Month: April 2022

Category: pyrazoles-derivatives. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Reformatskii type additions of haloacetonitriles to aldehydes mediated by metallic nickel. Author is Inaba, Shinichi; Rieke, Reuben D..

β-Hydroxy nitriles HOCHRCH2CN [R = (un)substituted Ph, styryl, alkyl, alkenyl] were prepared by Reformatskii type addition of haloacetonitriles to aldehydes RCHO in the presence of metallic Ni (generated in situ).

After consulting a lot of data, we found that this compound(17190-29-3)Category: pyrazoles-derivatives can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Recommanded Product: 22600-77-7. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1H-Imidazol-2-yl)methanamine dihydrochloride, is researched, Molecular C4H9Cl2N3, CAS is 22600-77-7, about Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins. Author is ElHady, Ahmed K.; Abdel-Halim, Mohammad; Abadi, Ashraf H.; Engel, Matthias.

In cancer cells, kinases of the Clk family control the supply of full-length, functional mRNAs coding for a variety of proteins essential to cell growth and survival. Thus, inhibition of Clks might become a novel anticancer strategy, leading to a selective depletion of cancer-relevant proteins after turnover. On the basis of a Weinreb amide hit compound, the authors designed and synthesized a diverse set of methoxybenzothiophene-2-carboxamides, of which the N-benzylated derivative showed enhanced Clk1 inhibitory activity. Introduction of a m-fluorine in the benzyl moiety eventually led to the discovery of compound 21b (5-methoxybenzo[b]thiophene-2-carboxylic acid (3-fluorobenzyl)methylamide), a potent inhibitor of Clk1 and -4 (IC50 = 7 and 2.3 nM, resp.), exhibiting an unprecedented selectivity over Dyrk1A. Compound 21b triggered the depletion of EGFR, HDAC1, and p70S6 kinase from the cancer cells, with potencies in line with the measured GIC50 values. In contrast, the cellular effects of congener 21a (5-methoxybenzo[b]thiophene-2-carboxylic acid 3-fluorobenzylamide), which inhibited Clk1 only weakly, were substantially lower.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

COA of Formula: C2O4Sn. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Tin(II) oxalate, is researched, Molecular C2O4Sn, CAS is 814-94-8, about A new lithium diffusion model in layered oxides based on asymmetric but reversible transition metal migration. Author is Ku, Kyojin; Kim, Byunghoon; Jung, Sung-Kyun; Gong, Yue; Eum, Donggun; Yoon, Gabin; Park, Kyu-Young; Hong, Jihyun; Cho, Sung-Pyo; Kim, Do-Hoon; Kim, Hyungsub; Jeong, Eunsuk; Gu, Lin; Kang, Kisuk.

Lithium-rich layered oxides (LLOs) are considered promising cathode materials for lithium-ion batteries because of their high reversible capacity, which is attributed to the exploitation of the novel anionic redox in addition to the conventional cationic redox process. Transition metal (TM) migration, which is known to be the main cause of the voltage decay in LLOs, is now understood to also be the critical factor triggering anionic redox, although this origin is still under debate. A better understanding of the specific TM migration behavior and its effect during charge/discharge would thus enable further development of this class of materials. Herein, we demonstrate that the unique TM migration during charge/discharge significantly alters the lithium diffusion mechanism/kinetics of LLO cathodes. We present clear evidence of the much more sluggish lithium diffusion occurring during discharge (lithiation) than during charge (de-lithiation), which contrasts with the traditional lithium diffusion model based on simple topotactic lithium intercalation/deintercalation in the layered framework. The reversible but asym. TM migration in the structure, which originates from the non-equivalent local environments around the TM during the charge and discharge processes, is shown to affect the lithium mobility. This correlation between TM migration and lithium mobility led us to propose a new lithium diffusion model for layered structures and suggests the importance of considering TM migration in designing new LLO cathode materials.

After consulting a lot of data, we found that this compound(814-94-8)COA of Formula: C2O4Sn can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 17190-29-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Synthetic application of cyanoaminosilanes as azomethine ylide equivalents. Author is Padwa, Albert; Chen, Yon Yih; Dent, William; Nimmesgern, Hildegard.

A series of α-cyanoaminosilanes acted as azomethine ylide equivalent Treatment of these compounds with AgF in the presence of electron-deficient alkynes and olefins gives substituted pyrroles and pyrrolidines in high yield. Me3SiCH2N(CH2Ph)CH2CN (I) undergoes stereospecific cycloaddition with di-Me fumarate and maleate. The stereospecificity of the reaction is consistent with a concerted cycloaddition reaction. The cycloaddition behavior of an unsym. substituted α-cyanosilylamine with MeO2CCCH was also examined and found to react with high overall regioselectivity. The synthetic utility of cyanoaminosilanes as azomethine ylide equivalent was demonstrated by the preparation of a Reniera isoindole alkaloid (II). The key step in the synthesis involved the reaction of 2-methyl-3-methoxyquinone with I in the presence of AgF to give 2,5-dimethyl-6-methoxyisoindole-4,7-dione in good yield.

After consulting a lot of data, we found that this compound(17190-29-3)Application of 17190-29-3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Staples, Jack W.; Stine, Jessica M.; Maki-Lohiluoma, Eero; Steed, Emily; George, Kathleen M.; Thompson, Charles M.; Woodahl, Erica L. published the article 《Food dyes as P-glycoprotein modulators》. Keywords: allurared carmoisine ponceau4R sunset quinolone yellow tartrazine AtPase Pglycoprotein; Drug transporter; Food dye; P-glycoprotein.They researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).SDS of cas: 25956-17-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:25956-17-6) here.

The drug transporter P-glycoprotein (P-gp) is often investigated in drug-interaction studies because the activity is modulated by a wide variety of xenobiotics including drugs, herbal products, and food components. In this study, we tested six common arylsulfonate food dyes-allura red, carmoisine, ponceau 4R, quinolone yellow, sunset yellow, and tartrazine-as activators and inhibitors of P-gp activity in vitro. The dyes were studied as P-gp activators by measuring ATPase activity in P-gp-expressing membranes. Compared to verapamil, a known activator of P-gp, the six food dyes showed no stimulatory activity. The potential for these six food dyes to act as P-gp inhibitors was tested in an intracellular efflux assay with P-gp-expressing cells. Compared to GF120918, a known P-gp inhibitor, there was no inhibitory activity for these six food dyes. The six food dyes tested do not interact with P-gp in vitro and, therefore, are unlikely cause clin. drug-food dye interactions. Further investigation is necessary to determine whether these food dyes could interact with other drug transporters.

After consulting a lot of data, we found that this compound(25956-17-6)SDS of cas: 25956-17-6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Recommanded Product: 52287-51-1. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about 6-(4-Benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D4 receptors. Author is Hodgetts, Kevin J.; Kieltyka, Andrzej; Brodbeck, Robbin; Tran, Jennifer N.; Wasley, Jan W. F.; Thurkauf, Andrew.

A series of novel 6-(4-benzylpiperazin-1-yl)benzodioxanes were prepared and screened at selected dopamine receptor subtypes. 6-(4-[4-Chlorobenzyl]piperazin-1-yl)benzodioxane had high affinity and selectivity for the D4 dopamine receptor subtype and was identified as a D4 antagonist via its attenuation of dopamine-induced GTPγ35S binding at the D4 receptor.

After consulting a lot of data, we found that this compound(52287-51-1)Recommanded Product: 52287-51-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 17190-29-3, is researched, Molecular C9H9NO, about Direct Catalytic Aldol-Type Reactions Using RCH2CN, the main research direction is beta hydroxynitrile preparation; copper catalyst trimethylsilylacetonitrile alkyl nitrile aldehyde ketone; phosphine ligand copper catalyzed addition alkyl nitrile aldehyde ketone; triethoxysilyl fluoride reagent copper catalyzed addition trimethylsilylacetonitrile aldehyde ketone; enantioselective addition acetonitrile trimethylsilylacetonitrile aldehyde copper catalyst nonracemic binaphthylphosphine; direct catalytic aldol addition reaction nitrile.Synthetic Route of C9H9NO.

β-Hydroxynitriles are prepared from either trimethylsilylacetonitrile or from alkyl nitriles in the presence of copper catalysts; in the presence of nonracemic ligands, the copper-catalyzed addition of acetonitrile or trimethylsilylacetonitrile yields nonracemic β-hydroxynitriles in moderate enantioselectivities and yields. α-Unsubstituted-β-hydroxynitriles are prepared in 75-100% yields by the addition of trimethylsilylacetonitrile to aldehydes and ketones in the presence of copper fluoride and a stoichiometric quantity of triethoxysilyl fluoride; the reaction is effective for aryl ketones and aldehydes, alkyl and cycloalkyl aldehydes, and α,β-unsaturated aldehydes and ketones. α-Unsubstituted- and α-substituted-β-hydroxynitriles are prepared in 71-95% yields by the addition of alkyl nitriles RCH2CN (R = H, Me, Et) to aldehydes in the presence of alk. metal-free copper (I) tert-butoxide (generated by addition of tert-butanol to mesitylcopper) and a phosphine such as dppe; α-substituted-β-hydroxynitriles are generated with moderate to low stereoselectivities for the syn isomers. Hydrolysis of the nitriles to carboxylic acids with base allows the addition of nitriles to aldehydes and ketones to function as a catalytic surrogate for the aldol addition reaction of esters to ketones and aldehydes. In the presence of nonracemic diphosphine ligands and either copper (I) tert-butoxide or copper (I) fluoride and triethoxysilyl fluoride, either acetonitrile or trimethylsilylacetonitrile, resp., add enantioselectively to aldehydes or ketones to give β-hydroxynitriles in 48-70% yields and in 47-53% ee.

After consulting a lot of data, we found that this compound(17190-29-3)Synthetic Route of C9H9NO can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Fluoro-1H-indole-3-carboxylic acid, is researched, Molecular C9H6FNO2, CAS is 23077-42-1, about Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure-Activity Relationships and Membrane Targeting Properties, the main research direction is antimycobacterial membrane targeting indole preparation structure activity.Formula: C9H6FNO2.

Antibacterials that disrupt cell membrane function have the potential to eradicate “”persister”” organisms and delay the emergence of resistance. Here we report the antimycobacterial activities of 4-fluoro and 6-methoxyindoles bearing a cationic amphiphilic motif represented by a lipophilic n-octyl side chain at position 1 and a pos. charged azepanyl or 1,4-dioxa-8-azaspiro[4.5]decane moiety at position 3. These analogs exhibited balanced profiles of potency (Mycobacterium bovis BCG, M tuberculosis H37Rv), selective activity, solubility, and metabolic stability. Bacteriol. mechanism of action investigations on a representative analog revealed cell membrane permeabilization and depolarization in M bovis BCG. These membrane-related changes preceded cell death indicating that the loss in membrane integrity was not an epiphenomenon. Bactericidal activity was observed against both growing and nongrowing mycobacterial cultures. The analog also upregulated cell envelope stress-inducible promoters piniBAC and pclgR, implicating the involvement of envelope-related targets in its mode of action.

After consulting a lot of data, we found that this compound(23077-42-1)Formula: C9H6FNO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Quality Control of Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Using High-Throughput Screening to Evaluate Perturbations Potentially Linked to Neurobehavioral Outcomes: A Case Study Using Publicly Available Tools on FDA Batch-Certified Synthetic Food Dyes. Author is Pham, Nathalie; Miller, Mark D.; Marty, Melanie.

There is growing evidence from human and animal studies indicating an association between exposure to synthetic food dyes and adverse neurobehavioral outcomes in children. However, data gaps persist for potential mechanisms by which the synthetic food dyes could elicit neurobehavioral impacts. We developed an approach to evaluate seven US FDA-batch-certified food dyes using publicly available high-throughput screening (HTS) data from the US EPA’s Toxicity Forecaster to assess potential underlying mol. mechanisms that may be linked to neurol. pathway perturbations. The dyes were screened through 270 assays identified based on whether they had a neurol.-related gene target and/or were mapped to neurodevelopmental processes or neurobehavioral outcomes, and were conducted in brain tissue, targeted specific hormone receptors, or targeted oxidative stress and inflammation. Some results provided support for neurol. impacts found in human and animal studies, while other results showed a lack of correlation with in vivo findings. The azo dyes had a range of activity in assays mapped to G-protein-coupled receptors and were active in assays targeting dopaminergic, serotonergic, and opioid receptors. Assays mapped to nuclear receptors (androgen, estrogen, and thyroid hormone) also exhibited activity with the food dyes. Other mol. targets included the aryl hydrocarbon receptor, acetylcholinesterase, and monoamine oxidase. The Toxicol. Prioritization Index tool was used to visualize the results of the Novascreen assays. Our results highlight certain limitations of HTS assays but provide insight into potential underlying mechanisms of neurobehavioral effects observed in in vivo animal toxicol. studies and human clin. studies.

After consulting a lot of data, we found that this compound(25956-17-6)Quality Control of Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 25956-17-6, is researched, Molecular C18H14N2Na2O8S2, about Modeling of fixed-bed dye adsorption using response surface methodology and artificial neural network, the main research direction is modeling fixed bed polyurethane chitosan foam adsorption red dye; artificial neural network modeling dye foam adsorption red dye; response surface methodol modeling red 40 dye adsorption; adsorption wastewater treatment red 40 dye polyurethane chitosan foam.Recommanded Product: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate.

Artificial neural network (ANN) and response surface methodol. (RSM) models were used to analyze the fixed bed adsorption of food, drug, and cosmetic (FD&C) red 40 dye by polyurethane/chitosan foam (PU/CS foam). The adsorbent was prepared and characterized. The effect of process variables (flow rate, bed height) were examined on two levels by RSM. Break-through curves were used as a training dataset for ANN. ANN was customized with 10 neurons in the hidden layer using the hyperbolic tangent sigmoid transfer function as activation function and the linear transfer function in the output layer. The optimal range of bed operation was 5-6 cm bed height and 15-17.05 mL/min flow rate. Column exptl. adsorption capacity values were 44.3-108.1 mg/g, and were compared with ANN and RSM modeling results. ANN predicted exptl. data with greater accuracy than RSM. Coefficient of determination values were 0.9911 for ANN and 0.8853 for RSM. Various error functions tested for ANN and RSM model-predicted and exptl. values demonstrated the better applicability and efficiency of the ANN model. PU/CS foam proved a promising, low cost adsorbent with excellent potential to remove FD&C red 40.

After consulting a lot of data, we found that this compound(25956-17-6)Recommanded Product: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics