Month: April 2022

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mejia-Otalvaro, Felipe; Merino-Restrepo, Andres; Hormaza-Anaguano, Angelina researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).Related Products of 25956-17-6.They published the article 《Evaluation of a Trametes pubescens laccase concentrated extract on allura red AC decolorization without the addition of synthetic mediators》 about this compound( cas:25956-17-6 ) in Journal of Environmental Management. Keywords: Trametes laccase allura red AC decolorization wastewater treatment; Bioremediation; Dye decolorization; Immobilization; Ligninolytic enzymes; White-rot fungi. We’ll tell you more about this compound (cas:25956-17-6).

Synthetic dye bioremediation is a topic of great importance since these pollutants possess toxic effects, and huge quantities of them are being discharged into water bodies. Ligninolytic enzyme treatment stands out for being a cost-effective methodol., capable of obtaining high decolorization levels. In this work, a laccase enzyme treatment was evaluated to effectively perform a cycle of dye bioremediation. Furthermore, a dye decolorization improvement was also assessed through laccase immobilization. Particularly, a Trametes pubescens enzyme extract was concentrated, immobilized onto calcium alginate beads, and characterized to assess its dye decolorization potential. Ammonium sulfate precipitation and vacuum evaporation were evaluated to concentrate the crude extract and to decolorize allura red AC. Both treatments reached a high enzyme yield recovery (>90%), but only the vacuum-evaporated extract achieved a high allura red AC decolorization level after 16 h of contact time. This suggested that essential compounds for allura red AC decolorization were present in the crude extract, implying that neither a complete laccase purification process nor an addition of synthetic mediators are necessary. Under optimized immobilization conditions, 94.6% immobilization efficiency and 49.8% activity recovery were obtained with 0:1 alginate:enzyme (volume/volume), 100 mM CaCl2, and 5.0% w/v sodium alginate. Furthermore, by immobilizing the laccase concentrated extract, both the pH and temperature stabilities were improved. The decolorization of allura red AC by free and immobilized laccase was 68.4% and 4.6%, resp., showing that although the enzyme stability was improved, dye decolorization was neg. affected. Thus, an efficient allura red AC decolorization was obtained with concentrated-free laccase by a feasible and low-cost methodol.

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Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Computed Properties of C8H7BrO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about Rhodium-Catalyzed Direct Arylation of Furopyridine: Synthesis and the Cardiac Effects of Dictamnine Derivatives. Author is Du, Yufeng; Huang, Linyu; Wang, Neng; Li, Xiaohuan; Zhou, Xian-Li; Zhang, Lan; Huang, Shuai; Walsh, Patrick J.; Gao, Feng.

Synthesis of Rh2(OAc)4/IMes·HCl system promotes the chemoselective installation of aryl groups at the 2-position of furo[2,3-b]pyridines I (R = Ph, naphthalen-1-yl, 2,3-dihydro-1,4-benzodioxin-6-yl, etc.) (53-94% yields). The method is applicable to the direct modification of the natural furoquinoline alkaloid dictamnine. The cardiac effects of the fluorinated analogs II were improved, and compared to dictamnine at 160 μg/mL. Preliminary mechanism of action studies indicate that the effects might be related to epinephrine αreceptors, M-receptor and calcium channel receptor.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zorina, L. N.; Safiev, O. G.; Chanyshev, R. R.; Zorin, V. V.; Rakhmankulov, D. L. published the article 《Preparation of halogenated benzodioxacycloalkanes》. Keywords: benzodioxole sodium hypochlorite halogenation; benzodioxan sodium hypobromite halogenation; halobenzodioxole preparation; halobenzodioxan preparation.They researched the compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine( cas:52287-51-1 ).Recommanded Product: 52287-51-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:52287-51-1) here.

Reaction of 1,3-benzodioxole (I) and 1,4-benzodioxan (II) with NaOCl and NaOBr in presence of sulfuric acid resulted in mono- and dihalogenated derivatives of I and II. Regioselectivity of this reaction depended on the reagents ratio.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 814-94-8, is researched, SMILESS is O=C([O-])C([O-])=O.[Sn+2], Molecular C2O4SnJournal, Article, ChemSusChem called A Bronsted Acidic Ionic Liquid as an Efficient and Selective Catalyst System for Bioderived High Molecular Weight Poly(ethylene 2,5-furandicarboxylate), Author is Qu, Xiao-ling; Jiang, Min; Wang, Bing; Deng, Jin; Wang, Rui; Zhang, Qiang; Zhou, Guang-yuan; Tang, Jun, the main research direction is bronsted acidic ionic liquid catalyst bioderived polyethylene furandicarboxylate; ecofriendly bioderived polyester polyfuran ionic liquid catalyst green chem; Brønsted acids; biomass valorization; hydrogen bonding; ionic liquids; polymers.Product Details of 814-94-8.

Green synthesis of bioderived high-mol.-weight poly(ethylene 2,5-furandicarboxylate) (PEF) over metal-free catalysts is a significant challenge. This study focuses on PEF prepared from ethylene glycol and 2,5-furandicarboxylic acid (FDCA) through a direct esterification method with ecofriendly metal-free ionic liquids (ILs) as catalysts. The catalytic activities of a series of imidazolium cations in the presence of various anions are systematically investigated and found to be mainly governed by the anions. Among the ILs studied, 1-ethyl-3-methylimidazolium tetrafluoroborate ([C2MIM]BF4) is identified as the best catalyst, showing excellent catalytic activity, selectivity, and stability, even at low catalyst loadings (0.1 mol % w.r.t. FDCA). Optimization of the polymerization parameters enables [C2MIM]BF4-catalyzed production of PEF with a high number-average mol. weight (Mn=5.25×104 g mol-1). The relationship between Bronsted acidity and catalytic activity is also investigated and the results show that the trend in catalytic activity is in good agreement with that in Bronsted acidity, as determined by the Hammett method. Addnl., on the basis of exptl. results and d. functional theory calculations, an electrophilic activation mechanism induced by hydrogen bonds is proposed. This strategy of adjustable acidity and anion structure in ILs provides an opportunity to develop other ILs for bio-based polyesters through green synthesis pathways.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Name: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Microfluidic-enabled versatile hyphenation of electromembrane extraction and thin film solid phase microextraction. Author is Alidoust, Mina; Yamini, Yadollah; Baharfar, Mahroo; Seidi, Shahram; Rasouli, Fatemeh.

In the present study, a versatile combination of electromembrane extraction (EME) with thin film solid phase microextraction (TF-SPME) was introduced using a microfluidic chip device. The device consisted of two single channels on two sep. layers. The upper channel was dedicated to donor phase flow pass, while the beneath channel was used as a reservoir for stagnant acceptor solution A slide of fluorine doped tin oxide (FTO) was accommodated in the bottom of the acceptor phase channel. A thin layer of polyaniline was electrodeposited on the FTO surface to achieve the required thin film for TF-SPME. A stainless-steel wire was embedded in the donor phase channel and another wire was also attached to the FTO surface. The channels were separated by a piece of polypropylene membrane impregnated with 1-octanol and the whole chip was fixed with bolts and nuts. The driving force for the extraction was an 8 V d.c. (DC) voltage applied across the supported liquid membrane (SLM). Under the influence of the elec. field, analytes immigrated from sample towards the acceptor phase and then adsorbed on the thin film of the solid phase. Finally, the analytes were desorbed by successive movement of a desorption solvent in the acceptor phase channel followed by injection of the desorption solution to HPLC-UV. The applicability of the proposed device was demonstrated by the determination of four synthetic food dyes: Amaranth, Ponceau 4R, Allura Red, and Carmoisine, as the model analytes. The effective parameters on the efficiency of the both EME and TF-SPME were investigated. Under the optimized conditions, the microchip provided low LODs (1-10μg L-1), and a wide linear dynamic range of 10-1000μg L-1 for all analytes. The system also offered RSD values lower than 5.5% and acceptable reusability of the thin film for multiple extractions

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Applied Microbiology and Biotechnology called Characterisation of nitrilase and nitrile hydratase biocatalytic systems, Author is Brady, D.; Beeton, A.; Zeevaart, J.; Kgaje, C.; van Rantwijk, F.; Sheldon, R. A., which mentions a compound: 17190-29-3, SMILESS is N#CCC(O)C1=CC=CC=C1, Molecular C9H9NO, Name: 3-Hydroxy-3-phenylpropanenitrile.

Biocatalytic transformations converting aromatic and arylaliph. nitriles into the analogous related amide or acid were investigated. These studies included synthesis of the β-substituted nitrile 3-hydroxy-3-phenylpropionitrile, subsequent enrichment and isolation on this substrate of nitrile-degrading microorganisms from the environment, and a comparative study of enzymic reactions of nitriles by resting cell cultures and enzymes. Each biocatalyst exhibited a distinctive substrate selectivity profile, generally related to the length of the aliphatic chain of the arylaliph. nitrile and the position of substituents on the aromatic ring or aliphatic chain. Cell-free nitrilases generally exhibited a narrower substrate range than resting whole cells of Rhodococcus strains. The Rhodococcus strains all exhibited nitrile hydratase activity and converted β-hydroxy nitriles (but did not demonstrate enantioselectivity on this substrate). The biocatalysts also mediated the synthesis of a range of α-hydroxy carboxylic acids or amides from aldehydes in the presence of cyanide. The use of an amidase inhibitor permits halting the nitrile hydratase/amidase reaction at the amide intermediate.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 52287-51-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Author is Cincinelli, Raffaella; Dallavalle, Sabrina; Nannei, Raffaella; Merlini, Lucio; Penco, Sergio; Giannini, Giuseppe; Pisano, Claudio; Vesci, Loredana; Ferrara, Fabiana Fosca; Zuco, Valentina; Zanchi, Chiara; Zunino, Franco.

