Reference of 876343-24-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 876343-24-7, name is 1-Ethyl-1H-pyrazol-4-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Example 1; iV-(l-ethylpyrazol-4-yl)-2-[5-(6,7-dimethoxyquinolin-4-yIoxy)pyrimidin-2-yl]acetamide; l-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.123 g) was added to a stirred mixture of 2- [4-(6,7-dimethoxyquinolin-4-yloxy)pyrimidin-2-yl] acetic acid (0.11 g), 4-amino-l-ethyl-lH-pyrazole (0.09 g), diisopropylethylamine (0.225 ml), 2-hydroxypyridine iV-oxide (0.071 g) and DMF (2 ml) at ambient temperature. The resultant mixture was stirred and heated to 550C for 16 hours. The mixture was evaporated and the residue was partitioned between methylene chloride and water. The organic solution was dried over magnesium sulphate and evaporated. The residue was purified by column chromatography on silica using a solvent gradient of 10:0 to 9:1 mixtures of methylene chloride and methanol as eluent. There was thus obtained the title compound as a solid (0.1 g); 1H NMR: (DMSOd6) 1.33 (t, 3H), 3.94 (s, 3H), 3.96 (s, 3H), 3.99 (s, 2H), 4.07 (q, 2H), 6.65 (d, IH), 7.43 (m, IH), 7.52 (s, IH), 7.9 (s, IH), 8.54 (d, IH), 8.86 (s, 2H); Mass Spectrum: M+H+ 435.
The synthetic route of 1-Ethyl-1H-pyrazol-4-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/99335; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics