Day: March 9, 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 70951-85-8, name is 4-Bromo-1-(tert-butyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

To a -78 0C solution of 4-bromo-l -7-butyI-lH-pyrazole (15 g, 74.3 mmol) in anhydrous THF (100 mL) was added /7-BuLi (2.5 M in hexane, 53 mL, 132 mmol) under N2, and the resulting mixture was stirred at -78¡ãC for 30 min. Excess dry ice was added at -78 0C, and the mixture was warmed slowly to RT and stirred overnight. The reaction was concentrated in vacuo, water was added and the pH was adjusted to pH 3 by the addition of 2N aq HCI. The aqueous solution was extracted with EtOAc. The extracts were washed with brine, dried (MgSO4) and concentrated in vacuo. The residue was recrystallized (EtO Ac-pet, ether) to give 1 -/-butyl- lH-pyrazole-4-carboxylic acid (8.0 g, 67 percent yield). 1H NMR (300 MHz, CDCl3): ^ 8.10 (s, 1 H), 8.03 (s, 1 H), 1.64 (s, 9 H); MS (ESI) m/z: 168.9 [M+Hf.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 70951-85-8.

Reference of 151521-49-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 151521-49-2 as follows.

A mixture of methyl 3-oxo-3-(3-pyridyl)propanoate (100 mg, 558.12 muiotaetaomicron, 1 eq) and 4-isopropyl- 1H-pyrazol-5-amine (69.86 mg, 558.12 muiotaetaomicron, 1 eq) in AcOH (2 mL) was stirred at 120C for 0.5 h. The reaction mixture was concentrated under reduced pressure to give the crude product 3- isopropyl-5-(3-pyridyl)pyrazolo[l,5-a]pyrimidin-7-ol (120 mg, 471.91 muiotaetaomicron, 84.6% yield, crude purity) as brown oil which was used in the next step without further purification. MR (400 MHz, OMSO-de) delta ppm 9.47-8.95 (m, 1H), 8.80-8.70 (m, 1H), 8.30-8.20 (m, 1H), 7.87, 7.38 (m, 1H), 7.60-7.50 (m, 1H), 7.08, 1.24 (d, J = 6.8 Hz, 3H), 1.07 (dd, J = 3.5, 6.8 Hz, 3H); ES-LCMS m/z 255.1 [M+H].

According to the analysis of related databases, 151521-49-2, the application of this compound in the production field has become more and more popular.

Application of 36650-74-5, A common heterocyclic compound, 36650-74-5, name is 1H-Pyrazole-3-carbonitrile, molecular formula is C4H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of SB-FF (100 mg, 0.241 mmol), lH-pyrazole-3-carbonitrile (45 mg, 0.48 mmol), K2CO3 (66 mg, 0.48 mmol) and DMF (3 mL) were stirred at room temperature for 2 h. TLC showed the reaction was finished. The reaction mixture was poured into brine (10 mL) and extracted with EtOAc (10 mLx2). Combined the organic layers and dried over Na2S04, concentrated to give crude product, which was purified by silica gel column to give SB-13 (30 mg, yield: 28%) as a white solid. 1H NMR: (400 MHz, CDC13) delta 7.48 (s, 1H), 6.73 (s, 1H), 4.79-4.97 (m, 2H), 4.47-4.65 (m, 1H), 2.56-2.63 (m, 1H), 2.30-2.20 (m, 1H), 2.10-2.00 (m, 1H), 1.90-1.60 (m, 6H), 1.50-1.20 (m, 15H), 0.85-0.75 (m, 1H), 0.70 (s, 3H). LCMS: rt = 1.23 mm, m/z = 428.2 [M+H]+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 35344-95-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35344-95-7 name is 1H-Pyrazole-4-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solution of 2,3-diamino-1,4-naphthoquinone (1.0 mmol),appropriate aromatic aldehyde (1.0 mmol) with sodium pyrosulfitein DMF was stirred at 120 C overnight. On completion of the reactionmonitored by TLC, the solvent was evaporated and the residuewas purified by silica gel chromatography by DCM/MeOHsystem to afford the final product. If necessary, the crude productcould be recrystallized in methanol or DMSO to afford pure sample.4.1.5.1. 2-(2-Chlorophenyl)-1H-naphtho[2,3-d]imidazole-4,9-dione(T1). Pale yellow solid; yield 80percent;

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazole-4-carbaldehyde, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 133228-21-4, Safety of N,N-Dimethyl-1H-pyrazole-1-sulfonamide

Step 2: Preparation of 3-bromo-pyrazole-l-sulfonic acid dimethylamide; Pyrazole-1-sulfone acid dimethylamide (17.6 g) was dissolved in dry THF (200 mL) and cooled to -78C. A solution of n-butyllithium (80 mL, 1.3 M) was added slowly over a period of 15 min and stirred for further 15 min at – 78C. A solution of 1, 2-dibromo-l, 1, 2 , 2-tetrachloroethane(35.8 g) in dry THF (60 mL) was added within 10 min to this solution and stirred for further 15 min at -78C, then the cool bath was removed and the mixture was quenched with water after stirring for 1 h. The reaction mixture was extracted 3x with ethyl acetate, the combined org. layers were washed with brine, dried over MgSO4 and concentrated in vacuum.The residue was purified by column chromatography (silica gel 60, hexane/ethyl acetate = 5:1, Rf = 0.25) to afford 21.3 g of the title compound of the formulae2 as a colorless oil.1H-NMR (CDCl3, TMS) delta (ppm) : 3.08 (6H, s) , 6.43 (IH, m) , 7.61 IH, m) .

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference of 1008-79-3, The chemical industry reduces the impact on the environment during synthesis 1008-79-3, name is 1-Phenyl-1H-pyrazol-3(2H)-one, I believe this compound will play a more active role in future production and life.

A solution of 3-hydroxy-1-methyl-1H-pyrazole (1) [ 38 ] (710mg, 7.2mmol) in dry DMF (20mL) was cooled to 0C under inert atmosphere and NaH (60% dispersion in mineral oil, 290mg, 7.2mmol) was added portion wise. After stirring mixture for 15min benzyl chloride (0.82mL, 7.2mmol) was added drop wise. The mixture was stirred at 60C for 1h, then poured into water and extracted with ethyl acetate. The organic layers were combined, washed with brine, dried over Na2SO4, filtrated, and the solvent was evaporated. The residue was purified by column chromatography (SiO2, eluent: ethyl acetate/n-hexane, 1:7, v/v) to give pure 3 as a brown liquid. Yield 90%, 1205mg.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Phenyl-1H-pyrazol-3(2H)-one, other downstream synthetic routes, hurry up and to see.

Related Products of 16034-46-1,Some common heterocyclic compound, 16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

DIPEA (370 )lL, 2.24 mmol) was added to a stirred solution of glycine methyl20 ester hydrochloride (70 mg, 0.56 mmol), 1-methyl-1H-pyrazole-5-carboxylic acid (71 mg,0.57 mmol) and HATU (255 mg, 0.67 mmol) in anhydrous DMF (1 mL) under a nitrogenatmosphere. The mixture was stirred at 20C for 15 h, then quenched by the addition ofsaturated aqueous sodium hydrogen carbonate solution (7 mL) and water (7 mL). Thematerial was extracted sequentially with ethyl acetate (3 x 7 mL) and 1:1 isopropanol/25 chloroform (2 x 7 mL). The combined organic layers were washed with brine (2 x 7 mL)and dried over sodium sulfate, then filtered and concentrated in vacuo. The residue waspurified by flash column chromatography, using a gradient of ethyl acetate in heptane (0-100%), to afford the title compound (110 mg, quantitative) as an orange-brown oil. DH(250 MHz, DMSO-d6) 8.92 (t,J5.6 Hz, 1H), 7.48 (d,J2.1 Hz, 1H), 6.89 (d,J2.1 Hz,30 1H), 4.04 (s, 3H), 3.98 (d, J 5.9 Hz, 2H), 3.66 (s, 3H). HPLC-MS (method 6): MH+ m/z198, RT 0.52 minutes.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazole-5-carboxylic acid, its application will become more common.

Reference of 57999-06-1,Some common heterocyclic compound, 57999-06-1, name is 4-Phenyl-1H-pyrazol-5-amine, molecular formula is C9H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A suspension of 3(5)-amino-4-(thien-2-yl)pyrazole (1h) or 3(5)-amino-4-phenylpyrazole (1i) 11,13 (10 mmoles) and ethyl 2-(pyrazol-10-yl)-2-formylacetate (A) or ethyl 2-(imidazol-10-yl)-2-formylacetate (B) (10 mmoles) in dyglime (20 mL) was refluxed under magnetic stirring until the starting material disappeared. The precipitate was collected by filtration from the reaction mixture and recrystallized by suitable solvent, obtaining compounds 5a, 5b, 6a and 6b respectively.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Phenyl-1H-pyrazol-5-amine, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 83-10-3, name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

To a solution of 4-((7-methoxyquinolin-4-yl)oxy)aniline (4 g, 15 mmol) and l,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-lH-pyrazole-4-carboxylic acid (3.56 g, 18 mmol) in CH2C12 (42 mL) was added HOAT (0.41 g, 3 mmol) at 43 C. The reaction was stirred at 43 C overnight, then cooled to rt and diluted with CH2CI2 (42 mL). The organic phase was separated, washed with water (42 mL x 2), dried over Na2S04 and concentrated in vacuo. The residue was stirred in EtOH aqueous solution (20 mL of EtOH in 20 mL of water) at rt for 3 h and collected through filtration to afford the title compound as a light yellow solid (5.6 g, 77.6%). MS (ESI, pos, ion) m/z: 481.0 [M+H]+; NMR (400 MHz, CDC13): delta 2.80 (s, 3H), 3.36 (s, 3H), 3.96 (s, 3H), 6.45 (d, J= 5.3 Hz, 1H), 7.11-7.13 (m, 2H), 7.20 (dd, J= 2.5 Hz, 9.2 Hz, 1H), 7.35 (t, J= 1.1 Hz, 2.2 Hz, 1H), 7.38 (d, J= 1.4 Hz, 1H), 7.41 (d, J= 2.5 Hz, 1H), 7.46-7.49 (m, 1H), 7.55 (t, J= 7.3 Hz, 15.2 Hz, 2H), 7.75 (dd, J= 2.1 Hz, 6.8 Hz, 2H), 8.24 (d, J = 9.2 Hz, 1H), 8.57 (d, J= 5.3 Hz, 1H), 10.77 (s, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 37687-24-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

N-iodosuccinimide (0.6 g, 2.59 mmol) was added to a solution of diethyl 3,5- pyrazoledicarboxylate (0.5 g, 2.35 mmol) in CHCI3 (10 mL) and the mixture was stirred at 80 C for 24 hours. Then more of N-iodosuccinimide (0.6 g, 2.59 mmol) was added and the mixture was stirred at 100 C for 48 hours more. Then the mixture was stirred at room temperature for 5 days. Then the mixture was treated with a saturated solution of Na2S203 and extracted with DCM. The organic layer was separated, dried (MgS04), filtered and the solvents evaporated in vacuo. The crude product was purified by flash columnchromatography (silica; MeOH in DCM 0/100 to 10/90). The desired fractions were collected and the solvents evaporated in vacuo to yield 4-iodo-lH-pyrazole-3,5-dicarboxylic acid diethyl ester (0.83 g, 90% yield).

The synthetic route of Diethyl 3,5-pyrazoledicarboxylate has been constantly updated, and we look forward to future research findings.