Atypical retinoids, or retinoid-related mols. (RRMs), represent a class of proapoptotic agents with a promising potential in the treatment of neoplastic diseases. In the present work, the synthesis and structure-activity relationship of a series of 3′-adamantan-1-yl-biphenyl-4-yl-acrylic acids substituted in ring A were studied. The synthesized compounds were evaluated for their antiproliferative activity in a human promyelocytic leukemia cell line (NB4), and in an ovarian carcinoma cell system including IGROV-1, carrying a functional wild-type p53, and a cisplatin-resistant subline, IGROV-1/Pt-1. The presence of at least one oxygenated substituent in positions 4′ or 5′ appears determinant for the antiproliferative activity. With two substituents of this kind the activity increases, particularly in the case of alkylenedioxy compounds The activation of DNA damage response as indicated by phosphorylation of H2AX histone, RPA-2 protein, and p53 at serine 15 by the most apoptotic compounds provides addnl. support to the hypothesis that the genotoxic stress is a critical event mediating apoptosis induction by compounds of this group.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pauletto, P. S.; Goncalves, J. O.; Pinto, L. A. A.; Dotto, G. L.; Salau, N. P. G. published the article 《Single and competitive dye adsorption onto chitosan-based hybrid hydrogels using artificial neural network modeling》. Keywords: competitive dye adsorption chitosan hydrogel artificial neural network modeling; Artificial neural network; Binary system; Chitosan; Competitive adsorption; Hydrogel.They researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).COA of Formula: C18H14N2Na2O8S2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:25956-17-6) here.

Chitosan-based hybrid hydrogels such as chitosan hydrogel (CH), chitosan hydrogel with activated carbon (CH-AC), scaffold-chitosan hydrogel (SCH), scaffold-chitosan hydrogel with activated carbon (SCH-AC) and scaffold-chitosan hydrogel with carbon nanotubes (SCH-CN) were synthesized, characterized and applied to adsorb Acid Blue 9 (AB) and Allura Red AC (AR) from single and simultaneous binary liquid systems. Exptl. results revealed competitive adsorption as the adsorption capacity was reduced in binary system for each dye. In addition, SCH-CN presented the highest adsorption capacity for both dyes, indicating that the modification increased the number of active sites and the functionalization with -OH groups favored the interactions with sulfonated groups of the dyes. A predictive artificial neural network (ANN) was implemented to forecast the adsorption capacity for AB and AR dyes as a function of initial molar concentration of each dye, adsorption time, porosity and mass percentage of carbonaceous material on each hydrogel. The network was trained with the Levenberg-Marquardt back-propagation optimization, and according to the high correlation coefficient (R = 0.9987) and low values of root mean square error (RMSE = 0.0119), sum of the absolute error (SAE = 0.7541) and sum of squares error (SSE = 0.0132), the best topol. was found to be 5-10-10-10-2. The ANN proved to be effective in predicting dye adsorption capacity of each hydrogel, even for the competitive adsorption, as the R values were close to unity for all simulation systems.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C9H9NO. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Syntheses with α-metalated isocyanides. 6. 2-Isocyano-1-alkanols from carbonyl compounds and α-metalated isocyanides. Author is Boell, Walter A.; Gerhart, Fritz; Nuerrenbach, Axel; Schoellkopf, Ulrich.

Lithio compounds RCH(Li)NC (I) are treated with R1COPh to give isocyano alcs. R1PhC(OH)CH(NC)R (II), where R is H or CH2CH2NMe2 and R1 is H or Me. II (R = H, R1 = Me) is converted into the formamide, MePhC(OH)CH2NHCHO. I are prepared from RCH2NC and BuLi.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

COA of Formula: C4H9Cl2N3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1H-Imidazol-2-yl)methanamine dihydrochloride, is researched, Molecular C4H9Cl2N3, CAS is 22600-77-7, about (8,9-Dihydro-7H-imidazo[1,2-c][1,3]diazepine-5-yl)cyanamide and imidazo-bicyclic homologs. Author is Buschauer, A.; Schunack, W..

The reaction of the 2-(ω-aminoalkyl)imidazoles I [n = 1, 3, 4; R, R1 = H, Me, RR1 = (CH2)4] with (PhO)2C:NCN gave imidazo[1,5-a]imidazoles, imidazo[1,2-c]diazepines and imidazo[1,2-c]diazocines II, which are similar to (7,8-dihydroimidazo[1,2-c]pyrimidin-5-yl)cyanamides with respect to their chem. and spectroscopic properties.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics