Day: October 15, 2021

Moon, S; Horiuchi, S; Sakuda, E; Ito, A; Arikawa, Y; Umakoshi, K in [Moon, Sangjoon; Horiuchi, Shinnosuke; Sakuda, Eri; Arikawa, Yasuhiro; Umakoshi, Keisuke] Nagasaki Univ, Grad Sch Engn, Div Chem & Mat Sci, Bunkyo Machi, Nagasaki 8528521, Japan; [Ito, Akitaka] Kochi Univ Technol, Grad Sch Engn, 185 Miyanokuchi, Kochi 7821502, Japan published Synthesis and photophysical properties of butterfly-shaped dinuclear Pt(II) complex having NHC-based chelate ligands in 2019.0, Cited 48.0. Formula: C5H8N2. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

A butterfly-shaped dinuclear Pt(II) complex having pyridyl-NHC chelate ligands and bridging Me(2)pz ligands was synthesized. The crystal structure of the Pt-2 complex showed short intramolecular Pt center dot center dot center dot Pt distance (3.129 angstrom) and unique packing structure containing one-dimensional infinite pore that was filled with solvent molecules. The absorbance was proportional to the concentration of Pt-2 complex and no significant bands appeared even in high concentration (up to 100 mu M). The Pt-2 complex showed bluish-green emission (lambda(max) = 459 nm) in the solid state at 298 K (lambda(ex) = 330 nm). TD-DFT calculation revealed that the lowest-energy absorption bands are mainly assigned to the combination of metal-to-ligand charge transfer (MLCT) and ligand-to-ligand charge transfer (LLCT) transitions.

Formula: C5H8N2. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Moon, S; Horiuchi, S; Sakuda, E; Ito, A; Arikawa, Y; Umakoshi, K or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Electrochemical oxidative C-H/N-H cross-coupling for C-N bond formation with hydrogen evolution WOS:000457875500025 published article about METAL-FREE; FUNCTIONALIZATION; IMIDAZOHETEROCYCLES; DIFUNCTIONALIZATION; THIOCYANATION; SULFENYLATION; INHIBITORS; AMINATION; PYRIDINES; RADICALS in [Yu, Yi; Liu, Huilin; He, Min; Yang, Mingzhu; Liu, Pan; Yu, Banying; Dong, Xuanchi; Lei, Aiwen] Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China; [Yuan, Yong; Lei, Aiwen] Wuhan Univ, IAS, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China in 2019.0, Cited 59.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Safety of 3,5-Dimethyl-1H-pyrazole

Under metal catalyst-free and exogenous-oxidant-free conditions, a series of C-3 aminated imidazo[1,2-a]pyridines were synthesized by electrochemical intermolecular oxidative C-H/N-H cross-coupling. Furthermore, by using a catalytic amount of ferrocene as the mediator, electrochemical intramolecular oxidative C-H/N-H cross-coupling for the synthesis of 10H-benzo[4,5] imidazo[1,2-a]indole derivatives has also been accomplished.

Safety of 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Yu, Y; Yuan, Y; Liu, HL; He, M; Yang, MZ; Liu, P; Yu, BY; Dong, XC; Lei, AW or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In 2020 TETRAHEDRON published article about HENRY NITROALDOL REACTIONS; ORGANIC-SYNTHESIS; ON-WATER; DERIVATIVES; ANTIPYRINE; ALCOHOLS; HETEROCYCLES; CHEMISTRY; CYCLIZATION; EFFICIENT in [Zhang, Yong; Nie, Long-Jun; Luo, Lang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing] Garman Normal Univ, Key Lab Organopharmaceut Chem, Ganzhou 341000, Peoples R China in 2020, Cited 69. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0. Product Details of 86-92-0

The selective condensation of pyrazolones with isatins using water as the reaction medium is presented. This strategy provides an environmentally benign synthetic route to synthesize various potentially bioactive pyrazolone substituted oxindoles. (C) 2020 Elsevier Ltd. All rights reserved.

About 3-Methyl-1-p-tolyl-5-pyrazolone, If you have any questions, you can contact Zhang, Y; Nie, LJ; Luo, L; Mao, JX; Liu, JX; Xu, GH; Chen, DL; Luo, HQ or concate me.. Product Details of 86-92-0

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Authors Ishihara, K; Nishimura, K; Yamakawa, K in WILEY-V C H VERLAG GMBH published article about DIELS-ALDER; ENANTIOSELECTIVE FLUORINATION; CRYSTAL-STRUCTURE; CATION; PROPIOLOYLPYRAZOLES; CYCLOADDITION; ACYLPYRAZOLES; DESIGN; ROUTE; SET in [Ishihara, Kazuaki; Nishimura, Kazuki; Yamakawa, Katsuya] Nagoya Univ, Grad Sch Engn, Chikusa Ku, B2-3 611,Furo Cho, Nagoya, Aichi 4648603, Japan in 2020.0, Cited 49.0. Safety of 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Catalytic enantioselective alpha-fluorination reactions of carbonyl compounds are among the most powerful and efficient synthetic methods for constructing optically active alpha-fluorinated carbonyl compounds. Nevertheless, alpha-fluorination of alpha-nonbranched carboxylic acid derivatives is still a big challenge because of relatively high pK(a)values of their alpha-hydrogen atoms and difficulty of subsequent synthetic transformation without epimerization. Herein we show that chiral copper(II) complexes of 3-(2-naphthyl)-l-alanine-derived amides are highly effective catalysts for the enantio- and site-selective alpha-fluorination ofN-(alpha-arylacetyl) andN-(alpha-alkylacetyl) 3,5-dimethylpyrazoles. The substrate scope of the transformation is very broad (25 examples including a quaternary alpha-fluorinated alpha-amino acid derivative). alpha-Fluorinated products were converted into the corresponding esters, secondary amides, tertiary amides, ketones, and alcohols with almost no epimerization in high yield.

About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Ishihara, K; Nishimura, K; Yamakawa, K or concate me.. Safety of 3,5-Dimethyl-1H-pyrazole

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Recently I am researching about C-H; BIOLOGICAL EVALUATION; PHOTOREDOX CATALYSIS; IN-VITRO; ALPHA-GLUCOSIDASE; PYRAZOLE; DERIVATIVES; POTENT; INHIBITORS; DESIGN, Saw an article supported by the Kuwait University [SC13/18]; [GS01/01]; [GS01/05]; [GS01/03]; [GS03/08]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Ibrahim, HM; Behbehani, H. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone. Quality Control of 3-Methyl-1-p-tolyl-5-pyrazolone

A novel, metal catalyst-free, and efficient method has been developed for the synthesis of (pyrazol-4-ylidene) pyridine derivatives. The process involves dehydrogenative coupling of 1-amino-2-imino-pyridines with 1-aryl-5pyrazolone derivatives utilizing O-2 as the sole oxidant. The new method benefits from a high atom economy, efficiency, and substrate scope, as well as the simplicity of reaction and product purification procedures.

About 3-Methyl-1-p-tolyl-5-pyrazolone, If you have any questions, you can contact Ibrahim, HM; Behbehani, H or concate me.. Quality Control of 3-Methyl-1-p-tolyl-5-pyrazolone

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C12H12N2O3. In 2020 CANCER MANAG RES published article about CLINICAL-PRACTICE; SURVIVAL; MULTICENTER; ANTITUMOR; SAFETY; SITE; SEX in [Novakova-Jiresova, Alena; Boublikova, Ludmila; Buchler, Tomas] Charles Univ Prague, Fac Med 1, Dept Oncol, Videnska 800, Prague 14059, Czech Republic; [Novakova-Jiresova, Alena; Boublikova, Ludmila; Buchler, Tomas] Charles Univ Prague, Thomayer Hosp, Videnska 800, Prague 14059, Czech Republic; [Kopeckova, Katerina; Batko, Stanislav; Linke, Zdenek; Prausov, Jana] Charles Univ Prague, Univ Hosp Motol, Dept Oncol, Prague, Czech Republic; [Chloupkov, Renata] Masaryk Univ, Fac Med, Inst Biostat & Anal, Brno, Czech Republic; [Melichar, Bohuslav] Palacky Univ Med, Dept Oncol, Olomouc, Czech Republic; [Melichar, Bohuslav] Teaching Hosp, Olomouc, Czech Republic; [Petruzelka, Lubos] Charles Univ Prague, Gen Fac Hosp, Dept Oncol, Prague, Czech Republic; [Finek, Jindrich; Fiala, Ondrej] Charles Univ Prague, Med Sch, Dept Oncol & Radiotherapy, Plzen, Czech Republic; [Finek, Jindrich; Fiala, Ondrej] Charles Univ Prague, Univ Hosp Pilsen, Plzen, Czech Republic; [Fiala, Ondrej] Charles Univ Prague, Fac Med Pilsen, Biomed Ctr, Plzen, Czech Republic; [Grell, Peter; Kiss, Igor] Masaryk Mem Canc Inst, Dept Comprehens Canc Care, Brno, Czech Republic in 2020, Cited 30. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3.

Purpose: Regorafenib is an oral multikinase inhibitor approved for the therapy of previously treated metastatic colorectal carcinoma (mCRC). The aim of the present study was to analyze the outcomes of treatment with regorafenib in real-world clinical practice based on data from a national registry. Methods: The CORECT registry, the Czech non-interventional database of patients with mCRC treated with targeted agents, searched for patients with metastatic CRC treated with regorafenib. In total, 555 evaluable patients were identified. Results: The median age at diagnosis was 61.7 years. All patients had disease progression on or after previous systemic treatment. Most patients were treated with an initial dose of 160 mg daily (n = 463; 83.6%). The median duration of treatment was 2.7 months (range 0.023.4 months). By the data cut-off date, 472 patients (85%) had completed treatment with regorafenib and were evaluable for treatment response evaluation. Partial response was reported in 13 patients (2.8%) and disease stabilization in 130 patients (27.5%). Median progression-free survival (PFS) and overall survival (OS) were 3.5 months (95% confidence interval [CI] 3.2-3.7 months) and 9.3 months (95% CI 8.3-10.3 months), respectively. The 6-month OS rate was 67.7% (95% CI 63.4-72.1%). Multivariable analysis showed that female gender, longer interval from diagnosis of metastatic disease, MO stage at diagnosis, and Eastern Cooperative Oncology Group performance status (ECOG PS) 0 were associated with longer PFS, while higher body-mass index (BMI), longer interval from diagnosis of metastatic disease, and ECOG PS of 0 were associated with longer OS. Conclusion: OS of patients treated with regorafenib in the real-world clinical practice in this cohort exceeded that reported in randomized trials. Regorafenib is a safe and active treatment option for a subgroup of patients with mCRC who are progressing after other systemic therapies and maintain good performance status.

Formula: C12H12N2O3. About 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, If you have any questions, you can contact Novakova-Jiresova, A; Kopeckova, K; Boublikova, L; Chloupkov, R; Melichar, B; Petruzelka, L; Finek, J; Fiala, O; Grell, P; Batko, S; Linke, Z; Kiss, I; Prausov, J; Buchler, T or concate me.

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article Reductive dehalogenation and dehalogenative sulfonation of phenols and heteroaromatics with sodium sulfite in an aqueous medium published in 2019.0. Name: 3,5-Dimethyl-1H-pyrazole, Reprint Addresses Cankar, P (corresponding author), Palacky Univ, Dept Organ Chem, 17 Listopadu 1192-12, Olomouc 77146, Czech Republic.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole

Prototropic tautomerism was used as a tool for the reductive dehalogenation of (hetero) aryl bromides and iodides, or dehalogenative sulfonation of (hetero) aryl chlorides and fluorides, using sodium sulfite as the sole reagent in an aqueous medium. This protocol does not require a metal or phase transfer catalyst and avoids using organic solvent as the reaction medium. This method is especially suitable for substrates that readily tautomerize (such as 2-or 4-halogenated aminophenols and 4-halogenated resorcinols), for which dehalogenation or sulfonation proceeds under mild reaction conditions (<= 60 degrees C). As sodium sulfite is an inexpensive, safe, and environmentally less hazardous reagent, this method has at least three potential applications: (i) in the deprotection of halogens as protecting groups, using sodium sulfite as a reducing agent; (ii) in the sulfonation of aromatic halides under mild reaction conditions avoiding hazardous and corrosive reagents/ solvents; and (iii) in the transformation of toxic halogenated aromatics into less harmful compounds. Name: 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Tomanova, M; Jedinak, L; Cankar, P or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Ultrasound-promoted green approach for the synthesis of multisubstituted pyridines using stable and reusable SBA-15@ADMPT/H5PW10V2O40 nanocatalyst at room temperature WOS:000557564600001 published article about ACTIVE HETEROGENEOUS CATALYSTS; LEWIS-ACID CATALYST; MESOPOROUS MCM-41 2; ONE-POT SYNTHESIS; MULTICOMPONENT SYNTHESIS; GRAPHENE OXIDE; SIMPLE ROUTE; NANOPARTICLES; OXIDATION; IMMOBILIZATION in [Mollakarimi Dastjerdi, Neda; Ghanbari, Mohammad] Univ Kashan, Fac Chem, Dept Organ Chem, Kashan, Iran in 2020.0, Cited 58.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Recommanded Product: 67-51-6

A facile one-pot protocol for the synthesis of 2-amino-3-cyanopyridins using SBA-15@Triazine/H(5)PW(10)V(2)O(40)as an efficient catalyst under ultrasonic conditions has been developed. The nanohybrid catalyst was prepared by the chemical anchoring of Keggin heteropolyacid H(5)PW(10)V(2)O(40)onto the surface of SBA-15 mesoporous silica modified with 2-APTS -4,6-bis(3,5-dimethyl-1H-pyrazol- 1-yl)-1,3,5-triazine (ADMPT) linker. Then the nanohybrid was used as a green, efficient, eco-friendly, and highly recyclable catalyst for the one-pot and multi-component synthesis of 2-amino-3-cyanopyridin derivatives from the reaction of aldehydes, malononitrile, cyclic ketones and ammonium acetate under ultrasound waves with good to excellent yields (79-95%) and in a short span of time. This nanocatalyst was characterized by using FT-IR, XRD, SEM, TEM, BET, and EDX techniques.

About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Dastjerdi, NM; Ghanbari, M or concate me.. Recommanded Product: 67-51-6

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Pd(ii)-Catalyzed alkyne annulation through allylic isomerization: synthesis of spiro-cyclopentadiene pyrazolones published in 2021. COA of Formula: C11H12N2O, Reprint Addresses Gogoi, S (corresponding author), North East Inst Sci & Technol, CSIR, Chem Sci & Technol Div, Appl Organ Chem, Jorhat 785006, Assam, India.; Gogoi, S (corresponding author), AcSIR, Ghaziabad 201002, India.. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone

The Pd(ii)-catalyzed activation of Csp(2)-H bond and double alkyne annulation which proceeds via allylic isomerization is reported for the first time. This reaction of antipyrines with alkynes provides an efficient synthetic route for the biologically important spiro-cyclopentadiene pyrazolones. In the presence of Lawesson’s reagent, this Pd(ii)-catalyzed annulation reaction affords another spiro-cyclopentadiene pyrazolone which displays very good fluorescence properties.

COA of Formula: C11H12N2O. About 3-Methyl-1-p-tolyl-5-pyrazolone, If you have any questions, you can contact Changmai, S; Sultana, S; Sarma, B; Gogoi, S or concate me.

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Authors Lu, Y; Xu, WQ; Hu, KK; Jin, SW; Sun, L; Liu, B; Wang, DQ in PERGAMON-ELSEVIER SCIENCE LTD published article about METAL-ORGANIC FRAMEWORKS; COMPLEXES; ACID in [Lu, Yuan; Xu, Weiqiang; Hu, Kaikai; Jin, Shouwen; Sun, Lei; Liu, Bin] ZheJiang A&F Univ, Jiyang Coll, Zhuji 311800, Zhejiang, Peoples R China; [Lu, Yuan; Xu, Weiqiang; Hu, Kaikai; Jin, Shouwen; Sun, Lei; Liu, Bin] ZheJiang A&F Univ, Key Lab Chem Utilizat Forestry Biomass Zhejiang P, Zhuji 311300, Zhejiang, Peoples R China; [Wang, Daqi] Liaocheng Univ, Dept Chem Engn, Liaocheng 252059, Peoples R China in 2019.0, Cited 19.0. Computed Properties of C5H8N2. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

The present study pertains to the synthesis and characterizations of nine novel mixed-ligand complexes of [Zn(Hdmpz)(2)(L1)(2)] (1) (dmpz = 3,5-dimethylpyrazolate, Ll = 2-bromobenzoate), [Zn(Hdmpz)(2)(L2)(2)] (2) (L2 = 4-tert-butylbenzoate), Zn(Hdmpz)(2)(L3)(2) (3) (L3 = 2-thiophenoate), [Zn(Hdmpz)(2)(L4)(2)] (4) (L4 = 4-methylsalicylate), [Cd(Hdmpz)(2)(L5)(2)](2) (5) (L5 = 2,6-dihydroxy benzoate), [Cd (Hdmpz)(2)(L6)(2)](2).2H(2)O (6) (L6 = 3-(4-methoxy-phenylcarbamoyI)-acrylate), [Zn(Hdmpz)(2)(L7)](2) (7) (L7 = acetylenedicarboxylate), [Zn(Hdmpz)(2)(L8)] (8) (L8 = 1,2-phenylenediacetate), and [Cd(Hdmpz)(L9) (H2O)(2)].H2O (9) (L9 = 3-nitrophthalate). The resulting complexes were formulated via EA, IR, and SCXRD, and the TGA of all the complexes was also evaluated. The X-ray studies reveal that these complexes present mononuclear to dinuclear structures with tetrahedral geometry around each Zn2+, and octahedral/pentagonal bipyramidal geometry for Cd2+ The Hdmpzs in all compounds are coordinated only in monodentate fashion with its neutral N. The carboxylates at 1-4 and 3-9 function only as unidentate coordination units, the CO2- in 5 has the chelating bidentate coordination mode. Compound 6 contains both unidentate bridging and bidentate chelating COO-. The free carboxylate 0 at 2-4 and 7-8 accept the intramolecular N-H…O H-bonds, at 1 and 7 the uncoordinated O participate in the intermolecular N-H…O H-bonds. For 6 there is intermolecular N H-0 H-bond from the NHCO and H2O, and intramolecular N-H…O H-bonds from the NH at Hdmpz, the NHCO (acceptor), and one 0 at the bismonodentate coordinated COO-. One anion at 6 also gives the intramolecular N H-H-bonds from the NHCO(donor) and one O at the bismonodentate coordinated COO-. The intermolecular N-H…O H-bonds are from the phenol at both 4 and 5, and from the H2O at 9. The CH3 at Hdmpz in all compounds are participated in the noncovalent bonds except 3. The intricate intra-and intermolecular N-H…O and O-H…O H-bonds as well as C-H…N, C-H, O..O, Br…O, CH3…CH, CH2…C, CH3…C, C-H..O, CH2…O, CH3…O, C-H…S, C-H…CH3- rt, and pi…phi associations are elucidated by the X-ray crystallographic studies, which unite the discrete units into high-dimensional ordered supramolecular structures. (C) 2018 Elsevier Ltd. All rights reserved.

Computed Properties of C5H8N2. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Lu, Y; Xu, WQ; Hu, KK; Jin, SW; Sun, L; Liu, B; Wang, DQ or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics