Day: April 7, 2022

Wang, Yuzhuo; Wang, Lei; Chen, Mingjie; Tu, Youshao; Liu, Yu; Zhang, Junliang published an article about the compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine( cas:52287-51-1,SMILESS:BrC1=CC=C2OCCOC2=C1 ).Application of 52287-51-1. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:52287-51-1) through the article.

An efficient palladium-catalyzed enantioselective carboamination reaction of N-Boc-O-homoallyl-hydroxylamines and N-Boc-pent-4-enylamines with aryl or alkenyl bromides was developed, delivering various substituted isoxazolidines I [R = H, Me; R1 = Ph, 3-thienyl, 2-naphthyl, etc.] and pyrrolidines II [R1 = 4-PhC6H4, 3,4-MeO2C6H3, 1-naphthyl, etc.; R2 = H, Me; R3 = Boc, Cbz] in good yields with up to 97% ee. The reaction featured mild conditions, general substrate scope and scalability. The obtained products could be transformed into chiral 1,3-aminoalc. derivatives without erosion of chirality. The newly identified Xu-Phos ligand bearing an ortho-OiPr group was responsible for the good yield and high enantioselectivity.

Compound(52287-51-1)Application of 52287-51-1 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine), if you are interested, you can check out my other related articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Saito, Yutaro; Segawa, Yasutomo; Itami, Kenichiro published the article 《para-C-H Borylation of benzene derivatives by a bulky iridium catalyst》. Keywords: boration monosubstituted benzene para selective iridium BIPHEP catalyst; arylboronic ester preparation para selective boration aromatic substitution.They researched the compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I)( cas:1300746-79-5 ).Application of 1300746-79-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1300746-79-5) here.

A highly para-selective aromatic C-H borylation has been accomplished. By a new iridium catalyst bearing a bulky diphosphine ligand, Xyl-MeO-BIPHEP, the C-H borylation of monosubstituted benzenes can be affected with para-selectivity up to 91%. This catalytic system is quite different from the usual iridium catalysts that cannot distinguish meta- and para-C-H bonds of monosubstituted benzene derivatives, resulting in the preferred formation of meta-products. The para-selectivity increases with increasing bulkiness of the substituent on the arene, indicating that the regioselectivity of the present reaction is primarily controlled by steric repulsion between substrate and catalyst. Caramiphen, an anticholinergic drug used in the treatment of Parkinson’s disease, was converted into five derivatives via our para-selective borylation. The present [Ir(cod)OH]2/Xyl-MeO-BIPHEP catalyst represents a unique, sterically controlled, para-selective, aromatic C-H borylation system that should find use in streamlined, predictable chem. synthesis and in the rapid discovery and optimization of pharmaceuticals and materials.

Compound(1300746-79-5)Application of 1300746-79-5 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((1,10-Phenanthroline)(trifluoromethyl)copper(I)), if you are interested, you can check out my other related articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Computed Properties of C13H8CuF3N2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Tetralithiated Tetraazaperopyrene as a Key Intermediate for the Synthesis of Functionalized Derivatives. Author is Hahn, Lena; Wadepohl, Hubert; Gade, Lutz H..

A new synthetic approach to core-functionalized tetraazaperopyrenes (TAPP) is reported. In-situ reaction of 4-fold lithiated TAPP with electrophiles results in the formation of various unprecedented TAPP derivatives, which are highly emissive fluorophores, show promising photophys. and electrochem. properties and act as valuable starting materials [e.g., I (formed in situ from tetrabromo precursor) + ClPPh2 → II (46%)]. Thus, lithiation of the TAPP core opens up a facile way for developing new organic materials.

Compound(1300746-79-5)Computed Properties of C13H8CuF3N2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((1,10-Phenanthroline)(trifluoromethyl)copper(I)), if you are interested, you can check out my other related articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C9H9NO. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Reactions of pentafluorophenyltrimethylsilane and cyanomethyltrimethylsilane with carbonyl compounds catalyzed by cyanide anions. Author is Gostevskii, B. A.; Kruglaya, O. A.; Albanov, A. I.; Vyazankin, N. S..

Treatment of pentafluorophenyltrimethylsilane (I) and cyanomethyltrimethylsilane (II) with enolizable ketones in the presence of a catalytic amount of potassium cyanide-18-crown-6 complex gave the corresponding trimethylsilyl enol ethers. The same dehydrogenative silylation of acetylacetone and benzoylacetone with silane I was extended to the preparation of 2,4-bis(trimethylsiloxy)-1,3-pentadiene and 1-phenyl-1,3-bis(trimethylsiloxy)-1,3-butadiene, resp. The dehydrogenative silylation of acetylacetone and benzoylacetone with dimethylbis(pentafluorophenyl)silane under the same conditions affords novel heterocycles 5-methylene-2,6-dioxa-1-silacyclohex-3-enes. In the reaction studied the silylating ability of the silanes increases in the order Me3SiCN ≃ Me2Si(CN)2 < Me3SiCH2CN < Me3SiC6F5 ≃ Me2Si(C6F5)2. Potassium cyanide-18-crown complex catalyzed the addition of silane I or II to a carbonyl group of non-enolizable compounds such as benzaldehyde, crotonaldehyde, and methyl(triethylgermyl)ketene. Compound(17190-29-3)Formula: C9H9NO received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(3-Hydroxy-3-phenylpropanenitrile), if you are interested, you can check out my other related articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pliuta, Konstantin; Chebotarev, Alexander; Pliuta, Anastasia; Snigur, Denys published an article about the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6,SMILESS:O=S(C1=CC=C2C(/N=N/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+] ).Recommanded Product: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:25956-17-6) through the article.

In current study the carbon-paste electrode modified by silica with embedded cetylpyridinium chloride for determination of Allura Red AC have been developed. The optimal conditions were determined to be for the square-wave voltammetric quantification: pH=2, Eads=300 mV, tads=300 s, amplitude – 40 mV, frequency – 25 Hz and potential scan rate is 250 mV sec-1. The calibration plot has linearity in the concentration ranges 0.04-0.2μM and 0.2-1.00μM. The LOD and LOQ are equal to 0.005μM and 0.015μM resp. The crafted sensor has been applied successfully to model solutions and in jelly candies anal. with RSD no more than 10%.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Derivatives of 1,4-benzodioxan. I. Some halogenated 1,4-benzodioxans and amino and nitro derivatives thereof》. Authors are Heertjes, P. M.; Knape, A. A.; Talsma, H.; Andriesse, P..The article about the compound:6-Bromo-2,3-dihydrobenzo[b][1,4]dioxinecas:52287-51-1,SMILESS:BrC1=CC=C2OCCOC2=C1).Reference of 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine. Through the article, more information about this compound (cas:52287-51-1) is conveyed.

6-Bromo-1,4-benzodioxan (I), b23 153-4°, was obtained in 60% yield by the method of Ghosh (C.A. 10, 455). I (18.35 g.) in 25 ml. H2O treated dropwise at 60° with 5.5 ml. HNO3 (d. 1.52) gave 60% 6-bromo-7-nitro-1,4-benzodioxan (II), m. 171.9-2.1°. 6-Amino-7-nitro-1,4-benzodioxan (III) (5 g.) in 10 ml. concentrated H2SO4 and 25 ml. H2O diazotized at 20° with 1.75 g. NaNO2 in 3 ml. H2O, then refluxed 3 hrs. with 1.6 g. CuSO4, 0.5 g. Cu turnings, 4 g. NaBr.2H2O, 2 ml. concentrated H2SO4, and 25 ml. H2O gave 60% II. II (2.85 g.) treated at 0° with 12 ml. HNO3 and left 2 hrs. at room temperature yielded 3 g. (80%) crude 6-bromo-5(?),7,8(?)-trinitro-1,4-benzodioxan (IV), m. 248.2-8.6° after crystallization from EtOH-HOAc (1:1) and iso-BuOH. II (5 g.) subjected to cathodic reduction yielded 24% 6-amino-7-bromo-1,4-benzodioxan (V) as the HCl salt (1.25 g.). 6-Acetamido-7-bromo-1,4-benzodioxan (VI) (1.02 g., 80%), m. 179.1-9.4°, was prepared from V.HCl by acetylation for 15 min. with NaOAc and Ac2O in a small amount of H2O. 6-Acetamido-1,4-benzodioxan (VIA) (11.2 g.) was brominated to 14 g. (89%) VI. II (10 g.) reduced, extracted, refluxed 15 min. with concentrated HCl and EtOH, diluted, made alk. with NaOH, extracted with C6H6, and HCl, gas passed into the extract precipitated 6.4 g. (70%) V.HCl. 1,4-Benzodioxan (VII) (300 g.) brominated overnight with Br in HOAc yielded 518 g. (80%) 6,7-dibromo-1,4-benzodioxan (VIII), m. 139.6-40.0°. V.HCl (5 g.) diazotized and treated with refluxing Cu2Br2 gave 3.5 g. (63%) crude VIII. The mother liquor after separation of VIII from VII gave 5(?),6,7,8(?)tetrabromo-1,4-benzodioxan (IX), m. 212.8-13.4°. VIII (297 g.) on nitration gave 361 g. (93%) crude 6,7-dibromo-5,8-dinitro-1,4-benzodioxan (X); recrystallized, it m. 318-19°. When 80 g. X was heated with 600 g. SnCl2.2H2O in 600 ml. concentrated HCl and 600 ml. EtOH, a rapid endothermic reaction occurred at 60°, and when the temperature was kept at 60-70° the reaction was complete in 30 min.; working up gave 41.5 g. (84%) 5,8-diamino-1,4-benzodioxan (XI) as the HCl salt; alternatively, the free XI m. 99.1-9.7° was isolated, XI with excess Ac2O gave 64% di-Ac derivative (XII), m. 287-9°; 1 mole Ac2O gave the mono-Ac derivative (XIII), m. 141.2-1.9°. XIII yields azo dyes. VII (76 g.) in 200 ml. HOAc treated with Cl at 10-20° yielded 80.7 g. (71%) 6,7-dichloro-1,4-benzodioxan (XIV), m. 150.6-1.1°. 4,5-Dichloropyrocatechol (7.5 g.) and 75 g. (CH2Br)2 in 50 ml. (CH2OH)2, heated at 140° and treated with anhydrous K2CO3 until the mixture no longer gave a blue color with FeCl3 (3-4 hrs.), afforded 6.8 g. (70%) XIV. Nitration of XIV gave 84% 6,7-dichloro-5,8-dinitro-1,4-benzodioxan (XV), m. 287.78.6°, which, reduced with SnCl2 and HCl in EtOH and acetylated in C6H6 at 50°, gave 5,8-diacetamido-6,7-dichloro-1,4-benzodioxan (XVI), m. 299.0-300.3° (decomposition). Alternatively, HCl was passed into a mixture of 50 g. SnCl2.2H2O in 100 ml. HOAc and heated with 5 g. XV; at 60° reaction set in with a rise in temperature to 90°, and was complete in 1 hr., yielding 5,8-diamino-6,7-dichloro-1,4-benzodioxan (XVII), decompose 137-40°, slowly oxidizes in air. The HCl salt of 6-amino-1,4-benzodioxan (XVIII) (39 g.) in 65 ml. H2O and 65 ml. concentrated HCl diazotized at 0° with 18 g. NaNO2 in 40 ml. H2O and the solution added to 30 g. Cu2Cl2 in 100 ml. concentrated HCl and heated at 70°, gave 26 g. (76%) 6-chloro-1,4-benzodioxan (XIX), b3 98-100°. XIX (5 g.) nitrated with HNO3-H2SO4 at 15° and the product crystallized from Me2CO-HOAc (1:1) gave 4.5 g. (73%) 6-chloro-7-nitro-1,4-benzodioxan (XX), m. 161.7-2.1°, also prepared by diazotization of III and then treatment with Cu2Cl2. VIA (20.4 g.) in 100 ml. HOAc, treated with 1.9 g. Cl in 50 ml. HOAc, the solution added to H2O and the product crystallized from 50% aqueous Me2CO gave 6-acetamido-7-chloro-1,4-benzodioxan (XXI), m. 171.7-2.4°. Hydrogenation of 4 g. XX in EtOH in the presence of Raney Ni at room temperature, filtration, and acidification with HCl gave 4 g. (97%) of the HCl salt of 6-amino-7-chloro-1,4-benzodioxan (XXII); acetylation gave a crude yield of 86% crude XXI, converted into the HCl salt of XXII.HCl by refluxing with 1:1 EtOH-concentrated HCl.

Compound(52287-51-1)Reference of 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine), if you are interested, you can check out my other related articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Name: 3-Hydroxy-3-phenylpropanenitrile. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about PbCl2/Ga bimetal redox system-mediated carbon-carbon bond formation reactions between carbonyl compounds and ethyl trichloroacetate and iodoacetonitrile. Author is Zhang, Xiao-Lin; Han, Ying; Tao, Wen-Tian; Huang, Yao-Zeng.

In the presence of lead dichloride and a metallic gallium bimetal redox system, carbonyl compounds reacted with Et trichloroacetate and iodoacetonitrile to afford Et β-substituted α,α-dichloropropionates and β-hydroxy nitriles, resp., in moderate to excellent yields.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: 52287-51-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about Elucidating the Structure-Property Relationships of Donor-π-Acceptor Dyes for Dye-Sensitized Solar Cells (DSSCs) through Rapid Library Synthesis by a One-Pot Procedure. Author is Fuse, Shinichiro; Sugiyama, Sakae; Maitani, Masato M.; Wada, Yuji; Ogomi, Yuhei; Hayase, Shuzi; Katoh, Ryuzi; Kaiho, Tatsuo; Takahashi, Takashi.

The preparation of organic dyes with excellent high power conversion efficiency is important for the further improvement of dye-sensitized solar cells. We describe the rapid synthesis of a 112-membered donor-π-acceptor dye library by a one-pot procedure, evaluation of power conversion efficiencies, and elucidation of structure-property relationships. No obvious correlations between molar absorption coefficient and the η were observed, whereas the HOMO and LUMO levels of the dyes were critical for η. The dyes with a more pos. EHOMO, and with an ELUMO < -0.80 V, exerted higher power conversion efficiencies. The proper driving forces were crucial for a high short-circuit c.d., and it was the most important parameter for a high η. The above criteria of EHOMO and ELUMO should be useful for creating high power conversion efficiency dyes; nevertheless, that was not sufficient for identifying the best combination of donor, π, and acceptor blocks. Combinatorial synthesis and evaluation was important for identifying the best dye. Compound(52287-51-1)HPLC of Formula: 52287-51-1 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine), if you are interested, you can check out my other related articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

SDS of cas: 1300746-79-5. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core.

Integrins αvβ5 and αvβ3 are closely related, proangiogenic members of the wider RGD-binding integrin family. Due to their high sequence homol., the development of αvβ5-selective compounds has remained elusive to synthetic and medicinal chemists. Herein, we describe a survey of SAR around a series of amide-containing 3-aryl-succinamic acid-based RGD mimetics. This resulted in the discovery of α,α,α-trifluorotolyl I which exhibits 800 x selectivity for αvβ5vs. αvβ3 with a pyrrolidine amide linker that confers selectivity for αvβ5 by positioning a key aryl ring in the SDL of αvβ5 with good complementarity; binding in this mode is disfavored in αvβ3 due to clashes with key residues in the β3-subunit. Compound I exhibits selective inhibition by a cell adhesion assay, high passive permeability and solubility which enables potential use of this inhibitor as an αvβ5-selective in vitro tool compound

Compound(1300746-79-5)SDS of cas: 1300746-79-5 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((1,10-Phenanthroline)(trifluoromethyl)copper(I)), if you are interested, you can check out my other related articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: 814-94-8. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Tin(II) oxalate, is researched, Molecular C2O4Sn, CAS is 814-94-8, about Cerium-doped SnO2 nanomaterials with enhanced gas-sensitive properties for adsorption semiconductor sensors intended to detect low H2 concentrations. Author is Fedorenko, George; Oleksenko, Ludmila; Maksymovych, Nelly; Vasylenko, Inna.

Abstract: Highly sensitive to H2 sensors were created on the base of material obtained through tin (II) oxalate oxidation by hydrogen peroxide water solution It has been established that the addition of 0.1 wt% Ce to the sensor materials significantly increases response values of the sensors to hydrogen micro-concentrations in air (44 ppm H2). Nanoscale nature of the obtained sensor materials was confirmed by transmission electron microscopy and X-ray diffraction anal. The average particle size of the obtained 0.1 wt% Ce/SnO2 sensor materials was found to be 10.6 nm. The sensors doped with 0.1 wt% Ce exhibit enhanced gas sensing properties: a wide concentration range of H2 detection in air, relatively high selectivity to hydrogen and good repeatability of the response to H2 during long-term sensor operation (2 mo). Anal. of the previously reported data has revealed a promising combination of high sensitivity to hydrogen and fast response time with low Ce loading for sensors based on Ce/SnO2 material obtained in this work.

Compound(814-94-8)HPLC of Formula: 814-94-8 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Tin(II) oxalate), if you are interested, you can check out my other related articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics