Day: April 25, 2021

Reference of 2075-45-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2075-45-8 name is 4-Bromo-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Bromo-1-(1-ethoxyethyl)-1H-pyrazole (11-II-a)To a solution of 4-bromo-1H-pyrazole (3 g, 20.4 mmol), ethyl vinyl ether (1.76 g, 24.5 mmol) in DCM (30 mL) was added HCl (4M in dioxane, 0.16 mL), and the reaction mixture was stirred for 3 h at RT. After completion of the reaction (monitored by TLC), the reaction was neutralized with saturated NaHCO3 solution and extracted with DCM (3×100 mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo to afford 11-II-a (4.46 g, 89%) as colorless liquid; TLC: 30% EtOAc/Hexane (Rf: 0.7); 1H-NMR (CDCl3, 200 MHz): delta 7.60 (s, 1H), 7.46 (s, 1H), 5.46 (q, J=6.0 Hz, 1H), 3.55-3.25 (m, 2H), 1.63 (d, J=6.0 Hz, 3H), 1.15 (t, J=7.2 Hz, 3H); Mass: 221 [M++2].

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1H-pyrazole, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, A new synthetic method of this compound is introduced below., Product Details of 3524-32-1

(a) A mixture of 2-iodobenzoic acid (14.9 g, 0.06 mol), 5-amino-1,3-dimethylpyrazole (6.7 g, 0.06 mol), DMF (125 ml), Cu(OAc)2 (0,4 g) and K2CO3 (8.28 g, 0.06 mol) is refluxed overnight. The reaction mixture is poured into ice water (500 ml) and then is acidified with acetic acid to a pH of about 5. The solid that forms is collected by filtration, washed with water (100 ml) and dried. The solid is dissolved in hot CHCl3 (300 ml), filtered, dried over MgSO4 and evaporated to about 20 ml. Hexane (50 ml) is added, and then the product is collected by filtration, washed with hexane (30 ml) and dried to afford 6.2 g of N-(1,3-dimethyl-pyrazol-5-yl)anthranilic acid, m.p. 210-211 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1280210-79-8, name: tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate

To a suspension ofNaH (0.30 g, 7.5 mmol) in dry THF (5 mL) under nitrogen atmosphere at 0 C was added a solution of 4 (0.78 g, 3.7 mmol) in dry THF (30 mL). Thereaction mixture was allowed to come to room temperature and continued the stirring for 2hours. Reaction mixture was again cooled to 0 C. A solution of3 (2.0 g, 7.4 mmol) in THF (25mL) was added to the reaction mixture and continued the stirring for another 1 hour. Thereaction mixture was quenched with water (100 mL) and extracted with EtOAc (3 x 200 mL). Combined organics were dried over Na2S04, filtered, concentrated under vacuum and purifiedby silica gel chromatography afforded 5 as an off-white solid.251H NMR (400 MHz, CDCh): o 7.84- 7.88 (m, 1H), 7.78 (t, J = 8.27 Hz, 2H), 7.23- 7.30 (m,2H), 4.39 – 4.49 (m, 4H), 3.53 ( d, J = 2.40 Hz, 3H), 2.42 (s, 3H), 1.53 (s, 9H).; MolecularFormula: C1sHz4N40sSz; LCMS purity: 98.18%; Expected: 440.1; Observed: 341.0 (M-99).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H7N3O2

To a suspension of 3,5-dimethyl-4-nitro-1H-pyrazole (201 mg, 1.4 mmol) and K2CO3 (216 mg, 1.6 mmol) indry DMF (1 mL), iodomethane (93 mL, 1.5 mmol) was added at room temperature. After 5 h, the reaction was heated to 40 C and additional iodomethane (90 mL) and K2CO3 (200 mg) was added. After 1.5 h, the reaction was quenchedwith Et3N (150 mL), diluted with H2O (15 mL) and EtOAc (15 mL). The two layers were separated and the aqueous layerwas extracted with EtOAc (2 x 10 mL). The combined organics were dried (MgSO4), filtered, and concentrated in vacuo.Purification by column chromatography (30% EtOAc in PE) yielded 206 mg (93%) of the title compound

The synthetic route of 3,5-Dimethyl-4-nitro-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Synthetic Route of 1572-10-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1572-10-7, name is 3-Amino-5-phenylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: An oven dried 25 mL RB flaskwas charged with chalcone (1.0 mmol), 3-aminopyrazole (1.2 mmol), KOH (0.1mmol) and DMF (5 mL). The resulting solution was stirred at 110 C for 20 min.On completion, the reaction mass was allowed to cool to ambient temperature,diluted with water (20 mL) and extracted into ethyl acetate (2 20 mL). The combined organic layers were dried overanhydrous Na2SO4, and organic solvent was evaporated on arotatory evaporator. The crude residue was purified by column chromatography(silica gel 60-120 mesh, eluent 20% EtOAc/hexanes).

The synthetic route of 3-Amino-5-phenylpyrazole has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51516-67-7, name is 5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C10H7ClN4

General procedure: Equimolar portionsof the intermediate compounds 1 (1 mmol) and the intermediatecompounds 3 (1 mmol) were dissolved in approximately 8 mL ofethanol. The reaction solution was allowed to stir at 80 8C for 2 huntil the reaction was complete. The reaction was monitored byTLC. Mostly, a precipitate formed and was then collected by suctionfiltration.

The synthetic route of 51516-67-7 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 92-43-3, name is 1-Phenyl-3-pyrazolidinone, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 92-43-3, Quality Control of 1-Phenyl-3-pyrazolidinone

EXAMPLE 2 alpha-Hydroxy-5-oxo-2-phenyl-1-pyrazolidine acetic acid By following the procedure of Example 1 and substituting 1-phenyl-3-pyrazolidinone for 1-[4-(trifluoromethyl)phenyl]-3-pyrazolinone the title compound is obtained in 48% yield, with a melting point of 127-9 C. Analysis for: C11 H12 N2 O4. Calcuated: C, 55.92; H, 5.12; N, 11.86. Found: C, 56.22; H, 5.37; N, 11.76.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 37687-24-4

A mixture of diethyl 1H-pyrazole-3,5-dicarboxylate (5.20 g, 24.5 mmol), 2-chloro-1-(3-chloro-4-methylphenyl)ethan-1-one (4.98 g, 24.5 mmol), potassium carbonate (3.73 g, 27.0 mmol) and water (3 drops) in acetone (100 ml) was stirred at RT overnight. The solids were then filtered off, and the filtrate was concentrated under reduced pressure. The residue was partitioned between dichloromethane and water. The layers were separated, and the organic layer was washed with water and brine, dried over sodium sulfate and filtered. The filtrate was concentrated under re- duced pressure to afford the crude title compound which was directly used in the next step with- out further purification. Yield: 7.99 g (83% of theory, 97% purity). LC/MS [Method 34]: Rt = 1.39 min; MS (ESIpos): m/z = 379/381 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 175137-46-9,Some common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a cold solution of 4,6-dichloropyrimidine-5-carbonitrile (500 mg, 2.87 mmol) in THF (10 mL) was added N,N-diisopropylethylamine (1.00 ml g, 5.75 mmol), followed by a solution of 3-cylopropyl-1-H-pyrazole amine (354 mg, 2.87 mmol) at 0 C. The resulting mixture was stirred at 0 C. for 2 hours. TLC was checked and the reaction was completed. After cooled to room temperature, half-saturated ammonium chloride in water (80 mL) was added and the mixture was stirred at room temperature for 15 min. The resulting solids were collected by filtration, washed by water to afford product compound 2 as yellow solids. (644 mg, 86% yield). 1H NMR (400 MHz, DMSO-d6) delta 12.42 (br, 1H), 10.35 (br, 1H), 8.55 (s, 1H), 6.12 (s, 1H), 1.89 (m, 1H), 0.92 (m, 2H), 0.67 (m, 2H); ESI-MS: calcd for (C11H9ClN6) 260, found 261 (MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Cyclopropyl-1H-pyrazol-3-amine, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 181585-93-3 as follows. name: Methyl 5-nitro-1H-pyrazole-3-carboxylate

[0567] To a solution of 5-nitro-2H-pyrazole-3-carboxylic acid methyl ester (200 mg, 1.17 mmol) in dry THF (10 mL) was added LiBH4 (2.34 mL, 2 M in THF) at 0 C, and the resulting mixture was allowed to warm to room temperature and stirred overnight. The reaction was monitored by TLC. Then the reaction was quenched with H20 (10 mL), and the mixture was extracted with EtOAc (20 mL x3). The combined organic layers were concentrated in vacuum to afford (5-nitro-lH-pyrazol-3-yl)-methanol (154 mg, yield: 92%) as a white solid. [0568] 1H MR (400 MHz, DMSO-6): delta = 13.89 (brs, 1H), 6.86 (d, J = 1.6 Hz, 1H), 5.57 (brs, 1H), 4.53 (s, 2H).

According to the analysis of related databases, 181585-93-3, the application of this compound in the production field has become more and more popular.