Day: May 7, 2021

Electric Literature of 151521-49-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 151521-49-2, name is 4-Isopropyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows.

Na (859 mg, 37.4 mmol) was added into anhydrous EtOH (100 mL) at l0C, the resulting mixture was stirred for 1 hour at 10C under N2 atmosphere, then compound C3 (3.90 g, 31.1 mmol) and diethyl propanedioate (5.99 g, 37.4 mmol) was added to the mixture. The mixture was heated at 80C and stirred for another 15 hours under N2 atmosphere to give yellow solution. TLC showed the reaction was completed. The reaction mixture was cooled to room temperature and concentrated to obtain residue. The residue was dissolved in water (60 mL) and acidified to pH= 3 with 3M HC1, filtered to give compound El (3.60 g) as an off-white solid.

The chemical industry reduces the impact on the environment during synthesis 4-Isopropyl-1H-pyrazol-5-amine. I believe this compound will play a more active role in future production and life.

Application of 39806-90-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A suspension of 5-chloro-lH-pyrazolo[3,4-c]pyridine (300 mg, 1.95 mmol), 4- iodo-l-methylpyrazole (600 mg, 2.88 mmol), 2-isobutyrylcyclohexanone (130 mg, 0.773 mmol), copper(I) iodide (75 mg, 0.39 mmol) and cesium carbonate (1.5 g, 4.60 mmol) in 5 mL of DMA was deoxygenated by bubbling nitrogen for 15 min. Next, the reaction mixture was warmed to (0809) 100C and stirred overnight. The reaction mixture was then cooled and diluted with DCM, washed with 1 N aqueous NaOH and water, dried (Na2S04) and concentrated to dryness. The solid residue was suspended in ether and filtered to collect the desired intermediate, 5-chloro-l- (0810) (l-methyl-lH-pyrazol-4-yl)-lH-pyrazolo[3,4-c]pyridine: MS (EI) calc’d for Ci0H9ClN5 [M+H]+ (0811) 234, found 234; 1H NMR (600 MHz, OMSO-d6) delta 9.02 (s, 1 H), 8.41 (s, 1 H), 8.38 (s, 1 H), 7.97 (0812) (s, 1 H), 7.96 (s, 1 H), 3.91 (s, 3 H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 30169-25-6, name is 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine, A new synthetic method of this compound is introduced below., name: 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine

Compound 1 (270 mg, 1.0 mmol) was placed in a 50 ml round bottomed flask. acetonitrile (10 ml) was added. 1,4 phenylene diamine (108 mg, 1.0 mmol) was added and the reaction heated to reflux for 1 hour. The reaction was allowed to cool to ambient temperature and the precipitate was isolated by filtration. The product was washed with cold acetonitrile, and air dried to give 225 mg of a purple solid (80% yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 35691-93-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35691-93-1 name is Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 4.3.1. Ethyl 5-amino-2-methylpyrazolo[1,5-a]quinoline-3-carboxylate (7a). Condition C: A mixture of 2-fluorobenzonitrile6a (121 mg, 1.00 mmol), 1H-pyrazole 4 (202 mg, 1.20 mmol) andCs2CO3 (980 mg, 3.00 mmol) in DMF (5.0 mL) was stirred at 120 Cfor 16 h. After monitoring the end of the reaction on TLC, themixture was cooled to room temperature and diluted with water.The resulting mixture was extracted with ethyl acetate twice. Thecombined organic layers werewashed with water twice, dried overMgSO4 and the solvent was removed in vacuo to afford a residue.The residue was purified by flash column chromatography(hexane:EtOAc1:1) on silica gel to afford 7a (124 mg, 46% yield).Condition D: The reaction was carried out in DMSO instead of DMFunder the same conditions as that of condition C to afford 7a (175 mg, 65% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, and friends who are interested can also refer to it.

Synthetic Route of 31037-02-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The two Schiff base ligands were prepared based on the literature [44,45]. As shown in Scheme 1,a mixture of 5-amino-1-(2-hydroxyethyl)(2 mmol, 254 mg), 2-hydroxy-1-naphthaldehyde(2 mmol, 350 mg) glacial acetic acid in the ethanol solution (30 mL) was vigorouslystirred and refluxed at 80 C for 4 h.

The chemical industry reduces the impact on the environment during synthesis Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate. I believe this compound will play a more active role in future production and life.

Application of 5334-41-8, A common heterocyclic compound, 5334-41-8, name is 5-Amino-1-methyl-1H-pyrazole-4-carbonitrile, molecular formula is C5H6N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 20 2-(Azetidin-1-yl)-4-difluoromethoxybenzooxazole-7-carboxylic acid (4-cyano-2-methyl-2H-pyrazol-3-yl)-amide Starting from 2-(azetidin-1-yl)-4-difluoromethoxybenzooxazole-7-carboxylic acid 4-nitro-phenyl ester (178 mg) and 5-amino-1-methyl-1H-pyrazole-4-carbonitrile (107 mg). Purification by column chromatography on silica eluding with 3% methanol in dichloromethane followed by trituration in diethyl ether afforded the title compound as a white solid (124 mg). TLC Rf 0.31 (ethyl acetate). M.p. 247-248 C.

The synthetic route of 5334-41-8 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1260243-04-6, SDS of cas: 1260243-04-6

To a mixture of ethyl 3-amino-1H-pyrazole-4-carboxylate (29) (30.0 g, 193 mmol) and ethyl 3-ethoxy-2-propenoate (cis- and trans-mixture, 41.9 mL, 290 mmol) in DMF(387 mL) was added cesium carbonate (113 g, 348 mmol). Themixture was stirred at 100C for 2 h, diluted with water andthen acidified to pH ca. 5 with AcOH. The resulting solid wasfiltered by filtration, washed with water and dried to afford 30(36.4 g, 176 mmol, 91%) as a beige solid. 1H-NMR (300 MHz,DMSO-d6) delta: 1.28 (3H, t, J=7.1 Hz), 4.28 (2H, q, J=7.1 Hz),6.15 (1H, d, J=7.9 Hz), 8.13 (1H, s), 8.57 (1H, d, J=7.9 Hz),11.73 (1H, br s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5952-92-1, name is 1-Methyl-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-Methyl-1H-pyrazole-4-carboxylic acid

EXAMPLE 2 N-(2-Thienylsulfonyl)-1-methylpyrazole-4-carboxamide 3.8 g of 1-methylpyrazole-4-carboxylic acid and 4.9 g of carbonyldiimidazole in 100 ml of 1,2-dichloroethane are heated at 55° C. for 3.5 h. 4.9 g of 2-thienylsulfonamide and 5.4 ml of triethylamine are added and then the mixture is heated at 55° C. for 13 h. After cooling, 40 ml of 10percent strength aqueous NaOH solution are added and then the pH of the aqueous phase is adjusted to 1. The precipitate is removed and dried under reduced pressure. 5.2 g of N-(2-thienylsulfonyl)-1-methylpyrazole-4-carboxamide with a melting point of 174°-180° C. are obtained (active ingredient Example No. 103).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5952-92-1.

Reference of 39806-90-1, A common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 4-Iodo-1-methyl-1H-pyrazole 1 (101 mg, 0.5 mmol) and phenylboronic 2 (59 mg, 0.5 mmol) were dissolved in DME (3 mL) and H2O (1.2 mL) in a microwave vial under a nitrogen atmosphere. Pd(PPh3)4 (2 mmol%, 11.6 mg) and Cs2CO3 (407.3 mg, 1.25 mmol) were added, and the reaction mixture was irradiated in a microwave apparatus at 90 C for 5-12 min. After the reaction mixture was cooled to ambient temperature, the product was concentrated, and the crude mixture was purified by silica gel column chromatography using petroleum ether/acetone as eluent to give the title compound.

The synthetic route of 39806-90-1 has been constantly updated, and we look forward to future research findings.

Related Products of 20055-01-0, These common heterocyclic compound, 20055-01-0, name is 1-Methyl-1H-pyrazole-4,5-diamine sulfate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of 1, 1′-CARBONYLDIIMIDAZOLE (973 mg) in methylene chloride (10 ml) was added 0- [2- (tert- butoxycarbonylamino) ethyl] hydroxylamine (1.11 g) under ice-cooling, and the mixture was stirred at room temperature for 2 hours. To the reaction mixture were added N-ethyldiisopropylamine (1.28 g) and 4,5-diamino- 1-methylpyrazole sulfuric acid salt (1.05 g), and the mixture was stirred under reflux for 4 hours. The reaction mixture was washed with brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with 10% methanol/chloroform to give 5-amino-4- (3- {2- [ (TERT-BUTOXYCARBONYL) amino] ethoxy} UREIDO)-1- methylpyrazole (255 mg) as a solid. H-NMR (DMSO-d6) 8 1.38 (9H, s), 3.19-3. 20 (2H, m), 3.51 (3H, s), 3.72 (2H, t, J=6Hz), 4.86 (2H, br), 6.95 (1H, br), 7.06 (1H, s), 8.02 (1H, brs), 9.15 (1H, brs)

The synthetic route of 20055-01-0 has been constantly updated, and we look forward to future research findings.