkyl nitriles RCH2CN (R = H, Me, Et) to aldehydes in the presence of alk. metal-free copper (I) tert-butoxide (generated by addition of tert-butanol to mesitylcopper) and a phosphine such as dppe; α-substituted-β-hydroxynitriles are generated with moderate to low stereoselectivities for the syn isomers. Hydrolysis of the nitriles to carboxylic acids with base allows the addition of nitriles to aldehydes and ketones to function as a catalytic surrogate for the aldol addition reaction of esters to ketones and aldehydes. In the presence of nonracemic diphosphine ligands and either copper (I) tert-butoxide or copper (I) fluoride and triethoxysilyl fluoride, either acetonitrile or trimethylsilylacetonitrile, resp., add enantioselectively to aldehydes or ketones to give β-hydroxynitriles in 48-70% yields and in 47-53% ee.

After consulting a lot of data, we found that this compound(17190-29-3)Synthetic Route of C9H9NO can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Fluoro-1H-indole-3-carboxylic acid, is researched, Molecular C9H6FNO2, CAS is 23077-42-1, about Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure-Activity Relationships and Membrane Targeting Properties, the main research direction is antimycobacterial membrane targeting indole preparation structure activity.Formula: C9H6FNO2.

Antibacterials that disrupt cell membrane function have the potential to eradicate “”persister”” organisms and delay the emergence of resistance. Here we report the antimycobacterial activities of 4-fluoro and 6-methoxyindoles bearing a cationic amphiphilic motif represented by a lipophilic n-octyl side chain at position 1 and a pos. charged azepanyl or 1,4-dioxa-8-azaspiro[4.5]decane moiety at position 3. These analogs exhibited balanced profiles of potency (Mycobacterium bovis BCG, M tuberculosis H37Rv), selective activity, solubility, and metabolic stability. Bacteriol. mechanism of action investigations on a representative analog revealed cell membrane permeabilization and depolarization in M bovis BCG. These membrane-related changes preceded cell death indicating that the loss in membrane integrity was not an epiphenomenon. Bactericidal activity was observed against both growing and nongrowing mycobacterial cultures. The analog also upregulated cell envelope stress-inducible promoters piniBAC and pclgR, implicating the involvement of envelope-related targets in its mode of action.

After consulting a lot of data, we found that this compound(23077-42-1)Formula: C9H6FNO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Quality Control of Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Using High-Throughput Screening to Evaluate Perturbations Potentially Linked to Neurobehavioral Outcomes: A Case Study Using Publicly Available Tools on FDA Batch-Certified Synthetic Food Dyes. Author is Pham, Nathalie; Miller, Mark D.; Marty, Melanie.

There is growing evidence from human and animal studies indicating an association between exposure to synthetic food dyes and adverse neurobehavioral outcomes in children. However, data gaps persist for potential mechanisms by which the synthetic food dyes could elicit neurobehavioral impacts. We developed an approach to evaluate seven US FDA-batch-certified food dyes using publicly available high-throughput screening (HTS) data from the US EPA’s Toxicity Forecaster to assess potential underlying mol. mechanisms that may be linked to neurol. pathway perturbations. The dyes were screened through 270 assays identified based on whether they had a neurol.-related gene target and/or were mapped to neurodevelopmental processes or neurobehavioral outcomes, and were conducted in brain tissue, targeted specific hormone receptors, or targeted oxidative stress and inflammation. Some results provided support for neurol. impacts found in human and animal studies, while other results showed a lack of correlation with in vivo findings. The azo dyes had a range of activity in assays mapped to G-protein-coupled receptors and were active in assays targeting dopaminergic, serotonergic, and opioid receptors. Assays mapped to nuclear receptors (androgen, estrogen, and thyroid hormone) also exhibited activity with the food dyes. Other mol. targets included the aryl hydrocarbon receptor, acetylcholinesterase, and monoamine oxidase. The Toxicol. Prioritization Index tool was used to visualize the results of the Novascreen assays. Our results highlight certain limitations of HTS assays but provide insight into potential underlying mechanisms of neurobehavioral effects observed in in vivo animal toxicol. studies and human clin. studies.

After consulting a lot of data, we found that this compound(25956-17-6)Quality Control of Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 25956-17-6, is researched, Molecular C18H14N2Na2O8S2, about Modeling of fixed-bed dye adsorption using response surface methodology and artificial neural network, the main research direction is modeling fixed bed polyurethane chitosan foam adsorption red dye; artificial neural network modeling dye foam adsorption red dye; response surface methodol modeling red 40 dye adsorption; adsorption wastewater treatment red 40 dye polyurethane chitosan foam.Recommanded Product: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate.

Artificial neural network (ANN) and response surface methodol. (RSM) models were used to analyze the fixed bed adsorption of food, drug, and cosmetic (FD&C) red 40 dye by polyurethane/chitosan foam (PU/CS foam). The adsorbent was prepared and characterized. The effect of process variables (flow rate, bed height) were examined on two levels by RSM. Break-through curves were used as a training dataset for ANN. ANN was customized with 10 neurons in the hidden layer using the hyperbolic tangent sigmoid transfer function as activation function and the linear transfer function in the output layer. The optimal range of bed operation was 5-6 cm bed height and 15-17.05 mL/min flow rate. Column exptl. adsorption capacity values were 44.3-108.1 mg/g, and were compared with ANN and RSM modeling results. ANN predicted exptl. data with greater accuracy than RSM. Coefficient of determination values were 0.9911 for ANN and 0.8853 for RSM. Various error functions tested for ANN and RSM model-predicted and exptl. values demonstrated the better applicability and efficiency of the ANN model. PU/CS foam proved a promising, low cost adsorbent with excellent potential to remove FD&C red 40.

After consulting a lot of data, we found that this compound(25956-17-6)Recommanded Product: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mejia-Otalvaro, Felipe; Merino-Restrepo, Andres; Hormaza-Anaguano, Angelina researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).Related Products of 25956-17-6.They published the article 《Evaluation of a Trametes pubescens laccase concentrated extract on allura red AC decolorization without the addition of synthetic mediators》 about this compound( cas:25956-17-6 ) in Journal of Environmental Management. Keywords: Trametes laccase allura red AC decolorization wastewater treatment; Bioremediation; Dye decolorization; Immobilization; Ligninolytic enzymes; White-rot fungi. We’ll tell you more about this compound (cas:25956-17-6).

Synthetic dye bioremediation is a topic of great importance since these pollutants possess toxic effects, and huge quantities of them are being discharged into water bodies. Ligninolytic enzyme treatment stands out for being a cost-effective methodol., capable of obtaining high decolorization levels. In this work, a laccase enzyme treatment was evaluated to effectively perform a cycle of dye bioremediation. Furthermore, a dye decolorization improvement was also assessed through laccase immobilization. Particularly, a Trametes pubescens enzyme extract was concentrated, immobilized onto calcium alginate beads, and characterized to assess its dye decolorization potential. Ammonium sulfate precipitation and vacuum evaporation were evaluated to concentrate the crude extract and to decolorize allura red AC. Both treatments reached a high enzyme yield recovery (>90%), but only the vacuum-evaporated extract achieved a high allura red AC decolorization level after 16 h of contact time. This suggested that essential compounds for allura red AC decolorization were present in the crude extract, implying that neither a complete laccase purification process nor an addition of synthetic mediators are necessary. Under optimized immobilization conditions, 94.6% immobilization efficiency and 49.8% activity recovery were obtained with 0:1 alginate:enzyme (volume/volume), 100 mM CaCl2, and 5.0% w/v sodium alginate. Furthermore, by immobilizing the laccase concentrated extract, both the pH and temperature stabilities were improved. The decolorization of allura red AC by free and immobilized laccase was 68.4% and 4.6%, resp., showing that although the enzyme stability was improved, dye decolorization was neg. affected. Thus, an efficient allura red AC decolorization was obtained with concentrated-free laccase by a feasible and low-cost methodol.

After consulting a lot of data, we found that this compound(25956-17-6)Related Products of 25956-17-6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Computed Properties of C8H7BrO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about Rhodium-Catalyzed Direct Arylation of Furopyridine: Synthesis and the Cardiac Effects of Dictamnine Derivatives. Author is Du, Yufeng; Huang, Linyu; Wang, Neng; Li, Xiaohuan; Zhou, Xian-Li; Zhang, Lan; Huang, Shuai; Walsh, Patrick J.; Gao, Feng.

Synthesis of Rh2(OAc)4/IMes·HCl system promotes the chemoselective installation of aryl groups at the 2-position of furo[2,3-b]pyridines I (R = Ph, naphthalen-1-yl, 2,3-dihydro-1,4-benzodioxin-6-yl, etc.) (53-94% yields). The method is applicable to the direct modification of the natural furoquinoline alkaloid dictamnine. The cardiac effects of the fluorinated analogs II were improved, and compared to dictamnine at 160 μg/mL. Preliminary mechanism of action studies indicate that the effects might be related to epinephrine αreceptors, M-receptor and calcium channel receptor.

After consulting a lot of data, we found that this compound(52287-51-1)Computed Properties of C8H7BrO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zorina, L. N.; Safiev, O. G.; Chanyshev, R. R.; Zorin, V. V.; Rakhmankulov, D. L. published the article 《Preparation of halogenated benzodioxacycloalkanes》. Keywords: benzodioxole sodium hypochlorite halogenation; benzodioxan sodium hypobromite halogenation; halobenzodioxole preparation; halobenzodioxan preparation.They researched the compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine( cas:52287-51-1 ).Recommanded Product: 52287-51-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:52287-51-1) here.

Reaction of 1,3-benzodioxole (I) and 1,4-benzodioxan (II) with NaOCl and NaOBr in presence of sulfuric acid resulted in mono- and dihalogenated derivatives of I and II. Regioselectivity of this reaction depended on the reagents ratio.

After consulting a lot of data, we found that this compound(52287-51-1)Recommanded Product: 52287-51-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 814-94-8, is researched, SMILESS is O=C([O-])C([O-])=O.[Sn+2], Molecular C2O4SnJournal, Article, ChemSusChem called A Bronsted Acidic Ionic Liquid as an Efficient and Selective Catalyst System for Bioderived High Molecular Weight Poly(ethylene 2,5-furandicarboxylate), Author is Qu, Xiao-ling; Jiang, Min; Wang, Bing; Deng, Jin; Wang, Rui; Zhang, Qiang; Zhou, Guang-yuan; Tang, Jun, the main research direction is bronsted acidic ionic liquid catalyst bioderived polyethylene furandicarboxylate; ecofriendly bioderived polyester polyfuran ionic liquid catalyst green chem; Brønsted acids; biomass valorization; hydrogen bonding; ionic liquids; polymers.Product Details of 814-94-8.

Green synthesis of bioderived high-mol.-weight poly(ethylene 2,5-furandicarboxylate) (PEF) over metal-free catalysts is a significant challenge. This study focuses on PEF prepared from ethylene glycol and 2,5-furandicarboxylic acid (FDCA) through a direct esterification method with ecofriendly metal-free ionic liquids (ILs) as catalysts. The catalytic activities of a series of imidazolium cations in the presence of various anions are systematically investigated and found to be mainly governed by the anions. Among the ILs studied, 1-ethyl-3-methylimidazolium tetrafluoroborate ([C2MIM]BF4) is identified as the best catalyst, showing excellent catalytic activity, selectivity, and stability, even at low catalyst loadings (0.1 mol % w.r.t. FDCA). Optimization of the polymerization parameters enables [C2MIM]BF4-catalyzed production of PEF with a high number-average mol. weight (Mn=5.25×104 g mol-1). The relationship between Bronsted acidity and catalytic activity is also investigated and the results show that the trend in catalytic activity is in good agreement with that in Bronsted acidity, as determined by the Hammett method. Addnl., on the basis of exptl. results and d. functional theory calculations, an electrophilic activation mechanism induced by hydrogen bonds is proposed. This strategy of adjustable acidity and anion structure in ILs provides an opportunity to develop other ILs for bio-based polyesters through green synthesis pathways.

After consulting a lot of data, we found that this compound(814-94-8)Product Details of 814-94-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Name: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Microfluidic-enabled versatile hyphenation of electromembrane extraction and thin film solid phase microextraction. Author is Alidoust, Mina; Yamini, Yadollah; Baharfar, Mahroo; Seidi, Shahram; Rasouli, Fatemeh.

In the present study, a versatile combination of electromembrane extraction (EME) with thin film solid phase microextraction (TF-SPME) was introduced using a microfluidic chip device. The device consisted of two single channels on two sep. layers. The upper channel was dedicated to donor phase flow pass, while the beneath channel was used as a reservoir for stagnant acceptor solution A slide of fluorine doped tin oxide (FTO) was accommodated in the bottom of the acceptor phase channel. A thin layer of polyaniline was electrodeposited on the FTO surface to achieve the required thin film for TF-SPME. A stainless-steel wire was embedded in the donor phase channel and another wire was also attached to the FTO surface. The channels were separated by a piece of polypropylene membrane impregnated with 1-octanol and the whole chip was fixed with bolts and nuts. The driving force for the extraction was an 8 V d.c. (DC) voltage applied across the supported liquid membrane (SLM). Under the influence of the elec. field, analytes immigrated from sample towards the acceptor phase and then adsorbed on the thin film of the solid phase. Finally, the analytes were desorbed by successive movement of a desorption solvent in the acceptor phase channel followed by injection of the desorption solution to HPLC-UV. The applicability of the proposed device was demonstrated by the determination of four synthetic food dyes: Amaranth, Ponceau 4R, Allura Red, and Carmoisine, as the model analytes. The effective parameters on the efficiency of the both EME and TF-SPME were investigated. Under the optimized conditions, the microchip provided low LODs (1-10μg L-1), and a wide linear dynamic range of 10-1000μg L-1 for all analytes. The system also offered RSD values lower than 5.5% and acceptable reusability of the thin film for multiple extractions

After consulting a lot of data, we found that this compound(25956-17-6)Name: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Applied Microbiology and Biotechnology called Characterisation of nitrilase and nitrile hydratase biocatalytic systems, Author is Brady, D.; Beeton, A.; Zeevaart, J.; Kgaje, C.; van Rantwijk, F.; Sheldon, R. A., which mentions a compound: 17190-29-3, SMILESS is N#CCC(O)C1=CC=CC=C1, Molecular C9H9NO, Name: 3-Hydroxy-3-phenylpropanenitrile.

Biocatalytic transformations converting aromatic and arylaliph. nitriles into the analogous related amide or acid were investigated. These studies included synthesis of the β-substituted nitrile 3-hydroxy-3-phenylpropionitrile, subsequent enrichment and isolation on this substrate of nitrile-degrading microorganisms from the environment, and a comparative study of enzymic reactions of nitriles by resting cell cultures and enzymes. Each biocatalyst exhibited a distinctive substrate selectivity profile, generally related to the length of the aliphatic chain of the arylaliph. nitrile and the position of substituents on the aromatic ring or aliphatic chain. Cell-free nitrilases generally exhibited a narrower substrate range than resting whole cells of Rhodococcus strains. The Rhodococcus strains all exhibited nitrile hydratase activity and converted β-hydroxy nitriles (but did not demonstrate enantioselectivity on this substrate). The biocatalysts also mediated the synthesis of a range of α-hydroxy carboxylic acids or amides from aldehydes in the presence of cyanide. The use of an amidase inhibitor permits halting the nitrile hydratase/amidase reaction at the amide intermediate.

After consulting a lot of data, we found that this compound(17190-29-3)Name: 3-Hydroxy-3-phenylpropanenitrile can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics