Day: March 10, 2021

Related Products of 99465-09-5, The chemical industry reduces the impact on the environment during synthesis 99465-09-5, name is 5-Bromoquinolin-2(1H)-one, I believe this compound will play a more active role in future production and life.

delta: 1.50-1.65(2H, m), 1.75-1.95(2H, m), 2.39-2.45(2H, m), 2.65-2.85(4H, m), 3.00-3.20(2H, m), 3.50-3.70(1H, m), 7.07(2H, s), 10.05(1H, s) mp 209-212 C. The above 5-bromocarbostyril was dissolved in 1 ml of hydrogen chloride-methanol solution, and mixture was refluxed for 1 hr. The reaction mixture was concentrated and purified by a silica gel column chromatography to give 24 mg of 5-bromo-6-(4-hydroxypiperidino)-3,4-dihydrocarbostyril.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromoquinolin-2(1H)-one, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 75090-52-7, name is 7-Bromo-4-chloroquinoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H5BrClN

17 A solution of 4-chloro-7-bromoquinoline 17-A (1 g, 4.1 mmol) (see Scheme 1 : general preparation of quinolines), hexamethyidistannane 17-B (1.35 g, 4.1 mmol) and [(C6H5)P]4Pd (237 mg) in 1,4-dioxane (10 ml) was heated to 105-110 C for 2 hours. The solution was cooled to room temperature. Column chromatography (hexane/EtOAc 5: 1) gave 4-chloro-7- (trimethylstannyl) quinoline 17-C (1.26 g, 94%).

The synthetic route of 7-Bromo-4-chloroquinoline has been constantly updated, and we look forward to future research findings.

Related Products of 68236-20-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68236-20-4, name is 2-Chloro-7-methoxyquinoline-3-carbaldehyde belongs to quinolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step-c Synthesis of 7-methoxy-2-oxo-1,2-dihydroquinoline-3-carbaldehyde A suspension of 2-chloro-7-methoxyquinoline-3-carbaldehyde (8.0 g, 36.2 mmol) in 70% acetic acid (370 mL) was heated to 110 C. for 16 h. Upon cooling the reaction mixture to room temperature and poured into crushed ice;solid was filtered off and washed with water, dried under reduced pressure for overnight to give title compound as pale yellow solid (5.6 g, 76%). 1H NMR (400 MHz, DMSO-d6) delta 12.07 (s, 1H), 10.18 (s, 1H), 8.43 (s, 1H), 7.84 (d, J=8.9 Hz, 1H), 6.89 (dd, J=2.5 Hz, 8.8 Hz, 1H), 6.82 (d, J=1.9 Hz, 1H), 3.86 (s, 3H); LC-MS: m/z 204.1 (M+1)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-7-methoxyquinoline-3-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Some common heterocyclic compound, 68500-37-8, name is 4-Chloro-7-methoxyquinoline, molecular formula is C10H8ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C10H8ClNO

2-hydroxyacetic acid (5.00 g, 65 mmol) and KOH (6.00 g,90 mmol) were mixed and heated to 170 C. 4-chloro-7-methoxyquinoline (5.00 g, 26 mmol) dissolved in DMSO (20 mL)was added dropwise. The reaction mixture was stirred at 170 C for2.5 h. After cooled to room temperature, the solutionwas poured to50 mL ice water. Saturated aqueous sodium carbonate solutionwasadded to adjust the PH to 7-8. The mixture was filtered and driedin vacuo to give 3.70 g of 4 as brown solid: 62% yield. m.p.:223-225 C; HRMS (ESI+) m/z 234.0763 (234.0761 calcd forC12H12NO4+, [M+H]+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 68500-37-8, its application will become more common.

Related Products of 3033-82-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3033-82-7 as follows.

After adding 53.26 parts of cyclododecane to 7.00 parts of the compound represented by the formula (X-1)And heated to 180 C to dissolve them.After confirming the dissolution,13.88 parts of 8-chloroquinaldine was added and refluxed at 200 C for 9 hours. After completion of the reaction,The reaction solution was pouredTo 500 parts of acetonitrile and the precipitate was collected by filtration.The resulting precipitate was washed with 500 parts of ethanol,The use of dimethyl subunit 500Were each repulpered to give a yellow solid.The yellow solid under reduced pressure at 60 Followed by drying(Z-2).

According to the analysis of related databases, 3033-82-7, the application of this compound in the production field has become more and more popular.

Related Products of 68236-20-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68236-20-4 name is 2-Chloro-7-methoxyquinoline-3-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Anhydrous DMF (1 mL) and Et3N (0.56 mL, 4.00 mmol, 4equiv), previously degassed with bubbling argon for 10 min, were added to a flask containing the appropriate chlorinated quinoline(1.00 mmol, 1 equiv), [PdCl2(PPh3)2] (35.1 mg, 0.050 mmol, 0.05equiv), and CuI (9.5 mg, 0.050 mmol, 0.05 equiv) under an argon atmosphere.Finally, the appropriate alkyne derivative (1.20 mmol, 1.2equiv) was added dropwise to the mixture, which was then stirred over night at r.t. After completion of the reaction (attested by TLCanalysis), the mixture was filtered through a short pad of silica and Celite and eluted with EtOAc. The crude was concentrated under reduced pressure and purified by column chromatography (silica gel, various solvent mixtures).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-7-methoxyquinoline-3-carbaldehyde, and friends who are interested can also refer to it.

75457-13-5, name is 3-Methylquinolin-8-ol, belongs to quinolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C10H9NO

A) A solution of 3-methyl-8-hydroxyquinoline (15.9 g, 0.10 mole) is added to a mixture of 70% nitric acid (162 g, 1.8 mole) (18 molar equivalents) and Manganese dioxide (0.33 g, 0.0038 mole) (0.038 molar equivalents) at a temperature of 80-100 C. over a 1 hour period, with stirring. The resultant overhead gases are scrubbed and vented. The reaction mixture is heated at 100-105 C. for 4 hours, cooled to 85 C., treated with 88% formic acid at 85-95 C. over a 20 minute period, further heated at 85-95 C. for 0.5 hour, cooled to 0 C., stirred for 0.5 hour and filtered. The filtercake is washed with acetone to give 5-methyl-2,3-pyridinedicarboxylic acid, 13.6 g (78.3% yield), 98.8% purity by HPLC analysis.

The synthetic route of 75457-13-5 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 607-34-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 607-34-1 as follows.

General procedure: A solution of the appropriate amide (1 mmol) in anhydrous DMSO (4 ml) was treated at room temperature by adding a suspension of NaH in paraffin oil (40 mg, 1 mmol of NaH) and 5-nitroquinoline (1) (87 mg, 0.5 mmol). The mixture was vigorously stirred at room temperature for the duration indicated in Table 1. The reaction mixture was then poured onto ice (50 g) and after warming to room temperature was acidified with dilute HCl solution to pH ~7. The precipitate that formed was filtered off, washed with water, and dried. The obtained mixture was separated into fractions by the dry silica gel flash chromatography.

According to the analysis of related databases, 607-34-1, the application of this compound in the production field has become more and more popular.

Application of 139399-67-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 139399-67-0 name is 3-Bromoquinolin-8-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

8-Amino-3-bromoquinoline (4) (0.3 g, 1.3 mmol) was dissolved in 10 mL of 70% sulfuric acid and placed in a Q-Tube (Sigma Aldrich). The tube was sealed and heated with stirring at 22000 for 3 days. After cooling to ambient temperature, the reaction solution was brought to pH 8 by addition of NH4OH (16 M), followed by extraction with ethyl acetate (4 x 25 mL). The organic phases were combined, dried over Na2504, filtered, and evaporated todryness. The crude product was purified by column chromatography on silica gel (7 g) using3:1 dichloromethane/hexane as the eluent. Fractions containing the product were combinedand evaporated to dryness to give 5 as a white solid 0.184 g (34% yield, mp 99-101 00, litmp 111.5-1 12.5 00) 1H NMR (400 MHz, ODd3) O 8.77 (1H, d, J= 2.0 Hz), 8.32 (1H, d, J=2.0 Hz), 7.99 (1H, 5), 7.48 (1H, t, J= 8.0 Hz), 7.18 (1H, dd, J= 23.2 Hz, J= 9.6 Hz). LCMSfound 225.90, [M+2H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromoquinolin-8-amine, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1246549-62-1, name is 7-Bromo-3-chloroquinoline, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 7-Bromo-3-chloroquinoline

3-Chloro-7-bromo-quinoline (10 g, 41.2 mmol) was dissolved in dichloromethane (150 mL). Then m-CPBA (7.83 g, 45.3 mmol) was added in portions. The mixture was stirred at 35 C for 16 hours. The mixture was poured into a saturated Na2S03 aqueous solution. The mixture was extracted by CH2CI2. Then the mixture was washed by a saturated Na2S03 aqueous solution (50 mL x2) and a saturated NaHC03 aqueous solution (50 mL x2). The organic was dried over anhydrous Na2S04 and concentrated. The white solid was precipitated and filtered to give intermediate 180 (10 g, 78.8 % yield) as a yellow solid.

According to the analysis of related databases, 1246549-62-1, the application of this compound in the production field has become more and more popular.