Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 119083-00-0, name is 1-Methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., Computed Properties of C6H5F3N2O2
Example 35 N-(l-(6-(4-Fluorophenyl)-4,5-dimethylpyridazin-3-yl)piperidin-4-yl)-N,l-dimethyl-5- (trifluoromethyl)- lH-pyrazole-4-carboxamide dihydrochloride; Dissolve l-(6-(4-fluorophenyl)-4,5-dimethylpyridazin-3-yl)-N-methylpiperidin-4- amine (800 mg, 4.12 mmol) in DMF (25 mL). Add l-methyl-5-(trifluoromethyl)-lH- pyrazole-4-carboxylic acid (1.08 g, 3.44 mmol), triethylamine (1.44 mL, 10.3 mmol) and PyBOP (2.68 g, 5.15 mmol). Stir at ambient temperature for 3 h. Concentrate the reaction mixture and purify the residue by flash silica gel chromatography using a gradient of 0-100% (5: 1 EtOAc: 2 M NuEta3/MeOEta) in hexanes. Dissolve the isolated product in CH2Cl2 (10 mL) and add 2 M HCl in Et2O (8 mL). Remove solvents under a stream of N2 and dry in a vacuum oven at 50 0C overnight to afford the title compound (612 mg, 32%). ES/MS (m/z) 491.2 (M+l). Prepare the amides in the table below by essentially following the procedure described in Example 34, using the appropriate carboxylic acid. Purify Example 36 over an SCX column (eluting with 2 M NH3/MeOH) followed by flash chromatography.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.