Month: March 2022

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Bioorganic & Medicinal Chemistry Letters called 5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors, Author is Xu, Guozhang; Du, Fuyong; Kuo, Gee-Hong; Xu, June Zhi; Liang, Yin; Demarest, Keith; Gaul, Michael D., which mentions a compound: 52287-51-1, SMILESS is BrC1=CC=C2OCCOC2=C1, Molecular C8H7BrO2, SDS of cas: 52287-51-1.

(2S,3R,4R,5S,6R)-2-Aryl-5,5-difluoro-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diols and (2S,3R,4R,5S,6R)-2-aryl-5-fluoro-5-methyl-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diols were discovered as dual inhibitors of sodium glucose co-transporter proteins (e.g. SGLT1 and SGLT2) through rational drug design, efficient synthesis, and in vitro and in vivo evaluation. Compound I demonstrated potent dual inhibitory activities (IC50 = 96 nM for SGLT1 and IC50 = 1.3 nM for SGLT2). It showed robust inhibition of blood glucose excursion in an oral glucose tolerance test (OGTT) in Sprague Dawley (SD) rats when dosed at both 1 mg/kg and 10 mg/kg orally. It also demonstrated postprandial glucose control in db/db mice when dosed orally at 10 mg/kg.

From this literature《5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors》,we know some information about this compound(52287-51-1)SDS of cas: 52287-51-1, but this is not all information, there are many literatures related to this compound(52287-51-1).

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 25956-17-6, is researched, SMILESS is O=S(C1=CC=C2C(/N=N/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+], Molecular C18H14N2Na2O8S2Journal, Microchemical Journal called Extraction and determination of synthetic food dyes using tetraalkylammonium based liquid-liquid extraction, Author is Smirnova, Svetlana V.; Lyskovtseva, Kristina A.; Pletnev, Igor V., the main research direction is synthetic food dye tetraalkylammonium liquid extraction ionic preconcentration analysis.HPLC of Formula: 25956-17-6.

Tetraalkylammonium based liquid-liquid biphasic systems (employing room-temperature ionic liquids tetraoctylammonium N-lauroylsarcosinate, TOALS, and tetrahexylammonium dihexylsulfosuccinate, THADHSS, as well as tetrahexylammonium bromide, THABr) were used for liquid-liquid extraction of synthetic food dyes followed by spectrophotometric determination Dyes studied are Allura Red AC, Red 2G, Azorubine, and Fast Green FCF (all anionic). Both extraction to pre-synthesized ILs and to ILs formed in situ was studied. The effects of pH, ionic liquid volume, dye concentration, time of extraction/centrifugation and other factors were investigated and optimum conditions were established. Dispersive liquid-liquid microextraction (DLLME) in situ is based on a metathesis between two salts which are suppliers of cations and anions of IL. It was found that efficiency of in situ DLLME with the studied ILs strongly depends on the ratio between cation and anion suppliers (THABr and NaDHSS/ NaLS, resp.) and drops sharply if an excess of anion supplier is used. Liquid-liquid extraction system using THABr was found to be superior for preconcentration and spectrophotometric determination of Allura Red AC and Azorubine in food samples. Under optimal conditions, recovery of all analytes was nearly 100%. Linear calibration curves in the range of 0.05-4.95 mg L-1 for Allura Red AC and 0.05-2.00 mg L-1 for Azorubine were obtained. Detection limits based on 3Sb were 0.004 and 0.006 mg L-1 for Allura Red and Azorubine, resp. The proposed method was applied to determination of Allura Red and Azorubine in beverage and Easter egg coloring set.

From this literature《Extraction and determination of synthetic food dyes using tetraalkylammonium based liquid-liquid extraction》,we know some information about this compound(25956-17-6)HPLC of Formula: 25956-17-6, but this is not all information, there are many literatures related to this compound(25956-17-6).

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Humidity compensation based on power-law response for MOS sensors to VOCs, published in 2021-05-01, which mentions a compound: 814-94-8, Name is Tin(II) oxalate, Molecular C2O4Sn, Formula: C2O4Sn.

The compensation model for humidity is proposed for Metal oxide semiconductor (MOS) sensors to respond to volatile organic compounds (VOCs) vapor. There are four frequently-used sensors were investigated for the detection of three typical VOCs, namely, acetone, ethanol and methanol. In this study, water vapor was treated as a reactant involved in the response, then a model is proposed based on the power law response. As the resistance of sensor and humidity enter the model, the detected gas concentration will be output. The effect of model is well verified on the exptl. system. Even the model was applied to electronic nose to improve the recognition results. It indicates that our method is of great value to system that needs to remove the interference of water vapor.

From this literature《Humidity compensation based on power-law response for MOS sensors to VOCs》,we know some information about this compound(814-94-8)Formula: C2O4Sn, but this is not all information, there are many literatures related to this compound(814-94-8).

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Facile synthesis of an organic-inorganic nanocomposite, PEG-silica, by sol-gel method; its characterization and application as an efficient catalyst in regioselective nucleophilic ring opening of epoxides: Preparation of β-azido alcohols and β-cyanohydrins, the main research direction is polyethyleneglycol silica hybrid catalyst regioselective nucleophilic ring opening epoxide; soluble gel method polyethyleneglycol silica hybrid preparation catalyst; cyanohydrin azido alc preparation polyethyleneglycol silica hybrid catalyst.Related Products of 17190-29-3.

The sol-gel method was used for the synthesis of a PEG-silica hybrid. In order to introduce PEG into the cavities of silica gel, first, the bis(3-trimethoxysilylpropyl)-polyethylene glycol precursor was synthesized by the reaction of (3-chloropropyl)trimethoxysilane with alkoxides formed on the PEG terminals. The organic-inorganic hybrid silica was then synthesized by hydrolysis and polycondensation of the precursor under mild acidic conditions. The characteristics results of FT-IR, XRD and TGA confirmed the coexistence of silica and PEG networks. The catalytic ability of this heterogeneous catalyst to the regioselective ring opening of epoxides by azide and cyanide anions in H2O was also investigated.

From this literature《Facile synthesis of an organic-inorganic nanocomposite, PEG-silica, by sol-gel method; its characterization and application as an efficient catalyst in regioselective nucleophilic ring opening of epoxides: Preparation of β-azido alcohols and β-cyanohydrins》,we know some information about this compound(17190-29-3)Related Products of 17190-29-3, but this is not all information, there are many literatures related to this compound(17190-29-3).

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Easy direct stereo- and regioselective formation of β-hydroxy nitriles by reaction of 1,2-epoxides with potassium cyanide in the presence of metal salts.Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile.

The metal salt-catalyzed ring opening of epoxides with KCN in MeCN gave regioselectively and stereoselectively β-hydroxy nitriles. The ring opening reaction is regioselective with attack of the nucleophile only on the sterically less hindered carbon. Treatment of (±)-1-hexyloxirane with KCN/LiCLO4 in MeCN gave 95% C5H11CH(OH)CH2CH2CN (97.0% attack at the β-carbon and 1.8% attack at the α-carbon). The ring opening reaction is anti-stereoselective, whereby only the trans isomer of the β-hydroxy nitriles were formed. Ring opening of (+)-1,2-epoxycyclohexane gave 96% trans-3-hydroxy-1-cyclohexanecarbonitrile. With styrene oxide attack of the nucleophile occurred also on the more substituted benzylic carbon.

From this literature《Easy direct stereo- and regioselective formation of β-hydroxy nitriles by reaction of 1,2-epoxides with potassium cyanide in the presence of metal salts》,we know some information about this compound(17190-29-3)Recommanded Product: 3-Hydroxy-3-phenylpropanenitrile, but this is not all information, there are many literatures related to this compound(17190-29-3).

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Rational design of pincer-nickel complexes for catalytic cyanomethylation of benzaldehyde: A systematic DFT study.Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.

The current study dwells upon the efforts to computationally probe a phosphine-free pincer-nickel complex that would demonstrate an efficiency better than the reported phosphine-based pincer-nickel complex (iPr2POCNEt2)Ni(CH2CN) for cyanomethylation reaction. For this purpose, the mechanism of cyanomethylation of benzaldehyde was studied quantum mech. for a series of 11 pincer-nickel complexes. The energetics of various intermediates and transition states involved in the catalytic cycle for each catalyst was compared with the corresponding energetics of the Miller′s catalyst (iPr2POCNEt2)Ni(CH2CN) that is reported to accomplish the cyanomethylation at room temperature While pincer complexes (iPr4NNN)Ni(CH2CN) and (iPr4NCN)Ni(CH2CN) containing strong σ-donating amines were found to fare poorly, pincer-nickel complexes (iPr2NCN)Ni(CH2CN) and (dmPheboxNCN)Ni(CH2CN) based on weaker σ-donating imines had energetics more favorable than the reported efficient catalyst (iPr2POCNEt2)Ni(CH2CN). While strong trans-influencing C as the pincer central atom was found to be pivotal for lowering the cyanomethylation kinetics, presence of a poor trans-influencing N proved to be detrimental on the overall energetics.

There is still a lot of research devoted to this compound(SMILES：N#CCC(O)C1=CC=CC=C1)Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile, and with the development of science, more effects of this compound(17190-29-3) can be discovered.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chiral biphenyl diphosphines for asymmetric catalysis: stereoelectronic design and industrial perspectives, published in 2004-04-20, which mentions a compound: 52287-51-1, mainly applied to chiral biphenyl diphosphine nonracemic preparation ligand asym hydrogenation; SYNPHOS nonracemic preparation; DIFLUORPHOS nonracemic preparation; enantioselectivity hydrogenation ruthenium bidentate diphosphine ligand steric electronic effect; mol structure hydridochlororuthenium complex methyl acetoacetate DIFLUORPHOS; bite angle calculated bidentate diphosphine ligand; carbonyl stretching frequency carbonylchlororhodium complex bidentate diphosphine ligand, Recommanded Product: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine.

Both enantiomers of the chiral diphosphines I (SYNPHOS) and II (DIFLUORPHOS) are prepared on multigram scales; the electronic and steric characteristics of I and II and of rhodium complexes derived from them are determined, compared with previous diphosphine catalysts, and correlated with their activities and enantioselectivities in the hydrogenation of ketones and olefins. I and II are prepared in five steps from 6-bromo-2,3-dihydro-1,4-benzodioxane and 5-bromo-2,2-difluorobenzodioxole, resp.; lithium-metal exchange and addition to a phosphoryl or phosphinyl chloride followed by oxidation to yield phosphine oxides, regioselective lithiation and iodination, Ullman coupling of the aryl iodides, resolution (either by acid-base resolution with di-O-benzoyl-tartaric acid or by chiral HPLC), and reduction of the phosphine oxides yields I and II in 38% and 33% overall yield, resp. The bite angles of I and II are compared to those of other common diphosphine ligands such as BINAP and MeO-BIPHEP. The structure of diastereomeric chlorohydridoruthenium complexes of (S)-II with Me acetoacetate is determined The C-O stretching frequencies of chloro(carbonyl)rhodium diphosphine complexes containing I, II, BINAP, and MeO-BIPHEP are determined as a measure of the electronic demands of the diphosphine ligands. β-Keto ester, α-keto ester, 1,3-diketone, ketone, and olefin substrates are hydrogenated in the presence of nonracemic I, II, BINAP, and MeO-BIPHEP and bis(η3-methallyl)(η4-1,5-cyclooctadienyl)ruthenium; the enantioselectivities are correlated with the steric and electronic properties of the ligands. The stereoelectronic features of the ligand and the substrate deeply influence the enantioselectivities obtained in asym. hydrogenation; whereas the steric and electronic factors for I (as in other diphosphines) correlate well, the bite angle of II does not correlate to its electronic effects in asym. hydrogenation reactions, leading to complementary hydrogenation selectivities for ligands I and II.

There is still a lot of research devoted to this compound(SMILES：BrC1=CC=C2OCCOC2=C1)Recommanded Product: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, and with the development of science, more effects of this compound(52287-51-1) can be discovered.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Unified chromatography – Mass spectrometry as a versatile tool for determination of food dyes, the main research direction is unified chromatog mass spectrometry food dye; Nonpolar dyes; Subsidiary colors; Sulfonated dyes; Supercritical fluid chromatography.SDS of cas: 25956-17-6.

Unified chromatog. with mass spectrometric detection was assessed for determination of food dyes. Nineteen substances representing azo, triphenylmethane, xanthone, indigoid, quinoline and polyene classes covering an unprecedented range from nonpolar β-Carotene (logD 13.6) to ionic Tartrazine (logD -7.5) were analyzed simultaneously. The dyes were separated in a single exptl. run by an 18-min gradient elution from 98% CO2 to 100% aqueous-methanolic modifier on a diol column. Isomeric substances were resolved, and Isatin Sulfonic acid was detected as a degradation product of Indigo Carmine. Mobile phase properties reproducibly changed from supercritical to liquid state ensuring stable retention times (inter-day RSD<0.5%). Quant. anal. of sports drinks after straightforward 10- or 25-fold dilution with DMSO confirmed the method applicability to real-life samples. Sufficient limits of detection (typically 0.025 mg L-1 in processed samples, equivalent to 0.25 mg L-1 in drink) and a wide linear range (typically 0.5-50 mg L-1 or 1.3-125 mg L-1 in drink for 10x or 25x dilution, resp.) were demonstrated during validation. A comparison of method performance with competitive liquid chromatog. procedures is also provided. Unified chromatog. is a promising tool for comprehensive multiclass anal. of dyes in the context of food safety. There is still a lot of research devoted to this compound(SMILES：O=S(C1=CC=C2C(/N=N/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+])SDS of cas: 25956-17-6, and with the development of science, more effects of this compound(25956-17-6) can be discovered.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C18H14N2Na2O8S2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Facile preparation of nano-g-C3N4/UiO-66-NH2 composite as sorbent for high-efficient extraction and preconcentration of food colorants prior to HPLC analysis. Author is Zhang, Xiaowan; Yang, Yixin; Qin, Peige; Han, Lizhen; Zhu, Wenli; Duan, Shaofeng; Lu, Minghua; Cai, Zongwei.

In this work, the nano-g-C3N4/UiO-66-NH2 composite was prepared by one-step solvothermal method. The as-prepared composite was characterized by SEM, Brunner-Emmet-Teller measurement, energy dispersive spectrometer, X-ray diffraction, and Fourier transform IR spectroscopy. By using nano-g-C3N4/UiO-66-NH2 composite as sorbent, a dispersive solid-phase extraction coupled with high-performance liquid chromatog. was developed to sensitive anal. of food colorants including tartrazine, amaranth, carmine, sunset yellow, allura red and bright blue. The experiment parameters including the amount of sorbent, adsorption time, the pH of adsorption solution, desorption time, desorption solvent, the pH of desorption solution as well as the proportion between desorption solvent and buffer solvent were investigated. Under the optimized conditions, the limits of detection (S/N = 3) and limits of quantitation (S/N = 10) were determined in the ranges of 0.08-0.8 and 0.2-2.0 ng/mL, resp. With the developed sample pretreatment method, carmine and brilliant blue were determined from blueberry juice by HPLC-DAD. The contents were calculated as1.53μg/mL and 0.17μg/mL, resp.

There is still a lot of research devoted to this compound(SMILES：O=S(C1=CC=C2C(/N=N/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+])Formula: C18H14N2Na2O8S2, and with the development of science, more effects of this compound(25956-17-6) can be discovered.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Recommanded Product: 25956-17-6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Effective adsorption of dyes on an activated carbon prepared from carboxymethyl cellulose: Experiments, characterization and advanced modelling. Author is Wang, Huifeng; Li, Zichao; Yahyaoui, Samia; Hanafy, Hassan; Seliem, Moaaz K.; Bonilla-Petriciolet, Adrian; Luiz Dotto, Guilherme; Sellaoui, Lotfi; Li, Qun.

An activated carbon with a high surface area and outstanding adsorption properties was prepared for dye removal from water. The new adsorbent was obtained from the chem. activation and pyrolysis of sodium CM-cellulose (CMC). This activated carbon was employed to analyze and characterize the adsorption mechanism of three dye mols.: methyl violet, allura red and congo red. Different characterization techniques and exptl. adsorption isotherms quantified at different temperatures (25-45°C) were utilized to interpret the dye adsorption mechanism. A double layer adsorption model was employed to estimate the steric and energetic parameters associated with the adsorption of these dye mols. The modeling results provided the possible adsorption orientations of these dyes on adsorbent surfaces at different operating temperatures and the number of bonded dye mols. per functional group of this adsorbent was also analyzed. Calculated adsorption energies showed that both exothermic and endothermic processes were feasible for these dyes and phys. forces were involved in the adsorption mechanism. Overall, this new adsorbent showed a competitive performance for dye removal in aqueous solution and can be a potential option for industrial applications.

There is still a lot of research devoted to this compound(SMILES：O=S(C1=CC=C2C(/N=N/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+])Recommanded Product: 25956-17-6, and with the development of science, more effects of this compound(25956-17-6) can be discovered.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics