Day: April 12, 2022

Electric Literature of C9H9NO. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Reductive and oxidative cleavage of 5-phenyl-2-isoxazoline-3-carboxylic acid. Author is King, G. S.; Magnus, P. D.; Rzepa, H. S..

Reductive cleavage of 5-phenyl-2-isoxazoline-3-carboxylic acid (I) with Zn-AcOH gave 4-phenyl-2-acetamido-γ-butyrolacetone; oxidative fragmentation of tert-Bu 5-phenyl-2-isoxazoline-3-peroxycarboxylate (II) and tert-Bu 5-phenylisoxazole-3-peroxycarboxylate (III) paralleled the mass spectral fragmentation giving BzH and PhCH(OH)CH2CN, and 5-phenylisoxazole-3-carboxylic acid (IV), resp.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about One-Pot Nitrile Aldolization/Hydration Operation Giving β-Hydroxy Carboxamides.Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile.

A straightforward method to provide 3-hydroxy carboxamides from aldehydes, nitriles, and water is reported. The method is atom-economical and redox neutral. The present reaction is essentially the first example of the catalytic aldol reaction of “”unactivated”” carboxamides (CONH2). No protection/activation/deprotection sequence is needed and thus the formation of a stoichiometric amount of salt waste is obviated.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product Details of 814-94-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Tin(II) oxalate, is researched, Molecular C2O4Sn, CAS is 814-94-8, about Template-assisted synthesis and electrochemical properties of SnO2 as a cathode catalyst support for PEMFC. Author is Chikunova, Iuliia O.; Semeykina, Victoriya S.; Kuznetsov, Aleksey N.; Kalinkin, Peter N.; Gribov, Evgueny N.; Parkhomchuk, Ekaterina V..

SnO2 is a promising material for electro- and photocatalysis sensors. In the electrocatalysis field, SnO2 is able to serve as a stable catalyst support for PEMFC cathodes. In this work, SnO2 were synthesized using SnCl4 or SnC2O4 and polystyrene microspheres as a template. The materials were characterized by XRD spectroscopy, CHNS anal., low temperature (77 K) N2 adsorption, mercury intrusion porosimetry (MIP) and SEM. The SnC2O4 decomposition resulted in obtaining SnO2 with high conductivity up to 0.275 S/cm according to impedance spectroscopy. The increase in aging time and PS loading improves SnO2 conductivity and stability. The potential cycling test in 1.0-1.5 V RHE range revealed that stability of the most stable SnO2 is higher than that of CB Ketjen Black EC-300J and comparable with that of Vulcan XC-72R. The ORR activities of Pt catalyst based on macroporous SnO2 showed values similar to those of Pt/SnO2 found in literature.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine(SMILESS: BrC1=CC=C2OCCOC2=C1,cas:52287-51-1) is researched.Formula: C8H7BrO2. The article 《Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists》 in relation to this compound, is published in Scientific Reports. Let’s take a look at the latest research on this compound (cas:52287-51-1).

Although several potent bile acid Farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5 (TGR5, GPBAR1) dual agonists such as INT-767 have been reported, no non-bile acid FXR/TGR5 dual agonist has been investigated to date. Therefore, we attempted to discover potent non-bile acid FXR/TGR5 dual agonists and identified some non-bile acid FXR/TGR5 dual agonists, such as isonicotinamide derivatives in vitro assay. Compound 20p was evaluated in C57BL/6J mice, that were administered a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) consisting of 60 kcal% fat and 0.1% methionine by weight for one week. Compound 20p dose-dependently induced small heterodimer partner (SHP) mRNA and decreased cytochrome P 450 7A1 (CYP7A1) in the liver at 10 and 30 mg/kg, resp., which were used as FXR agonist markers. Compound 20p significantly increased the plasma levels of GLP-1 as a TGR5 agonist, and a high concentration of GLP-1 lowered blood glucose levels. We confirmed that compound 20p was a non-bile acid FXR/TGR5 dual agonist.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C8H7BrO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about Palladium-catalyzed benzylic C(sp3)-H carbonylative arylation of azaarylmethyl amines with aryl bromides. Author is Zhao, Haoqiang; Hu, Bowen; Xu, Lijin; Walsh, Patrick J..

A highly selective palladium-catalyzed carbonylative arylation of weakly acidic benzylic C(sp3)-H bonds of azaarylmethylamines with aryl bromides under 1 atm of CO gas has been achieved. This work represents the first examples of use of such weakly acidic pronucleophiles in this class of transformations. In the presence of a NIXANTPHOS-based palladium catalyst, this one-pot cascade process allows a range of azaarylmethylamines containing pyridyl, quinolinyl and pyrimidyl moieties and acyclic and cyclic amines to undergo efficient reactions with aryl bromides and CO to provide α-amino aryl-azaarylmethyl ketones in moderate to high yields with a broad substrate scope and good tolerance of functional groups. This reaction proceeds via in situ reversible deprotonation of the benzylic C-H bonds to give the active carbanions, thereby avoiding prefunctionalized organometallic reagents and generation of addnl. waste. Importantly, the operational simplicity, scalability and diversity of the products highlight the potential applicability of this protocol.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 17190-29-3, is researched, Molecular C9H9NO, about Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles, the main research direction is bromoisoxazoline ring opening; ring opening reaction mechanism; hydroxy nitrile preparation.Safety of 3-Hydroxy-3-phenylpropanenitrile.

3-Bromo-2-isoxazolines were converted to the corresponding β-hydroxy nitriles by treatment with sodium iodide in the presence of either chlorotrimethylsilane or p-toluenesulfonic acid. Both methods gave β-hydroxy nitriles under relatively mild conditions in good to moderate yields for a variety of substituted 3-bromo-2-isoxazolines.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 25956-17-6, is researched, Molecular C18H14N2Na2O8S2, about Development and Optimization of Asenapine Sublingual Film Using QbD Approach, the main research direction is asenapine sublingual film QbD approach; In vivo absorption; asenapine; critical quality attributes; quality by design; quality target product profile; sublingual film.Product Details of 25956-17-6.

Asenapine, an atypical antipsychotic agent, has been approved for the acute and maintenance treatment of schizophrenia and manic episodes of bipolar disorder. However, the extensive hepatic metabolism limits its oral bioavailability. Therefore, the objective of the current investigation was to develop sublingual film containing asenapine to enhance the therapeutic efficacy. Sublingual films containing asenapine were fabricated using polyethylene oxide and hydroxypropyl methylcellulose by solvent casting method. Design of experiment was used as a statistical tool to optimize the proportion of the film-forming polymers in order to establish the critical quality attributes of the drug formulation. The process was studied in detail by assessing risk of each step as well as parameters and material attributes to reduce the risk to a min. A control strategy was defined to ensure manufacture of films according to the target product profile by evaluation of intermediate quality attributes at the end of each process step. Results of optimized formulations showed rapid disintegration, adequate folding endurance, good percentage elongation, tensile strength, and viscosity. Besides, the results from the in vitro dissolution/ex vivo permeation studies showed rapid dissolution (100% in 6 min) and higher asenapine permeation (∼ 80% in 90 min) through the sublingual epithelium. In vivo study indicates greater asenapine absorption (31.18 ± 5.01% of administered dose) within 5 min and was comparable with marketed formulation. In summary, the designing plan to develop asenapine formulation was successfully achieved with desired characteristics of the delivery tool for sublingual administration.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Electrochemical sensor based on ionic liquid and carbon black for voltammetric determination of Allura red colorant at nanomolar levels in soft drink powders.Recommanded Product: 25956-17-6.

The ionic liquid (IL) 1-butyl-3-methylimidazolium tetrafluoroborate and carbon black (CB) nanoparticles were incorporated within a crosslinked chitosan film over the surface of a glassy carbon electrode, and the obtained architecture explored to the sensitive voltammetric sensing of Allura red colorant in soft drinking powders. The different electrodic surfaces were morphol. and electrochem. characterized. From the modification of glassy carbon electrode with IL and CB, a significantly enhanced voltammetric response was achieved toward the Allura red irreversible oxidation reaction. The type and amount of IL employed in the electrode modification step as well as all the others exptl. parameters affecting the sensor response by square-wave adsorptive anodic stripping voltammetry (SWAdASV) were systematically optimized. Under the optimum exptl. conditions, the proposed SWAdASV procedure provided a linear anal. curve in the concentration range of 3.98 × 10-8 to 9.09 × 10-7 mol L-1 and a low limit of detection of 9.1 × 10-10 mol L-1 (0.91 nmol L-1). The proposed sensor presented good precision and no matrice effects as shown from repeatability tests, concomitant studies and addition/recovery assays. The developed SWAdASV procedure was applied successfully in the determination of Allura red content in com. soft drink powder samples, and the results were in close agreement with those obtained using a comparative spectrophotometric method at a confidence level of 95%.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 25956-17-6, is researched, SMILESS is O=S(C1=CC=C2C(/N=N/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+], Molecular C18H14N2Na2O8S2Journal, Chemical Data Collections called Development of electrochemical sensor for adrenaline at poly (allura red) modified carbon paste electrode: A voltammetric study, Author is chandra H D, Madhu; Kumara Swamy, B. E., the main research direction is adrenaline allura red voltammetry carbon paste electrode electrochem sensor.Computed Properties of C18H14N2Na2O8S2.

Poly (allura red) modified carbon paste electrode (MCPE) sensor is developed for the electrochem. determination of Adrenaline (AD) in the presence of Uric acid (UA), by cyclic voltammetric and differential pulse voltammetric techniques. Developed Poly (allura red) MCPE is more sensitive and selective. The effect of pH, scan rate and concentration on the oxidation of adrenaline were studied, LOD 6.8μM, LOQ 22μM for AD and LOD 17μM, LOQ 54μM for UA resp. and the poly (allura red) modified carbon paste electrode is applied for the simultaneous determination of adrenaline and Uric acid, the Poly (allura red) MCPE has capable of determining both AD and UA individually with two identical different oxidation peaks for AD and UA. This method can be used for some other bioactive mols.

Compounds in my other articles are similar to this one(Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate)Computed Properties of C18H14N2Na2O8S2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Terminal Trifluoromethylation of Ketones via Selective C-C Cleavage of Cycloalkanols Enabled by Hypervalent Iodine Reagents, published in 2021-12-03, which mentions a compound: 52287-51-1, mainly applied to trifluoromethyl ketone preparation; cycloalkanol Togni reagent trifluoromethylation photoredox copper catalyst, Application of 52287-51-1.

The first terminal trifluoromethylation at aryl and alkyl ketone’s γ, δ, ε, or more remote sites via selective C-C bond cleavage of cycloalkanols was reported. The noncovalent interactions between alcs. and hypervalent iodines(III) reagents were disclosed to activate both alcs. and the Togni I reagent in the dual photoredox/copper catalysis for the transformation. This reaction was scalable to the gram-scale synthesis, applicable to the structurally complex steroid trifluoromethylation, and extendable to the pentafluoroethylation.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics