Day: April 14, 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27006-76-4, name is 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxaldehyde

General procedure: To a solution of substituted phenol (75 mmol) in N,N-dimethylformamide (60 mL) was addedpotassium hydroxide (100 mmol) at room temperature. The reaction mixture was heated to 40 C for 6 h. Then to the above mixture was added compound 6 (50 mmol) in portions, and the resultingmixture was heated to 100 C for 12-20 h. The reaction solution was poured into water (100 mL) andwas continuously extracted with ethyl acetate (3 50 mL). The combined organic layer was washedby water and brine, dried over anhydrous Na2SO4, and concentrated in rotatory evaporator to givecompounds 7a-7w, with yields ranging from 58% to 80% [26].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 27006-76-4.

Related Products of 2458-26-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2458-26-6, name is 3-Phenyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 3,5-dimethyl-1-(3-phenoxypropyl)-1H-pyrazole (L1): A solution of 3,5-dimethyl-1H-pyrazole (0.30 g, 3.2 mmol) in DMF/THF (v/v = 1:1, 12 mL) was added to a suspension of NaH (0.15 g, 6.4 mmol) in DMF/THF (v/v = 2:1, 15 mL) and stirred at 60 C for 2 h. Then, the resulting solution was added under stirring to a solution of 3-bromopropyl phenyl ether (0.70 g, 3.2 mmol) in DMF (7 mL). The mixture was allowed to stir for 24 h at 60 C, cooled, and treated cautiously with H2O (5 mL) to decompose excess NaH. The solvents were then evaporated under reduced pressure. The residue was extracted with ethyl acetate (3 * 15 mL), washed with H2O (2 * 15 mL). The organic phase was dried over MgSO4 and filtered, before the solvent was evaporated under reduced pressure. After workup and purification by chromatographic column on silica gel (hexane/ethyl acetate, 90:10), L1 was obtained as a colorless oil (0.47 g, 64%).

The chemical industry reduces the impact on the environment during synthesis 3-Phenyl-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Application of 1280210-79-8, The chemical industry reduces the impact on the environment during synthesis 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, I believe this compound will play a more active role in future production and life.

INTERMEDIATE 6; 2-(2-Hydroxy-2-methylpropyl -2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-5-ium trifluoroacetate saltTo a stirred solution of tert-butyl 2,6-dihydropyrrolo[3 ,4-c]pyrazole-5(4H)-carboxyIate(35 g, 167 mmol) in DMF (500 mL) at 0 C under N2 was added sodium hexamethyldisilazide in THF (351 mL, 351 mmol) and the mixture was stirred at 0 C for 30 min. Isobutylene oxide (74.3 mL, 836 mmol) was then slowly added. The solution was stirred at 0C for 0.5 h and then stirred at room temperature for 1 h. The solution was heated to 80C for 100 min in a microwave oven, cooled to room temperature and evapoarted under vacuum. The residue was purified by column chromatography on silica gel, eluting with a gradient of 0% to 6% CH2Cl2 MeOH (containing 1 % NH4OH) to give a mixture of two regioisomers. The mixture of tworegioisomers A and B was resolved by chromatography on a ChiralPak AD-H column eluting with 4-40% MeOH/C02 to give isomer A as the faster eluting isomer and isomer B as the slower eluting isomer. NMR (500 MHz, CD3OD) for isomer B: 67.42 (d, 1 H); 4.42 (s, 2H); 4. 1 (s, 2H); 4.07 (s, 2H); 1.51 (d, 9H); 1.16 (s, 6H). LC-MS: 226.27 (M+l-56).The desired isomer B was treated with 1 :1 TFA/C?C12 for 1 h to give the title compound. NMR (500 MHz, CD3OD): 57.55 (s, 1H); 4.43 (s, 2H); 4.39 (s, 2H); 4.10 (s, 2H);1.17 (s, 6H). LC-MS: 182.31 (M+l).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 42098-25-9, name is 5-Chloro-1-methyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 42098-25-9, category: pyrazoles-derivatives

Intermediate 43 1-tert-butyl 3-methyl 2-(1-methyl-4-nitro-1H-pyrazol-5-yl)malonate Potassium carbonate (15.40 g, 111.42 mmol) was added in one portion to a stirred, RT solution of 5-chloro-1-methyl-4-nitro-pyrazole (6.0 g, 37.140 mmol) and tert-butyl methyl melonate (8.74 g, 50.139 mmol) in anhydrous DMSO (100 mL) under nitrogen. The mixture was heated at 75 C. for 3 hours before being cooled and allowed to stand at RT overnight. The mixture was poured into water (500 mL), acidified with 2N HCl (80 ml, PH 5) and extracted with EtOAc (2*250 mL, 2*200 ml). The combined organics were dried (MgSO4) and the solvent removed under reduced pressure. The residue was purified via silica gel chromatography (0-30% EtOAc/heptane) to afford 1-tert-butyl 3-methyl 2-(1-methyl-4-nitro-1H-pyrazol-5-yl)malonate as a colorless solid (10.3 g, 92.7%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-1-methyl-4-nitro-1H-pyrazole, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42027-81-6, name is 2-(4-Nitro-1H-pyrazol-1-yl)ethanol, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

A solution of 4-nitro-lH-pyrazole (l .Og, 8.85mmol), potassium carbonate (2eq) and 2- bromoethanol (l . leq) in acetonitrile (30mL) was heated at 60C for 18h. After cooling to rt the mixture was diluted with EtOAc and washed with H20. The organic phase was collected, dried (hydrophobic frit) and concentrated in vacuo. The crude residue was dissolved in ethanol (30mL), palladium on carbon (50mg) was added and the reaction was stirred under a balloon of hydrogen for 18h. The resulting mixture was filtered through Celite and the filtrate concentrated in vacuo to give 2-(4-amino-lH-pyrazol-l-yl)ethanol

According to the analysis of related databases, 42027-81-6, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 35100-92-6, name is 1,5-Dimethyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35100-92-6, category: pyrazoles-derivatives

73 Preparartion of N.N-dicvclopropyl-6-ethyl-l-methyl-4-(l ,5-dimethyl-lH- pyrazol-3-ylamino)-1.6-dihydroimidazo[4.5-dlpyrrolo[2.3-blpyridine-7-carboxamide[00362] To a vial containing 1,5 -dimethyl- lH-pyrazol-3 -amine (13.60 mg, 0.122 mmol), Pd2(dba)3 (4.67 mg, 5.10 muiotaetaomicron), Xantphos (5.90 mg, 10.20 muiotaetaomicron), and cesium carbonate (100 mg, 0.306 mmol) was added N,N-dicyclopropyl-6-ethyl-4-iodo- 1- methyl-l,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide (45.8 mg, 0.102 mmol) in DME (1020 muKappa). The reaction mixture was sparged with argon for 5 min, the vial was capped, and the reaction mixture was heated at 90 C 1 h. The reaction mixture was diluted with dichloromethane and vacuum filtered through Celite. The filtrate was concentrated in vacuo. The crude residue was purified via flash column chromatography using an ISCO 12 g column eluting with 1 – 10%MeOH/CH2Cl2). N,N-Dicyclopropyl-4-(l,5-dimethyl-lH-pyrazol-3-ylamino)-6- ethyl- l-methyl-l,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide (14 mg, 31.7 % yield) was isolated as an off-white solid.[00363] MS (ESI) m/z 433.2 (M+H).[00364] XH NMR (500 MHz, CDC13) delta: 8.19 (s, 1H), 7.63 (s, 1H), 6.94 (s, 1H), 6.85 (s, 1H), 4.65 (q, J = 7.0 Hz, 2H), 3.99 (s, 3H), 3.71 (s, 3H), 2.79 – 2.85 (m, 2H), 2.33 (s, 3H), 1.49 (t, J = 7.2 Hz, 3H), 0.82 – 0.87 (m, 4H), 0.72 – 0.78 (m, 4H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Electric Literature of 13808-62-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13808-62-3, name is 4-Methyl-3-phenyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Alternate Synthesis for alpha-ethyl-N,N,4-trimethyl-3-phenylpyrazole-1-acetamide Sodium methoxide powder (216 g., 4.0 mole) was added over 10 minutes at a stirred solution of 4-methyl-3-phenylpyrazole (632 g., 4.0 mole) in tetrahydrofuran (1.0 liter) at 10 C. 2-Bromo-N,N-dimethylbutyramide (911 g., 4.7 mole) was added dropwise over 30 minutes while maintaining the temperature of the reaction solution below 30 C. by external cooling. The solution was stirred for an additional 30 minutes at room temperature, and the THF was then removed under reduced pressure. The residual oil was partitioned between chloroform and water. The chloroform layer was evaporated and the residual oil was recrystallized from benzene:Skellysolve B to give 772 g. of alpha-ethyl-N,N,4-trimethyl-3-phenylpyrazole-1-acetamide, m.p. 85.5-87.5 C. Evaporation of the crystallization mother liquors gave 365 g. of oil containing additional product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methyl-3-phenyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 39806-90-1, A common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 1-Methyl-4-(methylthio)-1H-pyrazole To a solution of 4-iodo-1-methyl-1H-pyrazole (0.5 mL, 5.2 mmol) in THF (2 mL) at -78 C. under an atmosphere of N2 was added isopropylmagnesium chloride (5.2 mL, 10.4 mmol) and the resulting mixture was stirred for 30 minutes. To the reaction mixture was added dimethyl disulfide (1 mL, 11 mmol). The reaction was poured into aq. sat. NH4Cl (25 mL), the layers were separated and the aqueous layer was extracted with Et2O (100 mL). The combined organic layers were dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by reverse phase preparative HPLC (Mobile Phase: A=10 mM NH4HCO3 in H2O, B=MeCN; Gradient: B=95%; 13 min; 30 mL/min; column: Xtimate Prep C18 OBD 21.2*250 mm, 10 mum) to afford the title compound (740 mg, 29%) as an off-white solid. (ES+) C5H8N2S requires: 128, found: 129 [M+H]+.

The synthetic route of 39806-90-1 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, molecular formula is C11H5Cl2F3N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile

General procedure: Phenylpyrazole (0.2 mmol), arylboronic acid (0.4 mmol), NIS (0.2 mmol), [Pd] (10 mol%), NaHCO3 (0.4 mmol) and C2H5OH:H2O (3:1, 10 mL), were added to a Schlenk tube. Then the tube was charged with N2 and the reaction mixture was stirred at 80 C for 18 h. After the completion of the reaction, as monitored by TLC, the mixture was cooled and filtrated. The filtrate was extracted with ethyl acetate and washed with brine. Then the combined organic extracts were dried over Na2SO4, concentrated under vacuum and the resulting residue was purified by silica gel column chromatography to afford the desired products.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 120068-79-3, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82560-12-1, COA of Formula: C7H13N3

3-Tert-butyl-1 H-pyrazol-5-amine (J-lll) (1 equivalents, 40 g) was dissolved in diluted HCI (120 mL of HCI in 120 mL of water) and mixed dropwise with NaN02 (1 .03 equivalents, 25 g in 100 mL) at 0 – 5 C over a period of 30 min. After stirring for 30 minutes, the reaction mixture was neutralised with Na2C03. A diazonium salt obtained by reaction of KCN (2.4 equivalents, 48 g), water (120 mL) and CuCN (1 .12 equivalents, 31 g) was added dropwise to the reaction mixture within 30 min and the mixture was stirred for a further 30 min at 75 C. After complete reaction, the reaction mixture was extracted with ethyl acetate (3 x 500 mL), the combined organic phases were dried over sodium sulphate and the solvent was removed under vacuum. The purification (silica gel: 100-200 mesh, eluent: 20 % ethyl acetate/n-hexane) of the residue by column chromatography produced a white solid (J-IV) (6.5 g, 15 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-5-tert-butylpyrazole, other downstream synthetic routes, hurry up and to see.