The important role of 150712-24-6

The synthetic route of 150712-24-6 has been constantly updated, and we look forward to future research findings.

Related Products of 150712-24-6,Some common heterocyclic compound, 150712-24-6, name is 5-Benzyl-1H-pyrazol-3-amine, molecular formula is C10H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 40 3-[(5-Benzyl-2H-pyrazol-3-ylamino)-methylene]-1,3-dihydro-indol-2-one The named compound is prepared by substituting 5-benzyl-2H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.231 gms. 5-benzyl-2H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (2.5 mL) overnight.

The synthetic route of 150712-24-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Allergan, Inc.; US6559173; (2003); B1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Sources of common compounds: 143426-49-7

The synthetic route of 143426-49-7 has been constantly updated, and we look forward to future research findings.

Reference of 143426-49-7,Some common heterocyclic compound, 143426-49-7, name is (4-Pyrazol-1-yl-phenyl)methanol, molecular formula is C10H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of (4-(1H-pyrazol-1-yl)phenyl)methanol (22.5 g) in acetonitrile (500 mL) was added N-fluoro-N’-(chloromethyl)triethylenediamine bis(tetrafluoroborate) (108 g) at room temperature, and the mixture was stirred at 80C for 16 hr. The reaction solution was diluted with ethyl acetate, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by silica gel chromatography (petroleum ether-ethyl acetate) to give the title compound (4.5 g). 1H NMR (400 MHz, CDCl3) delta 4.73 (2H, s), 7.45 (2H, d, J = 8.0 Hz), 7.57 (1H, d, J = 4.0 Hz), 7.61 (2H, d, J = 8.0 Hz), 7.80 (1H, d, J = 4.8 Hz).

The synthetic route of 143426-49-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; SUGIMOTO, Takahiro; NAKAMURA, Minoru; SAKAMOTO, Hiroki; SUZUKI, Shinkichi; YAMADA, Masami; KAMATA, Makoto; KOJIMA, Takuto; FUJIMORI, Ikuo; SHIMOKAWA, Kenichiro; EP2921480; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Share a compound : 1001020-17-2

According to the analysis of related databases, 1001020-17-2, the application of this compound in the production field has become more and more popular.

Synthetic Route of 1001020-17-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1001020-17-2 as follows.

A mixture of A-i (750 mg, 4.93 mmol), A-2 (0.46 mL, 7.39 mmol) and K2C03 (2.72 g, 19.71 mmol) in 10 mL DMF is heated at 85 C for 3 hours. The reaction mixture is diluted with EtOAc, washed with water, brine, dried over Na2SO4, concentrated in vacuo. The residue is purified by column chromatography on silica gel eluting with 10-100% EtOAc in heptane to yield Intermediates A and B as a 10:1 mixture by 1HNMR.

According to the analysis of related databases, 1001020-17-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HUGHES, Robert Owen; LI, Xiang; NEMOTO, Peter Allen; SMITH KEENAN, Lana Louise; WU, Lifen; XIONG, Zhaoming; (65 pag.)WO2018/111803; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The important role of C13H15N3O2

The synthetic route of 15001-11-3 has been constantly updated, and we look forward to future research findings.

15001-11-3, name is Ethyl 5-amino-1-(p-tolyl)-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 15001-11-3

General procedure: Intermediate 4 (0.001mol) and 5 (0.001mol) were dissolved in pyridine, phosphorus oxychloride is slowly added dropwise under ice bath conditions, then at 40-60C reacted for 5-8h. Finally, the mixture was poured into 30mL saturated Na2CO3 solution and stirred well. After the mixture was acidified, the saturated CuSO4 solution was used to remove pyridine, which greatly improved the purity and yield of the product. The data for compounds 8I-8VI are provided in the supporting information.

The synthetic route of 15001-11-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Hao; Ren, Zi-Li; Wang, Wei; Gong, Jie-Xiu; Chu, Ming-Jie; Ma, Quan-Wei; Wang, Jie-Chun; Lv, Xian-Hai; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 81 – 87;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

New learning discoveries about 1125828-30-9

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1125828-30-9.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1125828-30-9, name is 1-(4-Chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethanone, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-(4-Chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethanone

Step 3:A solution of dichloro (pentamethylcyclopentadienyl)iridium (III) dimer([Cp*IrCl2]2, CAS No. 12354-84-6, 3 mg), (1R,2R)-(-)-(4-toluenesulfonyl)-1,2-diphenylethylenediamine(CAS No. 144222-34-4, 2.5 mg), and water (12 mL) at room temperature. Theresulting mixture was heated to 40 oC for 3 h to give a homogeneousorange solution. To this active catalyst solution, and at the same temperature(40 oC), were added potassium formate anda solution of 1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethanone(5 g) in CH3CN. The reactionmixture was then stirred at 40 oC for 2 h. After cooling to 30 oC,the aqueous layer was removed. The organic layer was treated with activatedcharcoal (Darco G-60, 12g, CAS: 7440-44-0) at 45 oC for 2 h andfiltered through inch bed of Filter agent (CAS: 61790-53-2) and washed withCH3CN. The filtrate was concentrated to 150 mL. An additional amountof CH3CN (30 mL) was added to increase the solution volume to 180mL. This solution was warmed to 60 oC and water was added to thissolution at the same temperature. After stirring for 15 min at 60 oC,the resulting emulsion-like milky mixture was slowly cooled to room temperaturewith stirring. The crystals were then filtered at room temperature and washedwith CH3CN/water (1:2, 90 mL). The wet cake was dried under vacuumat 40 oC for 4 h to afford the title alcohol (44) as white solid (55g).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1125828-30-9.

Reference:
Article; Aiello, Robert; Barucci, Nicole; Bourassa, Patricia; Goldberg, Daniel R.; Paralkar, Vishwas; Valentine, James; Zavadoski, William; Zhang, Qing; De Lombaert, Stephane; Bioorganic and medicinal chemistry letters; vol. 26; 4; (2016); p. 1124 – 1129;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Some tips on 16082-33-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole-3,5-diamine, other downstream synthetic routes, hurry up and to see.

Application of 16082-33-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16082-33-0, name is 1H-Pyrazole-3,5-diamine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 36 N-{5-f2-(2,3-Difluoro-phenyl)-ethvn-7-hvdroxy-pyrazolori,5-a1pyrimidin-2-yl) acetamide; 1 0 g of 1 H-Pyrazole-3,5-diotaamiotane {Intermediate G) is dissolved in 15 ml of AcOH 3 0 g of 5- (2,3-diotafluoro-phenyl)-3-oxo-pentanoiotac acid ethyl ester (Intermediate A4) added and the solution is heated at 100 for 18 hours The reaction is then cooled to 0 and the solids collected by suction filtration and washed well with AcOH and diethyl ether and then dried under vacuum to yield the title compound 1H NMR (400 MHz, DMSO-d6) 12 10 (1 H1 br), 10 88 (1 H, s), 7 28 (1 H, m), 7 12 (2H, m), 6 41 (1 H, s), 5 52 (1 H, s), 3 05 (2H, t), 2 85 (2H, t) 2 02 (3H, s)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole-3,5-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; WO2009/106539; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 39846-84-9

The chemical industry reduces the impact on the environment during synthesis Ethyl 5-nitro-1H-pyrazole-3-carboxylate. I believe this compound will play a more active role in future production and life.

Application of 39846-84-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39846-84-9, name is Ethyl 5-nitro-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 5-Nitro-lH-pyrazole-3-carboxylic acid ethyl ester (0.925 g, 0.500 mmol) in absolute ethanol (10 cm3) was added 10% Pd/C (0.100 g). The mixture was stirred under an atmosphere of H2 at room temperature for 18 hours, filtered through Celite and the solvent removed under reduced pressure to give a green solid (0.70 g, 90%). 1H (CD3OD): 6.0 (s, IH), 4.3 (q, 2H, J=7.1, CO2CH2CH3), 1.4 (t, 3H, J=7.1,CO2CH2CH3). m/z (ES+): 156 [M+H]+

The chemical industry reduces the impact on the environment during synthesis Ethyl 5-nitro-1H-pyrazole-3-carboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2006/127595; (2006); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Share a compound : Methyl 3-formyl-1-methyl-1H-pyrazole-5-carboxylate

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-formyl-1-methyl-1H-pyrazole-5-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference of 1031351-95-7, The chemical industry reduces the impact on the environment during synthesis 1031351-95-7, name is Methyl 3-formyl-1-methyl-1H-pyrazole-5-carboxylate, I believe this compound will play a more active role in future production and life.

Preparation of hydroxylamine aqueous solution: Mix 3.13g hydroxylamine hydrochloride and 2.46g sodium acetate, Add 15mL water, The aqueous solution of hydroxylamine was prepared by stirring at room temperature. Dissolve 5.1 g (30 mmol) of 3-formyl-1-methyl-1H-pyrazole-5-carboxylic acid ethyl ester(I-1, R7=Me) (synthesized according to the reporting method of CN1278820) in 20 mL of THF, Add the prepared hydroxylamine aqueous solution dropwise at room temperature, and continue stirring for 2 hours after the drop . After complete reaction, THF was removed by desolvation, after adding water, filtering, washing with water and drying to obtain 4.95 g of white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-formyl-1-methyl-1H-pyrazole-5-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang Chemical Institute Co., Ltd.; Sinochem Lantian Group Co., Ltd.; Peng Weili; Xing Jiahua; Li Jiao; Xu Tianming; Huang Hongying; Yu Jiping; (32 pag.)CN111362931; (2020); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The important role of C6H11N3O

The synthetic route of 948570-74-9 has been constantly updated, and we look forward to future research findings.

Related Products of 948570-74-9,Some common heterocyclic compound, 948570-74-9, name is 1-(2-Methoxyethyl)-1H-pyrazol-4-amine, molecular formula is C6H11N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2; N- [l-(2-methoxyethyl)pyrazol-4-yl] -2- [4-(6,7-dimethoxyqumolin-4-yloxy)phenyl] acetamide; 0 Diisopropylethylamine (0.124 ml) and 2-(7-azabenzotriazol-l-yl)-1,1,3,3-tetramethyluronium hexafiuorophosphate(V) (0.247 g) were added in turn to a stirred mixture of 2-[4-(6,7-dimetlioxyquinolin-4-yloxy)phenyl]acetic acid (0.2 g), 4-amino- l-(2-methoxyethyl)pyrazole (0.092 g) and DMF (3 ml) and the resultant mixture was stirred at ambient temperature for 18 hours. The resultant mixture was evaporated and the residue was purified by column chromatography on silica using a solvent gradient from 100:0 to 24:15 mixtures of methylene chloride and a 3.5M methanolic ammonia solution as eluent. There was thus obtained the title compound as a solid (0.106 g); 1H NMR: (DMSOd6) 3.21 (s, 3H), 3.62 (s, 2H), 3.63 (t, 2H), 3.92 (s, 3H), 3.94 (s, 3H), 4.12 (t, 2H), 6.47 (d, IH), 7.22 (d, 2H), 7.4 (s. IH), 7.44 (s, IH), 7.45 (d, 2H), 7.49 (s, IH), 7.89 (s, IH), 8.47 (d, IH), 10.2 (s, IH); Mass Spectrum: M+H+ 463.

The synthetic route of 948570-74-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/99326; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Extended knowledge of 39846-84-9

According to the analysis of related databases, 39846-84-9, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39846-84-9, name is Ethyl 5-nitro-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H7N3O4

(Step 3) Production of ethyl 5-amino-3-pyrazolecarboxylate To a solution of ethyl 5-nitro-3-pyrazolecarboxylate (331.48 g) in tetrahydrofuran (1.5 L) and ethyl acetate (1.5 L) was added 7.5% palladium carbon (30.036 g), and the mixture was stirred overnight at room temperature under a hydrogen atmosphere. The catalyst was filtered off, the filtrate was concentrated, and the resulting solid was recrystallized with ethyl acetate/hexane to obtain the title compound (265.38 g) as white crystals.

According to the analysis of related databases, 39846-84-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JAPAN TOBACCO, INC.; US2009/36450; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics