Introduction of a new synthetic route about 3-Nitro-1H-pyrazole-1-ethanol

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Nitro-1H-pyrazole-1-ethanol, and friends who are interested can also refer to it.

Reference of 956951-01-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 956951-01-2 name is 3-Nitro-1H-pyrazole-1-ethanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution 2-(3-nitro-pyrazol-1-yl)-ethanol (3.46 g, 22.02 mmol) in ethanol (40 mL) was placed in a Parr shaker bottle and treated with 10% palladium on carbon (350 mg). The bottle was then put on the Parr shaker and charged with hydrogen to 50 psi and let shake for 1 h. After this time, the reaction mixture was filtered through celite and the celite washed with ethanol. The filtrate was then concentrated in vacuo and azeotroped with acetonitrile and then chloroform to afford 2-(3-amino-pyrazol-1-yl)-ethanol (3.02 g, >quant.) as a light yellow viscous oil: 1H NMR (300 MHz, DMSO-d6 delta ppm 7.26 (d, J=1.83 Hz, 1H), 5.34 (d, J=2.20 Hz, 1H), 4.76 (t, J=5.31 Hz, 1H), 4.50 (s, 2H), 3.78-3.88 (m, 2H), 3.62 (q, J=5.74 Hz, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Nitro-1H-pyrazole-1-ethanol, and friends who are interested can also refer to it.

Simple exploration of 3-Nitro-1H-pyrazole-1-ethanol

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 956951-01-2.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 956951-01-2, name is 3-Nitro-1H-pyrazole-1-ethanol, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3-Nitro-1H-pyrazole-1-ethanol

To a stirred solution of compound 95 (4.0 g, 25.477 mmol) in CH2C12 (50 mL) was added triethylamine (8.86 mL, 30.573 mmol) at 0 C and stirred. To this reaction mixture was added methanesulfonyl chloride (2.35 mL, 30.573 mmol) in CH2C12 (5 mL) dropwise over 10 min at 0 C and stirred at the room temperature for 2 h. The reaction was monitored by TLC for complete consumption of compound 95. The reaction mixture was quenched with water (50 mL) and extracted with EtOAc (50 mL x 2). The combined organic layer was washed with brine (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 96 (6 g, crude). 1H NMR (400 MHz, DMSO-d6) delta 3.15 (s, 3H), 4.61 (s, 4H), 7.09 (d, J=2.45 Hz, 1H), 8.09 (d, J=2.45 Hz, 1H). LCMS: 236 (M+H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 956951-01-2.

Some tips on 1-Methyl-1H-pyrazole-5-carboxylic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazole-5-carboxylic acid, and friends who are interested can also refer to it.

Electric Literature of 16034-46-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16034-46-1 name is 1-Methyl-1H-pyrazole-5-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 1-methyl-1H-pyrazole-5-carboxylic acid (compound 4A, 81 mg, 0.640 mmol), DIEA (286 mg, 2.22 mmol) in CH2Cl2 (10 mL) was added EDCI (189 mg, 0.985 mmol), DMAP (90 mg, 0.739 mmol) at -5 C., then the mixture was stirred at -5 C. for 30 min, (E)-2-methyl-4-(2-methylstyryl)aniline (compound 4, 110 mg, 0.493 mmol) was added, the mixture was stirred at -5 C. for 30 min, warmed to 25 C. and stirred for 11 hrs. TLC (petroleum ether:ethyl acetate=1:1, Rf=0.60) showed starting material consumed completely. The mixture was concentrated in vacuum to give yellow oil. The oil was purified by silica gel column chromatography (petroleum ether:ethyl acetate=100:0 to 60:40) to give (E)-1-methyl-N-(2-methyl-4-(2-methylstyryl)phenyl)-1H-pyrazole-5-carboxamide (compound I-5, 65 mg, 39% yield) as white solid. 1H NMR (400 MHz, DMSO-d6) delta ppm 9.86 (s, 1H), 7.66 (d, J=7.4 Hz, 1H), 7.52-7.58 (m, 2H), 7.49 (d, J=8.2 Hz, 1H), 7.32-7.44 (m, 2H), 7.16-7.23 (m, 3H), 7.05?7.14 (m, 2H), 4.09 (s, 3H), 2.42 (s, 3H), 2.27 (s, 3H); ES-LCMS m/z 332.3 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazole-5-carboxylic acid, and friends who are interested can also refer to it.

Share a compound : 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, its application will become more common.

Application of 345637-71-0,Some common heterocyclic compound, 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, molecular formula is C7H7F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 0.15M solution of (2-Aminopyndin-4-yl)(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5- yl)methanone (Preparation 24, 500 uL, 75 umol) in DMA was added to [5-methyl-3- (trifluoromethyl)-1 H-pyrazol-1 -yl]acetic acid (75 uM) followed by NMM (25 uL, 150 umol), DMAP (3.5 umol) and a 0.15M solution of HATU (500 uL, 75 umol) in DMA. The reaction was shaken at 50C for 16 hours. The reaction was concentrated in vacuo and purified using preparative HPLC (Purification method 2 below, initial gradient 25% A, final gradient 55% A) to obtain the title compound as the TFA salt. LCMS Rt = 2.85 minutes MS m/z 472 [M+H]+ The following compounds were prepared as described above for Example 147 using (2- aminopyridin-4-yl)(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone (Preparation 24) and the appropriate acid with purification using preparative HPLC using one of the two methods below (initial and final gradients for each compound are reported in the table). Purification Method 1 : Column: YMC-pack ODS-AQ 150 x 30mm, 5 um, mobile phase A: acetonitrile; Mobile phase B: 0.1 % TFA in water. Gradient time: 8 minutes. Flow rate: 35 mL/min. Initial/end gradients are reported for each compound below. Purification Method 2: Column: Sepax BR-C18 100 x 21 .2 mm, 5 um, mobile phase A: acetonitrile; Mobile phase B: 0.1 % TFA in water. Gradient time: 8 minutes. Flow rate 30 mL/min. Initial/end gradients are reported for each compound below

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, its application will become more common.

Simple exploration of Methyl 5-methyl-1H-pyrazole-3-carboxylate

Statistics shows that Methyl 5-methyl-1H-pyrazole-3-carboxylate is playing an increasingly important role. we look forward to future research findings about 25016-17-5.

Application of 25016-17-5, These common heterocyclic compound, 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 1.2 g of a mixture of acids 8 and 9 obtained in the previous synthesis 5 mL of acetic anhydride was added, the mixture was stirred for 4 hours at boiling and left overnight. The precipitated crystals in the form of fine colorless needles were filtered off and washed with acetic acid. Yield 452 mg (41%), mp 144-145C. The acetic anhydride contained in the mother liquor was hydrolyzed with water. The precipitated crystals were filtered off, washed with water and after drying recrystallized from methanol. Additionally, 101 mg of the reaction product were obtained, total yield 50%. IR spectrum, nu, cm-1: 1730(CO), 1630 (Ph). 1H NMR spectrum, delta, ppm: 2.41 s(3H, CH3), 6.97 s (1H, CH), 7.41 t (1H, Ph, J 7.2 Hz),7.45 t (2H, Ph, J 7.2 Hz), 7.82 d (2H, Ph, J 7.6 Hz),8.50 s (1H,CH). 13 NMR spectrum, delta, ppm: 15.3(CH3), 109.1 (CH), 109.5 (CH), 126.1 (Ph), 128.8,130.6 (Ph), 131.2 (Ph), 131.7 (Ph), 143.6, 152.9, 154.8(CO). Found, %: C 64.98; H 4.48; N 12.40.13H10N2O2. Calculated, %: C 65.02; H 4.46; N 12.38.

Statistics shows that Methyl 5-methyl-1H-pyrazole-3-carboxylate is playing an increasingly important role. we look forward to future research findings about 25016-17-5.

New learning discoveries about 3-Amino-5-phenylpyrazole

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1572-10-7, name is 3-Amino-5-phenylpyrazole, A new synthetic method of this compound is introduced below., Product Details of 1572-10-7

General procedure: The general method was described for the synthesis of D1. Compound C1 (150 mg, 0.393 mmol) was dissolved in ethanol (2 mL),followed by addition of 5-phenyl-1H-pyrazol-3-amine (62.63 mg, 0.393 mmol) and triethylamine (119.43 mg, 1.18 mmol). The mixture was stirred at room temperature for 5 h. The resultant mixture was purified by column chromatography to give D1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Share a compound : 5-Methyl-1H-pyrazol-3-amine

The synthetic route of 5-Methyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Application of 31230-17-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

The 2,4-dichloroquinazoline (1.00g, 5 . 0mmol) and 5-methyl -1H-pyrazol-3-amine (498 mg, 5 . 1mmol) dissolved in ethanol (20 ml) in, adding Et3N (1.07g, 10 . 6mmol). After adding, the reaction mixture stirring at room temperature overnight, after the reaction, the reaction mixture is concentrated under reduced pressure. Added to the resulting residue in the mixed solution of water and ethanol (10/1(v/v), 22 ml), stirring beating at room temperature 0.5 hours, filtering, the filter cake is washed with petroleum ether (20mLx3) washing, collecting filter cake to obtain the title compound as light brown solid (1.30g, 100percent)

The synthetic route of 5-Methyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Share a compound : 3-Nitro-1H-pyrazole

According to the analysis of related databases, 26621-44-3, the application of this compound in the production field has become more and more popular.

Electric Literature of 26621-44-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 26621-44-3 as follows.

A mixture of 3-nitro-1H-pyrazole (10.0 g, 88.43 mmol), 2,2-dimethyl-oxirane (15.7 mL, 176.9 mmol), potassium carbonate (18.2 g, 132 mmol) and DMF (100 mL) was stirred at 100 C. for 1 h, then stirred overnight at rt. The mixture was then diluted with ethyl acetate and water, the organic layer was separated, dried over Na2SO4, and filtered. The resulting mixture was concentrated under reduced pressure to yield the crude product that was purified (50% EtOAc/heptane) to yield the product 2-methyl-1-(3-nitro-pyrazol-1-yl)-propan-2-ol as a waxy solid (4.88 g, 30%).

According to the analysis of related databases, 26621-44-3, the application of this compound in the production field has become more and more popular.

The origin of a common compound about Diethyl 3,5-pyrazoledicarboxylate

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, A new synthetic method of this compound is introduced below., Computed Properties of C9H12N2O4

To a solution of diethyl 1H-pyrazole-3,5-dicarboxylate (0.25 g, 1.18 mmol) in acetone (10 ml) were added 2-bromo-1-(3-fluoro-4-methylphenyl)ethanone (0.33 g, 1.41 mmol) and potassium carbonate (0.41 g, 2.95 mmol). The mixture was stirred at RT over night. After filtering off the sol- ids, the filtrate was concentrated and the residue dried in vacuo to give 0.48 g (99% of theory, 87% purity) of the title compound. This compound was used without further purification. LC/MS [Method 3]: Rt = 2.07 min; MS (ESIpos): m/z = 363 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

The important role of (1H-Pyrazol-1-yl)methanol

The synthetic route of 1120-82-7 has been constantly updated, and we look forward to future research findings.

Application of 1120-82-7,Some common heterocyclic compound, 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, molecular formula is C4H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: L1 was prepared by a similar procedure as described in the literature[6,49,52-54]. The CH2Cl2 solution (10.0 mL) of para-phenylenediamine(1.08 g, 0.010 mol) was added a CH2Cl2 solution(50.0 mL) of 1H-1-pyrazolyl-1-methanol (3.92 g, 0.040 mol). Thereaction solution was dried over the MgSO4 after stirring the reactionmixture at room temperature for 3 days.

The synthetic route of 1120-82-7 has been constantly updated, and we look forward to future research findings.