Month: April 2022

Quality Control of Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Comparison between Allura Red dye discoloration by activated carbon and azo bacteria strain. Author is Herrera-Garcia, Sabrina; Aguirre-Ramirez, Marisela; Torres-Perez, Jonatan.

Azo dyes are extensively used in different industries areas, such as Allura Red (R-40). Previous studies have proven its carcinogenic and mutagenic properties. For the removal of this type of emerging pollutant from effluents, tertiary treatment techniques such as activated charcoal are used. Alternatively, the use of bacteria is preferred because of its quick discoloration processes. The aim of the present investigation is to compare the efficiency removal of R-40 from aqueous media by a physicochem. process and a biol. one. The sorption kinetics of 10 ppm of R-40 was carried out with the use of activated charcoal based on walnut shells in water. Moreover, Pseudomonas aeruginosa and Bacillus subtilis stains were used sep. to decolorize nutrient broth media supplemented with 50 ppm of R-40. The activated carbon was capable to remove 99.87% of R-40 at 264 h, while the bacterial strains decolorized 92.13% (P. aeruginosa) and 88.21% (B. subtilis), resp., under microaerophilic conditions after 168 h. Therefore, both process strategies, physicochem. and biol. rapprochements, were able to remove the dye from aqueous media. R-40 was not cytotoxic to used strains, besides gram-pos. either neg. bacteria could be applied to turn over this azo dye in short term. Combination of both approaches may be implemented in tandem architecture.

The article 《Comparison between Allura Red dye discoloration by activated carbon and azo bacteria strain》 also mentions many details about this compound(25956-17-6)Quality Control of Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 1300746-79-5. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). Author is Rai, Ganesha; Brimacombe, Kyle R.; Mott, Bryan T.; Urban, Daniel J.; Hu, Xin; Yang, Shyh-Ming; Lee, Tobie D.; Cheff, Dorian M.; Kouznetsova, Jennifer; Benavides, Gloria A.; Pohida, Katie; Kuenstner, Eric J.; Luci, Diane K.; Lukacs, Christine M.; Davies, Douglas R.; Dranow, David M.; Zhu, Hu; Sulikowski, Gary; Moore, William J.; Stott, Gordon M.; Flint, Andrew J.; Hall, Matthew D.; Darley-Usmar, Victor M.; Neckers, Leonard M.; Dang, Chi V.; Waterson, Alex G.; Simeonov, Anton; Jadhav, Ajit; Maloney, David J..

The authors report the discovery and medicinal chem. optimization of a novel series of pyrazole-based inhibitors of human lactate dehydrogenase (LDH). Utilization of a quant. high-throughput screening paradigm facilitated hit identification, while structure-based design and multiparameter optimization enabled the development of compounds with potent enzymic and cell-based inhibition of LDH enzymic activity. Lead compounds such as 63 exhibit low nM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate production, and inhibition of glycolysis in MiaPaCa2 pancreatic cancer and A673 sarcoma cells. Moreover, robust target engagement of LDHA by lead compounds was demonstrated using the cellular thermal shift assay (CETSA), and drug-target residence time was determined via SPR. Anal. of these data suggests that drug-target residence time (off-rate) may be an important attribute to consider for obtaining potent cell-based inhibition of this cancer metabolism target.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Computed Properties of C13H23NO4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-tert-Butyl 2-ethyl piperidine-1,2-dicarboxylate, is researched, Molecular C13H23NO4, CAS is 362703-48-8, about New short and general synthesis of three key Maillard flavour compounds: 2-Acetyl-1-pyrroline, 6-acetyl-1,2,3,4-tetrahydropyridine and 5-acetyl-2,3-dihydro-4H-1,4-thiazine. Author is Deblander, Jurgen; Van Aeken, Sam; Adams, An; De Kimpe, Norbert; Abbaspour Tehrani, Kourosch.

A general synthetic route was developed to obtain 3 key Maillard flavor compounds, namely 2-acetyl-1-pyrroline, 6-acetyl-1,2,3,4-tetrahydropyridine, and 5-acetyl-2,3-dihydro-4H-1,4-thiazine. The key step in the process is the methylenation reaction of azaheterocyclic carboxylic esters by dimethyltitanocene, giving rise to intermediate vinyl ethers which can be considered stable precursors for the title compounds Simple acidic treatment of these precursors can release the characteristic Maillard flavor compounds

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: 17190-29-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Efficient lipase-catalyzed kinetic resolution and dynamic kinetic resolution of β-hydroxy nitriles. A route to useful precursors for γ-amino alcohols. Author is Pamies, Oscar; Backvall, Jan-E..

An efficient kinetic resolution of racemic β-hydroxy nitriles was performed via Candida antarctica lipase (N-435)-catalyzed transesterification. A variety of racemic alkyl, aryl, and aryloxymethyl substituted β-hydroxy nitriles was efficiently transformed to the corresponding enantiomerically pure acetates (ee >99% and conversion = 50%) with E values from 40 to >1000. The combination of the enzymic kinetic resolution with a ruthenium-catalyzed alc. racemization led to a dynamic kinetic resolution (ee’s up to 99%, yields up to 85%).

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Category: pyrazoles-derivatives. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Development and validation of the HPLC-DAD method for the quantification of 16 synthetic dyes in various foods and the use of liquid anion exchange extraction for qualitative expression determination.

Synthetic dyes can cause many health problems, and their use as food additives is rigorously regulated worldwide. Two methods for the determination of synthetic dyes in food are described in this article. The visual qual. expression method was based on the extraction of synthetic dyes using a liquid anion exchanger (0.01 M solution of trioctylmethylammonium chloride in chloroform). Using this reagent, an optimal transition of 15 anionic synthetic dyes from the aqueous to the organic phase was achieved (R > 99.8%). It was applicable for testing food that must not contain synthetic dyes (wines, juices, etc.) in a very short time (5-10 min). In the case of coloring of the organic phase, identification and quantification was carried out using the HPLC-DAD method described. The rapid and simple method allows for simultaneous determination of 16 synthetic dyes from all food types. The LOD and LOQ ranged from 0.026 to 0.086μg mL-1 and from 0.077 to 0.262μg mL-1 resp., and recovery was 83.7-107.5%. Hypothesis: anionic synthetic dyes have hydrophobic properties, as a result they are retained on the non-polar stationary phase of the chromatog. column and are easily extracted from aqueous solutions by liquid anion exchangers.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Walther, Martin; Matterna, Madlen; Juran, Stefanie; Faehnemann, Silke; Stephan, Holger; Kraus, Werner; Emmerling, Franziska published the article 《Imidazole-containing bispidine ligands: synthesis, structure and Cu(II) complexation》. Keywords: copper imidazole bispidine complex preparation crystal structure.They researched the compound: (1H-Imidazol-2-yl)methanamine dihydrochloride( cas:22600-77-7 ).Category: pyrazoles-derivatives. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:22600-77-7) here.

The preparation and characterization of tris-pyridyl bispidine (3,7-diazabicyclo[3.3.1]nonane) derivatives with benzimidazole and imidazole donor groups at the N-3 position of the bispidine skeleton and their copper(II) complexes are reported. The impact of the hetaryl substituents on the configurational isomerism of piperidones and their corresponding bispidones was studied by NMR spectroscopy, revealing the exclusive appearance in the enol form for the piperidones in solution and the trans-configuration regarding the two pyridyl substituents, as well as the sole formation of the unsym. exo-endo isomers for the corresponding bispidones. Thus, the bispidones are preorganized ligands for building pentacoordinated complexes, confirmed by the preparation and characterization of the corresponding Cu(II) complexes. Of the di-pyridyl piperidones with benzimidazole and imidazole substituents, and of the Cu(II) complex of the benzimidazole-containing bispidone, crystals have become available for the anal. by x-ray diffraction, showing that the piperidones form the enol tautomers also in the solid state.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 17190-29-3, is researched, Molecular C9H9NO, about Unexpected Stereorecognition in Nitrilase-Catalyzed Hydrolysis of β-Hydroxy Nitriles, the main research direction is nitrile hydroxy preparation enantioselective enzymic hydrolysis nitrilase; carboxylic acid hydroxy aryl asym synthesis.Recommanded Product: 17190-29-3.

Biocatalytic enantioselective hydrolysis of β-hydroxy nitriles RCH(OH)CH2CN (R = Ph, 4-FC6H4, 2-MeOC6H4, 2,4-Cl2C6H3, etc.) to the corresponding (S)-enriched β-hydroxy carboxylic acids RCH(OH)CH2COOH has been achieved for the first time by an isolated nitrilase bll6402 from Bradyrhizobium japonicum USDA110. This offers a new “”green”” approach to optically pure β-hydroxy nitriles and β-hydroxy carboxylic acids. The observed remote stereorecognition is surprising because this nitrilase shows no enantioselectivity for the hydrolysis of α-hydroxy nitriles such as mandelonitrile.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ) is researched.Related Products of 25956-17-6.Khan, Menhad; Khan, Adnan; Khan, Hammad; Ali, Nisar; Sartaj, Seema; Malik, Sumeet; Ali, Nauman; Khan, Hamayun; Shah, Sumaira; Bilal, Muhammad published the article 《Development and characterization of regenerable chitosan-coated nickel selenide nano-photocatalytic system for decontamination of toxic azo dyes》 about this compound( cas:25956-17-6 ) in International Journal of Biological Macromolecules. Keywords: chitosan nickel selenide toxic azo dye photocatalytic decontamination; Chitosan; Degradation; Nickel selenide; Organic pollutants; Photocatalyst; Reusability. Let’s learn more about this compound (cas:25956-17-6).

In this investigation, chitosan-coated nickel selenide nano-photocatalyst (CS-NiSe) was successfully prepared through the chem. reduction method. FTIR spectroscopy confirmed the synthesis of CS-NiSe nano-photocatalyst. Further, XRD anal. exhibited a monoclinic crystalline phase of photocatalyst with a crystallite size of 32 nm based on Scherer’s equation. The SEM micrographs showed that the photocatalyst has an average particle size of 60 nm. The bandgap of CS-NiSe was (2.85 eV) in the visible region of the spectrum. Due to this reason, the CS-NiSe was applied under solar light illumination for the photocatalytic activity of Erythrosine and Allura red dyes. The CS-NiSe presented the highest degradation efficiency of 99.53% for Erythrosine dye in optimized exptl. conditions of 100 min at 30°C, 30 ppm concentration, pH 5.0, and 0.14 g catalyst dose. For Allura red dye, a high degradation of 96.12% was attained in 120 min at pH 4.0, 100 ppm initial dye concentration, 35°C temperature, and 0.1 g catalyst dose. The CS-NiSe showed excellent degradation efficiency and reduced to (95% for Erythrosine and 91% for Allura red dye) after five consecutive batches. Moreover, the statistical and neural network modeling anal. showed the significant influence of all studied variables on dyes degradation performance. The results demonstrated that CS-NiSe exhibited excellent photocatalytic performances for Erythrosine and Allura red dyes and could be a better photocatalyst for removing these dyes from industrial effluents.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Category: pyrazoles-derivatives. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Addition of α-Halo-substituted Carbonitriles to Aldehydes and Ketones in the Presence of Iron Pentacarbonyl.

Halo-substituted carbonitriles in the presence of iron pentacarbonyl react with aldehydes and ketones by Reformatsky reaction type. In contract to halo-substituted esters the nitriles are considerably more reactive toward ketones than aldehydes. At the same time the structure and yield of products obtained from both nitriles and esters are strongly and similarly affected by the character of the para-substituents in the benzaldehyde. Thus, Fe(CO)5-mediated reaction of ICH2CN with 2-hexanone in C6H6 gave 70% 3-hydroxy-3-methylenanthonitrile.

After consulting a lot of data, we found that this compound(17190-29-3)Category: pyrazoles-derivatives can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Preparation of β-hydroxyesters from isoxazolines. A selective Ni0bpy-catalyzed electrochemical method, published in 2003-11-03, which mentions a compound: 17190-29-3, Name is 3-Hydroxy-3-phenylpropanenitrile, Molecular C9H9NO, Quality Control of 3-Hydroxy-3-phenylpropanenitrile.

An electrocatalytic method for the reductive N-O cleavage of isoxazolines I [R1 = Ph; R2 = H; R3 = OMe, Br; R1R2 = (CH2)4; R3 = OMe], is described. Ni0bpy, generated in situ, was used to promote selective ring opening of I. DMF and NaI were used as solvent and supporting electrolyte resp., and β-hydroxyesters were obtained in high yields, after acid hydrolysis. β-Hydroxynitriles were also identified as side products.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics